Sayeeda Huq
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View article: P-2145. <i>Candida blankii</i>: An Emerging Threat among Hospitalized Neonates of Bangladesh
P-2145. <i>Candida blankii</i>: An Emerging Threat among Hospitalized Neonates of Bangladesh Open
Background Invasive fungal infections (IFIs) cause serious complications and fatality. Despite the severity of such magnitude, the true burden of these infections remains unclear. In LMICs like Bangladesh, there is a lack of surveillance m…
View article: Candida Blankii: An Emerging Fungal Threat Among Neonates in Critical Care Unit of Bangladesh
Candida Blankii: An Emerging Fungal Threat Among Neonates in Critical Care Unit of Bangladesh Open
View article: Risk or associated factors of wasting among under-five children in Bangladesh: A systematic review.
Risk or associated factors of wasting among under-five children in Bangladesh: A systematic review. Open
The risk/associated factors of wasting among U-5 children in Bangladesh were found at various multilevel. Rarely caused by any one factor alone, wasting in U-5 children results from an interplay between pregnant-mother's health and nutriti…
View article: A cross-sectional study of associations between the 13C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy
A cross-sectional study of associations between the 13C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy Open
In children at risk of EE, there were no associations between the 13C-SBT, LR, or other EE biomarkers encompassing different pathophysiological domains of EE. This trial was registered at clinicaltrials.gov as NCT04109352.
View article: A microbiome-directed therapeutic food for children recovering from severe acute malnutrition
A microbiome-directed therapeutic food for children recovering from severe acute malnutrition Open
Globally, severe acute malnutrition (SAM), defined as a weight-for-length z -score more than three SDs below a reference mean (WLZ < −3), affects 14 million children under 5 years of age. Complete anthropometric recovery after standard, sh…
View article: A microbiome-directed therapeutic food for children recovering from severe acute malnutrition
A microbiome-directed therapeutic food for children recovering from severe acute malnutrition Open
Severe acute malnutrition (SAM), defined anthropometrically as a weight-for-length z-score more than 3 standard deviations below the mean (WLZ<-3), affects 19 million children under 5-years-old worldwide. Complete anthropometric recovery a…
View article: Long-Term Developmental Assessment of Children Recovered from Hypernatremia
Long-Term Developmental Assessment of Children Recovered from Hypernatremia Open
Purpose: Imbalances in sodium result in acute neurologic symptoms such as seizures and impaired mental status. Studies investigating the long-term consequences of hypernatremia on cognitive, motor, and language development in children are …
View article: Inpatient Morbidity and Mortality of Severely Underweight Children Was Comparable to That of Severely Wasted Children in Dhaka, Bangladesh
Inpatient Morbidity and Mortality of Severely Underweight Children Was Comparable to That of Severely Wasted Children in Dhaka, Bangladesh Open
Both wasting and undernutrition are responsible for multiple morbidities and increased mortality in younger children hospitalized for acute illnesses. The question of whether children who are suffering from severe underweight are as vulner…
View article: Evaluation of Protein Creatinine Ratio as A Marker for Proteinuria among Children Recovered From Hypernatremia: A Longitudinal Observational Study
Evaluation of Protein Creatinine Ratio as A Marker for Proteinuria among Children Recovered From Hypernatremia: A Longitudinal Observational Study Open
Background: Proteinuria is one of the many markers of kidney damage. An increased protein creatinine ratio (Pr/Cr ratio) is known to have both diagnostic and prognostic value in detecting renal damage. The previous observational study reve…
View article: Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries
Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries Open
View article: Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering
Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering Open
Background: Nearly 150 million children under-5 years of age were stunted in 2020. We aimed to develop a clinical prediction rule (CPR) to identify children likely to experience additional stunting following acute diarrhea, to enable targe…
View article: Author response: Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering
Author response: Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering Open
Article Figures and data Abstract Editor's evaluation Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: Nearly 150 million child…
View article: Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering (stunting) presenting for diarrheal care
Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering (stunting) presenting for diarrheal care Open
Background Nearly 150 million children under-5 years of age were stunted in 2020. We aimed to develop a clinical prediction rule (CPR) to identify children likely to experience additional stunting following acute diarrhea, to enable target…
View article: Invasive Fungal Infections in Under-Five Diarrheal Children: Experience from an Urban Diarrheal Disease Hospital
Invasive Fungal Infections in Under-Five Diarrheal Children: Experience from an Urban Diarrheal Disease Hospital Open
Invasive fungal infections (IFIs) are opportunistic, especially in immunocompromised and hospitalized patients. Children with IFIs are more vulnerable to a fatal outcome. For early diagnosis and treatment, knowledge of the spectrum and fre…
View article: Intravenous Amoxicillin Plus Intravenous Gentamicin for Children with Severe Pneumonia in Bangladesh: An Open-Label, Randomized, Non-Inferiority Controlled Trial
Intravenous Amoxicillin Plus Intravenous Gentamicin for Children with Severe Pneumonia in Bangladesh: An Open-Label, Randomized, Non-Inferiority Controlled Trial Open
The World Health Organization (WHO) recommends intravenous (IV) ampicillin and gentamicin as first-line therapy to treat severe pneumonia in children under five years of age. Ampicillin needs to be administered at a six-hourly interval, wh…
View article: A Microbiota-Directed Food Intervention for Undernourished Children
A Microbiota-Directed Food Intervention for Undernourished Children Open
These findings provide support for MDCF-2 as a dietary supplement for young children with moderate acute malnutrition and provide insight into mechanisms by which this targeted manipulation of microbiota components may be linked to growth.…
