Explanipedia

Development and in vitro evaluation of biomimetic injectable hydrogels from decellularized human nerves for central nervous system regeneration Open

Gopal Agarwal, Kennedy Moes, Christine E. Schmidt · 2025

Injuries to the central nervous system (CNS) often lead to persistent inflammation and limited regeneration. This study developed a clinically relevant injectable hydrogel derived from decellularized human peripheral nerves, with mechanica…

Development of a SnO2-based 44Ti/44Sc generator for medical applications Open

Christine E. Schmidt, Sam Groveman, Vanessa A. Sanders, Cathy S. Cutler, Jennifer A. Shusterman , et al. · 2024

Decellularized porcine peripheral nerve based injectable hydrogels as a Schwann cell carrier for injured spinal cord regeneration Open

Gopal Agarwal, Samantha Shumard, Michaela W. McCrary, Olivia Osborne, Jorge Mojica-Santiago , et al. · 2024

Objective. To develop a clinically relevant injectable hydrogel derived from decellularized porcine peripheral nerves and with mechanical properties comparable to native central nervous system (CNS) tissue to be used as a delivery vehicle …

Board 190A: A New Educational Experience: Community College Engineering and Music Students Create User-Friendly Music Theory Application for Education and Composition Open

Anita Riddle, Sierra Schmidt, Christine E. Schmidt, Karson Spencer, Nick Safai · 2024

Community college students invented, built, and implemented a user-friendly computer and mobile phone tool that enables musicians to compose and analyze music in the classroom and outside the classroom quickly. The key enabler was the coll…

Development and in Vitro Evaluation of Biomimetic Injectable Hydrogels from Decellularized Human Nerves for Central Nervous System Regeneration Open

Gopal Agarwal, Kennedy Moes, Christine E. Schmidt · 2024

Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight Open

Maddalena Parafati, Shelby Giza, Tushar Shenoy, Jorge Mojica-Santiago, Meghan Hopf , et al. · 2023

Temporal characterization of hyaluronidases after peripheral nerve injury Open

Mary Kasper, Bret Ellenbogen, Yuan Li, Christine E. Schmidt · 2023

Hyaluronic acid (HA) is ubiquitously found in biological tissues and mediates wound healing mechanisms after injury by promoting cell migration and proliferation. With the development of tissue-engineered neural therapeutics, including off…

Validation of Human Skeletal Muscle Tissue Chip Autonomous Platform to Model Age-Related Muscle Wasting in Microgravity Open

Maddalena Parafati, Shelby Giza, Tushar Shenoy, Jorge Mojica-Santiago, Meghan Hopf , et al. · 2023

Microgravity-induced muscle atrophy experienced by astronauts shares similar physiological changes to muscle wasting experienced by older adults, known as sarcopenia. These shared attributes provide a rationale for investigating microgravi…

Injectable Neural Hydrogel as in vivo Therapeutic Delivery Vehicle Open

Nora Hlavac, Deanna Bousalis, Emily Pallack, Yuan Li, Eleana Manousiouthakis , et al. · 2023

Development of a bioactive tunable hyaluronic-protein bioconjugate hydrogel for tissue regenerative applications Open

Mary Kasper, Madison Cydis, Abdullah Afridi, Bassam M. Smadi, Yuan Li , et al. · 2023

Hyaluronic acid-based hydrogels conjugated with a fibrinogen linker were found to contribute to faster scaffold degradation via active enzymatic breakdown, paving the pathway for use in a variety of multi-purpose tissue engineering applica…

Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells Open

Shelby Giza, Jorge Mojica-Santiago, Maddalena Parafati, Legrand K. Malany, Don Platt , et al. · 2022

Microphysiological systems (MPS), also referred to as tissue chips, incorporating 3D skeletal myobundles are a novel approach for physiological and pharmacological studies to uncover new medical treatments for sarcopenia. We characterize a…

Effects of Varied Stimulation Parameters on Adipose-Derived Stem Cell Response to Low-Level Electrical Fields Open

Nora Hlavac, Deanna Bousalis, Raffae N. Ahmad, Emily Pallack, Angelique Vela , et al. · 2021

Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications Open

Mary Kasper, Bret Ellenbogen, R. Hardy, Madison Cydis, Jorge Mojica-Santiago , et al. · 2021

Decellularized peripheral nerve as an injectable delivery vehicle for neural applications Open

Deanna Bousalis, Michaela W. McCrary, Natalie Vaughn, Nora Hlavac, Ashley Evering , et al. · 2021

