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View article: SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics
SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics Open
Spatial transcriptomics enables multiplex profiling of gene cellular expression and location within the tissue context. Although large volumes of spatial transcriptomics data have been generated, the lack of systematic curation and analysi…
View article: DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls
DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls Open
DNA methylation profiles differ profoundly at two points: tumor to case-benign and case-benign to HDB, with clear distinction between ER + and ER- tumors. Case-benign tissues are not epigenetically "normal", are similar across both breasts…
View article: A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells Open
Lipid metabolism and the serine, one-carbon, glycine (SOG) and methionine pathways are independently and significantly correlated with estrogen receptor–negative breast cancer (ERneg BC). Here, we propose a link between lipid metabolism an…
View article: Neoadjuvant chemotherapy response and genetic susceptibility in recently parous women with breast cancer
Neoadjuvant chemotherapy response and genetic susceptibility in recently parous women with breast cancer Open
Introduction Women with recent parity are at increased short-term breast cancer (BC) risk and face a worse prognosis. The effect of parity on response to neoadjuvant chemotherapy (NAC) is unstudied, and the influence of inherited susceptib…
View article: SOAR elucidates disease mechanisms and empowers drug discovery through spatial transcriptomics
SOAR elucidates disease mechanisms and empowers drug discovery through spatial transcriptomics Open
Spatial transcriptomics provides researchers with a better understanding of gene expression within the tissue context. Although large volumes of spatial transcriptomics data have been generated, the lack of systematic curation and analysis…
View article: Multimodal Machine Learning in Precision Health
Multimodal Machine Learning in Precision Health Open
As machine learning and artificial intelligence are more frequently being leveraged to tackle problems in the health sector, there has been increased interest in utilizing them in clinical decision-support. This has historically been the c…
View article: Machine Learning Prediction of Parkinson’s Disease Onset and Subtype Using Germline Variants
Machine Learning Prediction of Parkinson’s Disease Onset and Subtype Using Germline Variants Open
A bstract Parkinson’s Disease is the second most common neurodegenerative disorder in the United States, and is characterized by a largely irreversible worsening of motor and non-motor symptoms as the disease progresses. A prominent charac…