Sawsan Abuhamdah
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View article: Assessments of Wnt/JAK-STAT Signaling Pathway in Relation to Sfrp5 Among Patients with Cardiac Diseases
Assessments of Wnt/JAK-STAT Signaling Pathway in Relation to Sfrp5 Among Patients with Cardiac Diseases Open
Cardiovascular diseases have become a leading global health burden, with rising mortality worldwide. WNT and JAK/STAT have been highlighted as emerging biomarkers in cardiovascular disease pathogenesis. This study assessed the Wnt/JAK-STAT…
View article: Profile of GAS6 gene single nucleotide polymorphisms [GAS6 c.834+7G>A (rs8191974), and GAS6 c.1332C>T (rs1803628)] among a cohort of Egyptian women with preeclampsia: Relation to disease risk and severity
Profile of GAS6 gene single nucleotide polymorphisms [GAS6 c.834+7G>A (rs8191974), and GAS6 c.1332C>T (rs1803628)] among a cohort of Egyptian women with preeclampsia: Relation to disease risk and severity Open
This study represents the investigation of the potential link between single nucleotide polymorphisms (SNPs) in the growth arrest-specific 6 (GAS6) gene and preeclampsia (PE) in Egyptian women. Few existing research have explored this asso…
View article: Clinical, biochemical, and genetic study of TACE/TNF-α/ACE signaling pathway in pediatric COVID-19 infection
Clinical, biochemical, and genetic study of TACE/TNF-α/ACE signaling pathway in pediatric COVID-19 infection Open
Background: Pediatric patients infected with coronavirus disease 2019 (COVID-19) have unique clinical characteristics. Tumor necrosis factor (TNF) is a proinflammatory cytokine that greatly contributes to tumor pathogenesis.Purpose: To des…
View article: Self-medication practice among the general public in Jordan: a cross-sectional study
Self-medication practice among the general public in Jordan: a cross-sectional study Open
Objectives The phenomenon of self-medication is a noteworthy public health concern that is increasingly prevalent on a global level, particularly in developing nations. This study aims to explore the prevalence of self-medication of over-t…
View article: Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models
Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models Open
MO contains biologically active compounds with potential anti-nociceptive properties that modulate KATP, opioidergic and serotonergic pathways. These support the development of bioactive compounds from MO as anti-nociceptive agents.
View article: Alkaloids from <i>Peganum harmala</i> attenuated contractile responses of vascular smooth muscle cells
Alkaloids from <i>Peganum harmala</i> attenuated contractile responses of vascular smooth muscle cells Open
Purpose: To investigate the contractile responses of vascular smooth muscle cells (VSMCs) to spasmogens after incubation with harmaline, harmine, and harmalol, which are alkaloids obtained from Peganum harmala L., a member of the Zygophyll…
View article: Hospitalisations related to nervous-system diseases in Australia, 1998–2019: a secular trend analysis
Hospitalisations related to nervous-system diseases in Australia, 1998–2019: a secular trend analysis Open
Objective The burden of neurological disease-related disabilities and deaths is one of the most serious issues globally. We aimed to examine the hospitalisation profile related to nervous system diseases in Australia for the duration betwe…
View article: Knowledge of and Attitude towards Epilepsy among the Jordanian Community
Knowledge of and Attitude towards Epilepsy among the Jordanian Community Open
Background: Epilepsy is a disorder characterized by recurring seizures that do not have an immediate identifiable cause. It is a disorder with complex symptoms and a wide range of risk factors, with age, genetics, and origin being the most…
View article: Expression Patterns of Macrophage Migration Inhibitory Factor and Its Gene Variants (MIF-173 G˃C) in Verruca Vulgaris
Expression Patterns of Macrophage Migration Inhibitory Factor and Its Gene Variants (MIF-173 G˃C) in Verruca Vulgaris Open
MIF and its genetic variants are thought to play a pathogenic role in verruca vulgaris development and recurrence.
View article: Expression Patterns of Macrophage Migration Inhibitory Factor and Its Gene Variants (MIF-173 G&#x02C3;C) in Verruca Vulgaris
Expression Patterns of Macrophage Migration Inhibitory Factor and Its Gene Variants (MIF-173 G˃C) in Verruca Vulgaris Open
Mohammed H Hassan,1 Sawsan Abuhamdah,2,3 Bakheet EM Elsadek,4 Ashraf Abdelwahab,5 Tarek Hamdy Abd-Elhamid,6 Hanan M Fayed,7 Amany Abbass,8 Ahmed Alamir Mahmoud Abdallah,9 Marwa Mohamed,5 Wafaa Mohamed Abd-Elmagid5 1Department of Medical Bi…
View article: Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes
Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes Open
Initial serum UCHL1 assay could be a helpful marker in reflecting the degree of TSCI and predicting its outcome, though NGB needs further assessment.
View article: The Prevalence of Mental Distress and Social Support among University Students in Jordan: A Cross-Sectional Study
The Prevalence of Mental Distress and Social Support among University Students in Jordan: A Cross-Sectional Study Open
Objectives: To examine the prevalence of mental distress among university students in Jordan. Methods: An online cross-sectional study using a self-administered questionnaire was conducted between 12th of June and the 4th of August 2021 in…
View article: New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)
New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm) Open
Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the in vitro and in vivo models of epilepsy to probe the anticonvulsant potentia…
View article: Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy
Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy Open
Mutation of both GPHN (rs928553) and CYP2C9 (rs1278237) genes may be implicated as a genetic mediators of resistance in patients with PRE.