View article: Vitamin D supplementation among Bangladeshi children under-five years of age hospitalised for severe pneumonia: A randomised placebo controlled trial
Vitamin D supplementation among Bangladeshi children under-five years of age hospitalised for severe pneumonia: A randomised placebo controlled trial Open
Introduction Vitamin D is important for its immunomodulatory role and there is an independent association between vitamin D deficiency and pneumonia. We assessed the effect of vitamin D supplementation on the outcome in children hospitaliz…
View article: Optimisation, validation and field applicability of a 13C-sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: study protocol for a prospective study in Bangladesh, India, Kenya, Jamaica, Peru and Zambia
Optimisation, validation and field applicability of a 13C-sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: study protocol for a prospective study in Bangladesh, India, Kenya, Jamaica, Peru and Zambia Open
Introduction Environmental enteropathy (EE) is suspected to be a cause of growth faltering in children with sustained exposure to enteric pathogens, typically in resource-limited settings. A major hindrance to EE research is the lack of se…
View article: Injectable Amoxicillin Versus Injectable Ampicillin Plus Gentamicin in the Treatment of Severe Pneumonia in Children Aged 2 to 59 Months: Protocol for an Open-Label Randomized Controlled Trial
Injectable Amoxicillin Versus Injectable Ampicillin Plus Gentamicin in the Treatment of Severe Pneumonia in Children Aged 2 to 59 Months: Protocol for an Open-Label Randomized Controlled Trial Open
Background Pneumonia causes about 0.9 million deaths worldwide each year. The World Health Organization (WHO) guidelines for the standard management of severe pneumonia requires parenteral ampicillin every 6 hours and once-daily parenteral…
View article: Clinical Manifestations of Hyponatremia and Hypernatremia in Under-Five Diarrheal Children in a Diarrhea Hospital
Clinical Manifestations of Hyponatremia and Hypernatremia in Under-Five Diarrheal Children in a Diarrhea Hospital Open
OBJECTIVE: To study clinical manifestations and outcome of hyponatremia and hypernatremia in children with diarrhea. METHOD: We compared children aged 0-59 months hospitalized from 1 January to 31 December 2013 with hyponatremia (serum sod…
View article: Proof-of-concept study of the efficacy of a microbiota-directed complementary food formulation (MDCF) for treating moderate acute malnutrition
Proof-of-concept study of the efficacy of a microbiota-directed complementary food formulation (MDCF) for treating moderate acute malnutrition Open
Background Childhood undernutrition remains a significant global health challenge accounting for over half of all under 5 child mortality. Moderate acute malnutrition (MAM), which leads to wasting [weight-for-length z-scores (WLZ) between …
View article: Injectable Amoxicillin Versus Injectable Ampicillin Plus Gentamicin in the Treatment of Severe Pneumonia in Children Aged 2 to 59 Months: Protocol for an Open-Label Randomized Controlled Trial (Preprint)
Injectable Amoxicillin Versus Injectable Ampicillin Plus Gentamicin in the Treatment of Severe Pneumonia in Children Aged 2 to 59 Months: Protocol for an Open-Label Randomized Controlled Trial (Preprint) Open
BACKGROUND Pneumonia causes about 0.9 million deaths worldwide each year. The World Health Organization (WHO) guidelines for the standard management of severe pneumonia requires parenteral ampicillin every 6 hours and once-daily parentera…
View article: Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children Open
Malnutrition and dietary repair Childhood malnutrition is accompanied by growth stunting and immaturity of the gut microbiota. Even after therapeutic intervention with standard commercial complementary foods, children may fail to thrive. G…
View article: A sparse covarying unit that describes healthy and impaired human gut microbiota development
A sparse covarying unit that describes healthy and impaired human gut microbiota development Open
Malnutrition and dietary repair Childhood malnutrition is accompanied by growth stunting and immaturity of the gut microbiota. Even after therapeutic intervention with standard commercial complementary foods, children may fail to thrive. G…
View article: Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition
Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition Open
Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need to obtain…
View article: Cholera forecast for Dhaka, Bangladesh, with the 2015-2016 El Niño: Lessons learned
Cholera forecast for Dhaka, Bangladesh, with the 2015-2016 El Niño: Lessons learned Open
A substantial body of work supports a teleconnection between the El Ni\\~no\nSouthern Oscillation (ENSO) and cholera incidence in Bangladesh. In particular,\nhigh positive anomalies during the winter (Dec-Feb) in Sea Surface Temperatures\n…
View article: Oral application of <scp> <i>E</i> </scp> <i>scherichia coli</i> bacteriophage: safety tests in healthy and diarrheal children from <scp>B</scp> angladesh
Oral application of <span> <i>E</i> </span> <i>scherichia coli</i> bacteriophage: safety tests in healthy and diarrheal children from <span>B</span> angladesh Open
Summary A T4‐like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo‐controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit …
View article: Diarrhea-associated pneumococcal meningitis with complicating hydrocephalus in a child in a resource-limited setting
Diarrhea-associated pneumococcal meningitis with complicating hydrocephalus in a child in a resource-limited setting Open
Introduction: Streptococcus pneumonia is the most common and intimidating cause of childhood meningitis. Its delayed diagnosis may be associated with hyponatremia and hypernatremia with fatal outcome. Case presentation: A previously health…
View article: Clinical Manifestations of Hyponatremia and Hypernatremia in Under-Five Diarrheal Children in a Diarrhea Hospital
Clinical Manifestations of Hyponatremia and Hypernatremia in Under-Five Diarrheal Children in a Diarrhea Hospital Open
Early diagnosis and prompt management of hypo- and hypernatremia by identifying simple clinical predicting factors of these two conditions in diarrheal children <5 years of age is critically important to prevent deaths in such children, es…
View article: Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh
Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh Open