Kiyoshi Sakai
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View article: Safety and Feasibility of Intravenous Administration of Autologous Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Children with Cerebral Palsy: A First-in-Human Phase I Clinical Trial (Interim Analysis)
Safety and Feasibility of Intravenous Administration of Autologous Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Children with Cerebral Palsy: A First-in-Human Phase I Clinical Trial (Interim Analysis) Open
Background Cerebral palsy (CP), often resulting from perinatal hypoxic-ischemic encephalopathy (HIE), is a lifelong neurological disorder with no curative treatment. Stem cells from human exfoliated deciduous teeth (SHED), derived from the…
View article: Efficacy and safety of tirzepatide in subjects with type 2 diabetes and chronic kidney disease: a prospective, two-arm observational study
Efficacy and safety of tirzepatide in subjects with type 2 diabetes and chronic kidney disease: a prospective, two-arm observational study Open
Background: Tirzepatide (TZP) has demonstrated efficacy for glycemic control and weight loss in subjects with type 2 diabetes (T2D). However, previous clinical trials were not conducted under the treatment of glucagon-like peptide-1 recept…
View article: A Novel <i>ARMC5</i> Germline Variant in Siblings With Primary Bilateral Macronodular Adrenal Hyperplasia and Colonic Adenomas
A Novel <i>ARMC5</i> Germline Variant in Siblings With Primary Bilateral Macronodular Adrenal Hyperplasia and Colonic Adenomas Open
We report 2 siblings with primary bilateral macronodular adrenal hyperplasia (PBMAH). Both case 1, a 61-year-old male, and case 2, his 54-year-old brother, presented with incidentally discovered multiple nodules in bilateral adrenal glands…
View article: Bilateral pleural effusion and right chylothorax after left cervical dissection: A case report
Bilateral pleural effusion and right chylothorax after left cervical dissection: A case report Open
View article: Soluble Siglec-9 Improves Intestinal Barrier Function in a Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis
Soluble Siglec-9 Improves Intestinal Barrier Function in a Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis Open
Background/Objectives: Metabolic dysfunction-associated steatohepatitis (MASH), characterized by liver inflammation, fibrosis, and fat accumulation, can develop into cirrhosis and liver cancer. Despite its increasing prevalence worldwide, …
View article: Case Report: Amelioration of severe metabolic dysfunction-associated steatohepatitis after switching from conventional GLP-1RAs to tirzepatide
Case Report: Amelioration of severe metabolic dysfunction-associated steatohepatitis after switching from conventional GLP-1RAs to tirzepatide Open
Metabolic dysfunction-associated steatohepatitis (MASH) has cardiometabolic risk factors, such as obesity and type 2 diabetes, and has been reported to have a potentially higher risk of mortality than conventional steatotic liver diseases.…
View article: Soluble Siglec-9 Improves Intestinal Barrier Function in a Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis
Soluble Siglec-9 Improves Intestinal Barrier Function in a Mouse Model of Metabolic Dysfunction-Associated Steatohepatitis Open
Background/Objectives: Metabolic dysfunction-associated steatohepatitis (MASH), characterized by liver inflammation, fibrosis, and fat accumulation, can develop into cirrhosis and liver cancer. Despite its increasing prevalence worldwide, …
View article: Efeitos Da Exposição a Poluentes Ambientais Sobre a Próstata: Um Estudo Sobre Os Ftalatos
Efeitos Da Exposição a Poluentes Ambientais Sobre a Próstata: Um Estudo Sobre Os Ftalatos Open
Com o avanço industrial, tecnológico e social, torna-se indiscutível que cada modificação da natureza, com o objetivo de beneficiar o ser humano, gera consequências não somente para o ambiente mas, também, para os indivíduos que a promover…
View article: Implant-supported fixed prostheses with cantilever: a systematic review and meta-analysis
Implant-supported fixed prostheses with cantilever: a systematic review and meta-analysis Open
View article: Conditioned medium of human mesenchymal stem cells affects stem cell senescence in osteoporosis
Conditioned medium of human mesenchymal stem cells affects stem cell senescence in osteoporosis Open
Systemic transplantation of mesenchymal stem cells (MSCs) and conditioned medium derived from MSCs have been reported to recover bone loss in animal models of osteoporosis; however, the underlying mechanisms remain unclear. We recently rep…
View article: Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia
Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia Open
Background Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of chemotherapy, with an estimated incidence of 65% and limited treatment options. Cyclophosphamide (CYP) is a common alopecia-inducing chemotherapy agent. Huma…
View article: Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse
Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse Open
Osteonecrosis of the femoral head (ONFH) is a type of ischemic osteonecrosis that causes pain, loss of function, and femoral head collapse. Here, we analyzed samples of femoral heads excised from patients with ONFH to clarify the relations…
View article: Asbestos in organochlorine insecticide powder sprinkled between pages of antiquarian books in a library in Japan
Asbestos in organochlorine insecticide powder sprinkled between pages of antiquarian books in a library in Japan Open
Librarians at a university had planned to check the collection prior to the library renovations that began in 2015. They had previous knowledge of the presence of a light greyish-white powder with an unpleasant odour (hereinafter referred …
View article: SEMI-QUANTITATIVE EVALUATION OF MASSETER MUSCLE STIFFNESS IN PATIENTS WITH TEMPOROMANDIBULAR DISORDERS USING STRAIN ELASTOGRAPHY
SEMI-QUANTITATIVE EVALUATION OF MASSETER MUSCLE STIFFNESS IN PATIENTS WITH TEMPOROMANDIBULAR DISORDERS USING STRAIN ELASTOGRAPHY Open