View article: Assessment of Therapeutic Effects of Platelet-Rich Plasma in Knee Osteoarthritis: Possible Role of Inflammatory Cytokines
Assessment of Therapeutic Effects of Platelet-Rich Plasma in Knee Osteoarthritis: Possible Role of Inflammatory Cytokines Open
Osteoarthritis (OA) is a multifactorial disease that commonly affects the knee. Tumor Necrosis Factor-α (TNF-α) regulates inflammation during OA. Macrophage Migration Inhibitory Factor (MIF) may be involved in the pathophysiolo…
View article: Paving Luteolin Therapeutic Potentialities and Agro‐Food‐Pharma Applications: Emphasis on <i>In Vivo</i> Pharmacological Effects and Bioavailability Traits
Paving Luteolin Therapeutic Potentialities and Agro‐Food‐Pharma Applications: Emphasis on <i>In Vivo</i> Pharmacological Effects and Bioavailability Traits Open
Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their bio…
View article: Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis
Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis Open
Survivin is an inhibitor of apoptosis as well as a promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein that displays potential for tumor suppression or propagation. The present study aimed to validate the expression levels o…
View article: Assessments of Therapeutic Effects of Platelet-rich Plasma in Knee Osteoarthritis: Possible Role of Inflammatory Cytokines
Assessments of Therapeutic Effects of Platelet-rich Plasma in Knee Osteoarthritis: Possible Role of Inflammatory Cytokines Open
Background: Osteoarthritis (OA) is a multifactorial disease that commonly affects the knee. Tumor necrosis factor-α (TNF-α) is able to regulate inflammation in OA. Macrophage migration inhibitory factor (MIF) may be involved in the pathoph…
View article: Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis
Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis Open
Background: Survivin is a common member of the inhibitors of the apoptosis protein (IAP) family and promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein with a potential for tumor suppression or propagation. The aim of this s…
View article: Effects of Beta-Carboline Alkaloids of Peganum Harmala on Induced Rat Ileum Contractions
Effects of Beta-Carboline Alkaloids of Peganum Harmala on Induced Rat Ileum Contractions Open
Peganum harmala L., Zygophyllaceae popularly known as Wild Syrian rue, a well-known plant in folk medicine for many pharmacological uses including antispasmodic activity. Chemical composition of the plant showed that the most important con…
View article: Herbal medicines: a cross-sectional study to evaluate the prevalence and predictors of use among Jordanian adults
Herbal medicines: a cross-sectional study to evaluate the prevalence and predictors of use among Jordanian adults Open
Introduction Understanding why adults resort to herbal medicine can help in planning interventions aimed at increasing awareness regarding herbal use. This study sought to investigate the prevalence and to determine factors for predicting …
View article: Abstracts from the 1st JoPPP Conference on Pharmaceutical Policy and Practice
Abstracts from the 1st JoPPP Conference on Pharmaceutical Policy and Practice Open
Pharmaceutical industry is one of the main contributors of public health.In a pharmaceutical industry, Data integrity is one of the most important aspect that relates to drug quality, safety, efficacy and purity.Recently, many industries h…
View article: Phenylketonuria in Sohag: A Preliminary Study
Phenylketonuria in Sohag: A Preliminary Study Open
Phenylketonuria (PKU) is one of the commonest inborn error of metabolism, it is an autosomal recessive metabolic genetic disorder characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it …
View article: Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening Open
Butyrylcholinesterase (BChE) plays an important role in the progression of the Alzheimer's disease. In this study, we used a structure-based virtual screening (VS) approach to discover new BChE inhibitors. A ligand database was filtered an…
View article: Spasmolytic and Antimicrobial Activities of Crude Extract of Bongardia chrysogonum L. Tubers
Spasmolytic and Antimicrobial Activities of Crude Extract of Bongardia chrysogonum L. Tubers Open
Background and Objective: Although Bongardia chrysogonum L. (family Berberidaceae) has been used in many countries in traditional medicine to treat gastrointestinal tract disorders, scientific evidence for this treatment is lacking. The pr…
View article: Anti-convulsant Effects of Bongardia chrysogonum L. Tuber in the Pentylenetetrazole-induced Seizure Model
Anti-convulsant Effects of Bongardia chrysogonum L. Tuber in the Pentylenetetrazole-induced Seizure Model Open
Background and Objective: The dried tuber of Bongardia chrysogonum (L.) is a popular folk remedy for its use in the treatment of epilepsy in traditional medicine. The study aimed to evaluate the anti-oxidant and anti-convulsant activity of…
View article: Behavioral and Neurochemical Alterations Induced by Vanillin in a Mouse Model of Alzheimer’s Disease
Behavioral and Neurochemical Alterations Induced by Vanillin in a Mouse Model of Alzheimer’s Disease Open
Background and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease where symptoms appear after significant neuronal loss.Current treatments for AD do not significantly alter the disease process, where they tempor…