Savita Dhanvantari
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View article: Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD mdx:utrn−/− Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function
Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD mdx:utrn−/− Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function Open
Dilated cardiomyopathy affects greater than 1 in 2500 patients worldwide, including those with the neuromuscular disorder Duchenne muscular dystrophy (DMD). While inflammation within skeletal muscle is strongly associated with DMD patholog…
View article: Visions by WIMIN: Global Mentorship to Retain Underrepresented Trainees
Visions by WIMIN: Global Mentorship to Retain Underrepresented Trainees Open
View article: Misrouting of glucagon and stathmin-2 towards lysosomal system of α-cells in glucagon hypersecretion of diabetes
Misrouting of glucagon and stathmin-2 towards lysosomal system of α-cells in glucagon hypersecretion of diabetes Open
Glucagon hypersecretion from the pancreatic α-cell is a characteristic sign of diabetes, which exacerbates fasting hyperglycemia. Thus, targeting glucagon secretion from α-cells may be a promising approach for combating hyperglucagonemia. …
View article: Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia
Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia Open
Patients with diabetes mellitus exhibit hyperglucagonemia, or excess glucagon secretion, which may be the underlying cause of the hyperglycemia of diabetes. Defective alpha cell secretory responses to glucose and paracrine effectors in bot…
View article: Misrouting of Glucagon and Stathmin-2 Towards Lysosomal System of α-Cells in Glucagon Hypersecretion of Diabetes
Misrouting of Glucagon and Stathmin-2 Towards Lysosomal System of α-Cells in Glucagon Hypersecretion of Diabetes Open
Glucagon hypersecretion from the pancreatic α-cell is a characteristic sign of diabetes, which exacerbates fasting hyperglycemia. Thus, targeting glucagon secretion from α-cells may be a promising approach for combating hyperglucagonemia. …
View article: Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action
Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action Open
View article: Cardiovascular Physicians, Scientists, and Trainees Balancing Work and Caregiving Responsibilities in the COVID-19 Era: Sex and Race-Based Inequities
Cardiovascular Physicians, Scientists, and Trainees Balancing Work and Caregiving Responsibilities in the COVID-19 Era: Sex and Race-Based Inequities Open
View article: Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease
Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease Open
View article: Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease
Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease Open
The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility. These properties have made t…
View article: Sex, Gender, and Equity in Cardiovascular Medicine, Surgery, and Science in Canada: Challenges, Successes, and Opportunities for Change
Sex, Gender, and Equity in Cardiovascular Medicine, Surgery, and Science in Canada: Challenges, Successes, and Opportunities for Change Open
Although women face challenges and remain underrepresented in CV medicine, surgery, and science, this study highlights potential opportunities for improving access of female medical, surgical, and research trainees and professionals to spe…
View article: Stathmin-2 Mediates Glucagon Secretion From Pancreatic α-Cells
Stathmin-2 Mediates Glucagon Secretion From Pancreatic α-Cells Open
Inhibition of glucagon hypersecretion from pancreatic α-cells is an appealing strategy for the treatment of diabetes. Our hypothesis is that proteins that associate with glucagon within alpha cell secretory granules will regulate glucagon …
View article: Stathmin-2 Mediates Glucagon Secretion from Pancreatic α-Cells
Stathmin-2 Mediates Glucagon Secretion from Pancreatic α-Cells Open
Inhibition of glucagon hypersecretion from pancreatic α-cells is an appealing strategy for the treatment of diabetes. Our hypothesis is that proteins that associate with glucagon within alpha cell secretory granules will regulate glucagon …
View article: Front Cover: Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a (ChemMedChem 20/2019)
Front Cover: Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a (ChemMedChem 20/2019) Open
The Front Cover depicts the unique interaction between a tyrosine residue of our peptidomimetic and Arg283 in the binding pocket of the ghrelin receptor. This interaction is the rationale for the subnanomolar binding affinity of our ghreli…
View article: An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers Open
View article: Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation
Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation Open
Currently, the early preclinical detection of left ventricular dysfunction is difficult because biomarkers are not specific for the cardiomyopathic process. The underlying molecular mechanisms leading to heart failure remain elusive, highl…
View article: Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells Open
Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenviron…
View article: THE GROWTH HORMONE SECRETAGOGUE RECEPTOR, GHRELIN AND BIOCHEMICAL SIGNALING MOLECULES IN HUMAN HEART DISEASE
THE GROWTH HORMONE SECRETAGOGUE RECEPTOR, GHRELIN AND BIOCHEMICAL SIGNALING MOLECULES IN HUMAN HEART DISEASE Open
View article: Plasticity in the glucagon interactome reveals novel proteins that regulate glucagon secretion in αTC1-6 cells
Plasticity in the glucagon interactome reveals novel proteins that regulate glucagon secretion in αTC1-6 cells Open
Glucagon is stored within secretory granules of pancreatic alpha cells until a stimulus, such as a change in microenvironmental conditions, triggers its release. We hypothesized that the secretory response of the alpha cell to various stim…
View article: Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation
Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation Open
Background Currently, the early pre-clinical detection of left ventricular (LV) dysfunction is difficult as biomarkers are not specific for the cardiomyopathic process. The underlying molecular mechanisms leading to heart failure remain el…
View article: Development and Characterization of an <sup>18</sup>F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor
Development and Characterization of an <sup>18</sup>F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor Open
One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular …
View article: Development of a [<sup>68</sup>Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a)
Development of a [<sup>68</sup>Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a) Open
A 68Ga-labelled ghrelin(1-19) analogue is described as a high affinity peptide for ghrelin receptor PET imaging using a sequence derived directly from the endogenous ligand, yet modified for improved stability.
View article: Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice
Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice Open
Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are present in cardiac tissue. Activation of GHSR1a by ghrelin promotes cardiomyocyte contractility and survival, and changes in myocardial GHSR1a and circulat…
View article: EXPRESSION OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR AND GHRELIN IN HUMAN HEART FAILURE
EXPRESSION OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR AND GHRELIN IN HUMAN HEART FAILURE Open
View article: Secretory Granules Tell (Almost) All in Enteroendocrine Cells
Secretory Granules Tell (Almost) All in Enteroendocrine Cells Open
View article: Characterization of 5-(2-18F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas
Characterization of 5-(2-18F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas Open
Purpose: In diabetes, pancreatic beta cell mass declines significantly prior to onset of fasting hyperglycemia. This decline may be due to endoplasmic reticulum (ER) stress, and the system L amino acid transporter LAT1 may be a biomarker o…
View article: Characterization of 5-(2-18F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas
Characterization of 5-(2-18F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas Open
Purpose: In diabetes, pancreatic beta cell mass declines significantly prior to onset of fasting hyperglycemia. This decline may be due to endoplasmic reticulum (ER) stress, and the system L amino acid transporter LAT1 may be a biomarker o…
View article: Beta cell mass and 18F-L-FEHTP uptake
Beta cell mass and 18F-L-FEHTP uptake Open
View article: Time-activity values for 18F-L-FEHTP uptake in the pancreas and kidney of wt and Akita mice
Time-activity values for 18F-L-FEHTP uptake in the pancreas and kidney of wt and Akita mice Open
View article: Uptake of 18F-L-FEHTP in wt and Akita mice
Uptake of 18F-L-FEHTP in wt and Akita mice Open
View article: Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging
Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging Open
A fluorescein-GLP-1 (7-37) analog was generated to determine GLP-1R distribution in various cell types of the pancreas in both strains of mice and receptor-specific uptake was confirmed by blocking with exendin-4. Biodistribution studies w…