Sayumi Tahara
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View article: Oncogenic Functions of Alternatively Spliced MDM2-ALT2 Isoform in Retroperitoneal Liposarcoma
Oncogenic Functions of Alternatively Spliced MDM2-ALT2 Isoform in Retroperitoneal Liposarcoma Open
Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes of soft tissue sarcoma (STS). Complete surgical resection remains the mainstay treatment, while the high rate of locoregional recurrence constitutes the pred…
View article: Methylation-based subtypes of gastric cancer provide distinct prognostic impact in patients who receive chemotherapy
Methylation-based subtypes of gastric cancer provide distinct prognostic impact in patients who receive chemotherapy Open
High levels of cancer-specific aberrant promoter hypermethylation provide distinct clinicopathological features in gastric cancer (GC) patients. This study explored the molecular subtypes based on the cancer-specific aberrant promoter hype…
View article: Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research
Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research Open
Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, in vitro experiments are an essential approach to elucidate liposarcoma pathobiology. Conv…
View article: Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research
Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research Open
Background: Dedifferentiated liposarcoma is a formidable sarcoma subtype due to its high local recurrence rate and resistance to medical treatment. While 2D cell cultures are still commonly used, 3D cell culture systems have emerged as a p…
View article: Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma
Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma Open
Background/Aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as inten…
View article: In situ hybridization to detect DNA amplification in extracellular vesicles
In situ hybridization to detect DNA amplification in extracellular vesicles Open
EVs have emerged as an important component in tumour initiation, progression and metastasis. Although notable progresses have been made, the detection of EV cargoes remain significantly challenging for researchers to practically use; faste…
View article: Radiologic complications in a long-term survivor with Wilms tumor: a case report
Radiologic complications in a long-term survivor with Wilms tumor: a case report Open
Wilms tumor is a child-specific cancer with a 5-year survival rate exceeding 90%. We report the case of a 48-year-old man who survived after he was diagnosed with Wilms tumor at 3 years but died due to a circulatory disorder after radiatio…
View article: Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX
Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX Open
DNA damage caused by Helicobacter pylori infection and chronic inflammation or exposure to genotoxic agents is considered an important risk factor of gastric carcinogenesis. In this study, we have evaluated a short-term technique to detect…
View article: Pneumatosis intestinalis and hepatic portal venous gas associated with gas-forming bacterial translocation due to postoperative paralytic ileus
Pneumatosis intestinalis and hepatic portal venous gas associated with gas-forming bacterial translocation due to postoperative paralytic ileus Open
Rationale: Pneumatosis intestinalis (PI) and hepatic portal venous gas (HPVG) are rare but potentially lethal conditions in which gas pathologically accumulates in the portal vein and intestinal wall, respectively. Proposed mechanisms incl…
View article: DNA methylation accumulation in gastric mucosa adjacent to cancer after <i>Helicobacter pylori</i> eradication
DNA methylation accumulation in gastric mucosa adjacent to cancer after <i>Helicobacter pylori</i> eradication Open
Molecular irreversibleness with Helicobacter pylori ( H. pylori ) infection might have a role in gastric tumorigenesis after H. pylori eradication. We performed comprehensive DNA methylation profiling of gastric mucosa after H. pylori erad…
View article: PO-008 Accelerated DNA methylation in gastric mucosa adjacent to cancer after HELICOBACTER PYLORI eradication
PO-008 Accelerated DNA methylation in gastric mucosa adjacent to cancer after HELICOBACTER PYLORI eradication Open
Introduction The molecular irreversibleness with Helicobacter pylori ( H. pylori ) infection may have a role in gastric tumorigenesis after H. pylori eradication. We performed comprehensive DNA methylation profiling of gastric mucosa …
View article: Potential link between Fusobacterium enrichment and DNA methylation accumulation in the inflammatory colonic mucosa in ulcerative colitis
Potential link between Fusobacterium enrichment and DNA methylation accumulation in the inflammatory colonic mucosa in ulcerative colitis Open
Our findings suggest that Fusobacterium accelerates DNA methylation in specific groups of genes in the inflammatory colonic mucosa in UC.
View article: Morphologic characterization of residual DNA methylation in the gastric mucosa after <i>Helicobacter pylori</i> eradication
Morphologic characterization of residual DNA methylation in the gastric mucosa after <i>Helicobacter pylori</i> eradication Open
Residual DNA methylation in the gastric mucosa after Helicobacter pylori ( H. pylori ) eradication may have a role in gastric carcinogenesis. We examined the association between morphologic features and promoter methylation status of non‐n…
View article: Telomere Length in Leukocyte DNA in Gastric Cancer Patients and its Association with Clinicopathological Features and Prognosis
Telomere Length in Leukocyte DNA in Gastric Cancer Patients and its Association with Clinicopathological Features and Prognosis Open
Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.