View article: Development and application of remote monitoring systems for tunneling works in conventional tunnel construction
Development and application of remote monitoring systems for tunneling works in conventional tunnel construction Open
The authors developed two remote monitoring systems and applied them to a mountain tunnel construction site: "T-iMonitor Tunnel" for excavation and "T-iMonitor Tunnel Concrete" for lining works. The former can monitor and record remotely t…
View article: Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study Open
View article: Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice
Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice Open
2-Ethyl-1-hexanol (2EH) is a volatile organic compound known to cause sick building syndrome. However, 2EH-induced hepatotoxicity has been mainly evaluated in experiments orally administering 2EH as a metabolite of di(2-ethylhexyl) phthala…
View article: Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis
Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Open
View article: Coexistence of Sjögren's syndrome and bilateral ranulas: A case report and review of the literature
Coexistence of Sjögren's syndrome and bilateral ranulas: A case report and review of the literature Open
Sjögren's syndrome and ranulas are relatively frequently occurring diseases. However, when they occur simultaneously, its clinical features and pathogenesis remain unclear. Here, we report a patient with bilateral ranulas. Magnetic resonan…
View article: Deterioration of modern concrete structures and asphalt pavements by respiratory action and trace quantities of organic matter
Deterioration of modern concrete structures and asphalt pavements by respiratory action and trace quantities of organic matter Open
In concrete structures (concrete), damage from cracks, deterioration, amorphization, and delamination occur in some structures, causing disaggregation (concrete changed to very fine particles) and hollowing out of the concrete. In concrete…
View article: Parallel disease activity of Behçet’s disease with renal and entero involvements: a case report
Parallel disease activity of Behçet’s disease with renal and entero involvements: a case report Open
View article: Verification of the Effectiveness of an SNP Marker in the Cholecystokinin Type A Receptor Gene for Improving Growth Traits in Okumino-kojidori Chickens
Verification of the Effectiveness of an SNP Marker in the Cholecystokinin Type A Receptor Gene for Improving Growth Traits in Okumino-kojidori Chickens Open
A significant association was reported between a single nucleotide polymorphism (SNP; AB604331, g.420 C>A) in the cholecystokinin type A receptor gene and growth traits in some Japanese slow-growing chickens. Demonstration tests of the gen…
View article: Bone regeneration using exosomes derived from hMSCs stimulated by hypoxia
Bone regeneration using exosomes derived from hMSCs stimulated by hypoxia Open
Background Mesenchymal stem cells (MSCs) secrete various kinds of soluble factors such as exosomes. Exosomes are nanoparticles and are thought to play essential roles in intercellular communication. We collected exosomes from the condition…
View article: Perioperative management of tooth extraction in a patient with congenital afibrinogenemia
Perioperative management of tooth extraction in a patient with congenital afibrinogenemia Open
Congenital afibrinogenemia is a hemorrhagic disease caused by synthesis disorder of fibrinogen (Fbg). We report the perioperative management of tooth extraction in a patient with congenital afibrinogenemia. The patient was a 13-year-old bo…
View article: Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant
Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant Open
Objectives 2-Ethyl-1-hexanol (2EH), a fragrance ingredient and a raw material for the production of plasticizer di(2-ethylhexyl) phthalate, is responsible for sick building syndrome (SBS). This review aims to clarify the 2EH characteristic…
View article: Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia
Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia Open
In nerve regeneration studies, various animal models are used to assess nerve regeneration. However, because of the difficulties in functional nerve assessment, a visceral nerve injury model is yet to be established. The superior laryngeal…
View article: Identification of the Novel Tooth-Specific Transcription Factor AmeloD
Identification of the Novel Tooth-Specific Transcription Factor AmeloD Open
Basic-helix-loop-helix (bHLH) transcription factors play an important role in various organs’ development; however, a tooth-specific bHLH factor has not been reported. In this study, we identified a novel tooth-specific bHLH transcription …
View article: Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene
Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene Open
Tooth enamel is mineralized through the differentiation of multiple dental epithelia including ameloblasts and the stratum intermedium (SI), and this differentiation is controlled by several signaling pathways. Previously, we demonstrated …
View article: Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns
Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns Open
Pannexin 3 (Panx3) and connexin 43 (Cx43; also known as GJA1) are two major gap junction proteins expressed in osteoblasts. Here, we studied their functional relationships in skeletal formation by generating Panx3−/− and Panx3−/−;Cx43−/− m…
View article: The association among ferruginous body, uncoated fibers, asbestos and non-asbestos fibers in lung tissue in terms of length
The association among ferruginous body, uncoated fibers, asbestos and non-asbestos fibers in lung tissue in terms of length Open
To demonstrate the correlations between the concentrations of ferruginous body as well as uncoated fiber both of which can be observed with phase-contrast microscope and the concentration of various inorganic fibers including asbestos whic…