Sayoni Das
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View article: Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts
Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts Open
Background Endometriosis affects about 10% of women usually of reproductive age. It often has severe negative impacts on patients’ quality of life, but the average time to a definitive diagnosis remains 7-9 years, and there are few effecti…
View article: Understanding DUSHI-VISHA from Samhita in COVID Vaccinated People
Understanding DUSHI-VISHA from Samhita in COVID Vaccinated People Open
Covid 19 vaccine had played an important role in controlling the spread of COVID virus. But post effects of the COVID vaccine has become major public health issues World wide. The immediate and later effects of Covid 19 vaccine has shown m…
View article: Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries
Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries Open
These results demonstrate the reproducibility of long COVID disease signal found by combinatorial analysis, broadly validating the results of the original analysis. They provide compelling evidence for a much broader array of genetic assoc…
View article: Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries
Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries Open
Background Long COVID is a major public health burden causing a diverse array of debilitating symptoms in tens of millions of patients globally. In spite of this overwhelming disease prevalence, staggering cost, severe impact on patients’ …
View article: ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders
ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders Open
The mechanical environment is sensed through cell-matrix contacts with the cytoskeleton, but how signals transit the nuclear envelope to affect cell fate decisions remains unknown. Nuclear actin coordinates chromatin motility during differ…
View article: Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries
Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries Open
Background Long COVID is a major public health burden causing a diverse array of debilitating symptoms in tens of millions of patients globally. In spite of this overwhelming disease prevalence and staggering cost, its severe impact on pat…
View article: Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals
Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals Open
We present a novel method for routinely identifying disease resilience associations that offers powerful insights for the discovery of a new class of disease protective targets. We show how this can be used to identify mechanisms in the ba…
View article: Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals
Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals Open
We present a novel method for routinely identifying disease resilience associations that offers powerful insights for the discovery of a new class of disease protective targets. We show how this can be used to identify mechanisms in the ba…
View article: Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis
Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis Open
Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies ha…
View article: Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis
Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis Open
Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies ha…
View article: Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis
Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis Open
Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies ha…
View article: Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis
Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis Open
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease that lacks known pathogenesis, distinctive diagnostic criteria, and effective treatment options. Understanding the genetic (and other…
View article: Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis
Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis Open
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease that lacks known pathogenesis, distinctive diagnostic criteria, and effective treatment options. Understanding the genetic (and other)…
View article: Profiling the Site of Protein CoAlation and Coenzyme A Stabilization Interactions
Profiling the Site of Protein CoAlation and Coenzyme A Stabilization Interactions Open
Coenzyme A (CoA) is a key cellular metabolite known for its diverse functions in metabolism and regulation of gene expression. CoA was recently shown to play an important antioxidant role under various cellular stress conditions by forming…
View article: Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients
Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients Open
Characterization of the risk factors associated with variability in the clinical outcomes of COVID-19 is important. Our previous study using genomic data identified a potential role of calcium and lipid homeostasis in severe COVID-19. This…
View article: Combinatorial analysis of phenotypic and clinical risk factors associated with hospitalized COVID-19 patients
Combinatorial analysis of phenotypic and clinical risk factors associated with hospitalized COVID-19 patients Open
1 Abstract Characterization of the risk factors associated with variability in the clinical outcomes of COVID-19 is important. Our previous study using genomic data identified a potential role of calcium and lipid homeostasis in severe COV…
View article: CATH functional families predict functional sites in proteins
CATH functional families predict functional sites in proteins Open
Motivation Identification of functional sites in proteins is essential for functional characterization, variant interpretation and drug design. Several methods are available for predicting either a generic functional site, or specific type…
View article: The COVID-19 PHARMACOME: A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization
The COVID-19 PHARMACOME: A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization Open
The SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community’s massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in the field of drug repurposing. …
View article: Artificial Intelligence in Oncology Drug Discovery and Development
Artificial Intelligence in Oncology Drug Discovery and Development Open
There exists a profound conflict at the heart of oncology drug development. The efficiency of the drug development process is falling, leading to higher costs per approved drug, at the same time personalised medicine is limiting the target…
View article: AI Enabled Precision Medicine: Patient Stratification, Drug Repurposing and Combination Therapies
AI Enabled Precision Medicine: Patient Stratification, Drug Repurposing and Combination Therapies Open
Access to huge patient populations with well-characterized datasets, coupled with novel analytical methods, enables the stratification of complex diseases into multiple distinct forms. Patients can be accurately placed into distinguishable…
View article: Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients
Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients Open
BACKGROUND Epidemiological studies indicate that as many as 20% of individuals who test positive for COVID-19 develop severe symptoms that can require hospitalization. These symptoms include low platelet count, severe hypoxia, increased in…
View article: Identification and Analysis of Shared Risk Factors in Sepsis and High Mortality Risk COVID-19 Patients
Identification and Analysis of Shared Risk Factors in Sepsis and High Mortality Risk COVID-19 Patients Open
BACKGROUND Coronavirus disease 2019 (COVID-19) is a novel coronavirus strain disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease is highly transmissible and severe disease including viral sepsis has …
View article: CATH functional families predict protein functional sites
CATH functional families predict protein functional sites Open
Motivation Identification of functional sites in proteins is essential for functional characterisation, variant interpretation and drug design. Several methods are available for predicting either a generic functional site, or specific type…
View article: PDBe-KB: a community-driven resource for structural and functional annotations
PDBe-KB: a community-driven resource for structural and functional annotations Open
The Protein Data Bank in Europe-Knowledge Base (PDBe-KB, https://pdbe-kb.org) is a community-driven, collaborative resource for literature-derived, manually curated and computationally predicted structural and functional annotations of mac…
View article: The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens Open
The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. Here we report on the results of the third CAFA challenge, CAF…
View article: CATH: expanding the horizons of structure-based functional annotations for genome sequences
CATH: expanding the horizons of structure-based functional annotations for genome sequences Open
This article provides an update of the latest data and developments within the CATH protein structure classification database (http://www.cathdb.info). The resource provides two levels of release: CATH-B, a daily snapshot of the latest str…