Damage to the nervous system can result in loss of sensory and motor function, paralysis, or even death. To facilitate neural regeneration and functional recovery, researchers have employed biomaterials strategies to address both periphera…

Towards the Translation of Electroconductive Organic Materials for Regeneration of Neural Tissues Open

Eleana Manousiouthakis, Junggeon Park, John G. Hardy, Jae Young Lee, Christine E. Schmidt · 2021

Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films Open

Mark Ashton, Isabel C Appen, Melike Fırlak, Naomi E Stanhope, Christine E. Schmidt , et al. · 2020

The development of stimuli‐responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer‐based drug delivery devices enabling spatiotemporal control of the release of the d…

Extracellular Matrix Disparities in an Nkx2-5 Mutant Mouse Model of Congenital Heart Disease Open

Deanna Bousalis, Christopher S. Lacko, Nora Hlavac, Fariz F. Alkassis, Rebecca A. Wachs , et al. · 2020

Congenital heart disease (CHD) affects almost one percent of all live births. Despite diagnostic and surgical reparative advances, the causes and mechanisms of CHD are still primarily unknown. The extracellular matrix plays a large role in…

Development of novel apoptosis-assisted lung tissue decellularization methods Open

Young Hye Song, Mark A Maynes, Nora Hlavac, Daniel Visosevic, Kaitlyn O. Daramola , et al. · 2020

Decellularized tissues hold great potential for both regenerative medicine and disease modeling applications. The acellular extracellular matrix (ECM)-enriched scaffolds can be recellularized with patient-derived cells prior to transplanta…

Microtopographical patterns promote different responses in fibroblasts and Schwann cells: A possible feature for neural implants Open

Sahba Mobini, Cary A. Kuliasha, Zachary A. Siders, Nicole A. Bohmann, Syed‐Mustafa Jamal , et al. · 2020

The chronic reliability of bioelectronic neural interfaces has been challenged by foreign body reactions (FBRs) resulting in fibrotic encapsulation and poor integration with neural tissue. Engineered microtopographies could alleviate these…

Integration of flexible polyimide arrays into soft extracellular matrix-based hydrogel materials for a tissue-engineered electronic nerve interface (TEENI) Open

Benjamin S. Spearman, Cary A. Kuliasha, Jack W. Judy, Christine E. Schmidt · 2020

Polysaccharide-based films for the prevention of unwanted postoperative adhesions at biological interfaces Open

Sarah Mayes, Jessica Davis, Jessica Scott, Vanessa Aguilar, Scott A. Zawko , et al. · 2020

Progress toward finding the perfect match: hydrogels for treatment of central nervous system injury Open

Nora Hlavac, Mary Kasper, Christine E. Schmidt · 2020

Cover Image Open

Mohammad S. Azimi, Jessica M. Motherwell, Nicholas A. Hodges, Garret R. Rittenhouse, Dima Majbour , et al. · 2020

Cover Caption: The cover image is based on the Original Article Lymphatic-to-Blood Vessel Transition in Adult Microvascular Networks: A Discovery Made Possible by a Top-Down Approach to Biomimetic Model Development by Walter Murfee et al.,…

Preparation and evaluation of microfluidic magnetic alginate microparticles for magnetically templated hydrogels Open

Ishita Singh, Christopher S. Lacko, Zhiyuan Zhao, Christine E. Schmidt, Carlos Rinaldi · 2019

Tunable methacrylated hyaluronic acid‐based hydrogels as scaffolds for soft tissue engineering applications Open

Benjamin S. Spearman, Nikunj Agrawal, Andrés M. Rubiano, Chelsey S. Simmons, Sahba Mobini , et al. · 2019

Hyaluronic acid (HA)‐based biomaterials have been explored for a number of applications in biomedical engineering, particularly as tissue regeneration scaffolds. Crosslinked forms of HA are more robust and provide tunable mechanical proper…

Lymphatic‐to‐blood vessel transition in adult microvascular networks: A discovery made possible by a top‐down approach to biomimetic model development Open

Mohammad S. Azimi, Jessica M. Motherwell, Nicholas A. Hodges, Garret R. Rittenhouse, Dima Majbour , et al. · 2019

Objective Emerging areas of vascular biology focus on lymphatic/blood vessel mispatterning and the regulation of endothelial cell identity. However, a fundamental question remains unanswered: Can lymphatic vessels become blood vessels in a…

Magnetic particle templating of hydrogels: engineering naturally derived hydrogel scaffolds with 3D aligned microarchitecture for nerve repair Open

Christopher S. Lacko, Ishita Singh, Monica A. Wall, Andrew R. Garcia, Stacy Porvasnik , et al. · 2019

This simple and scalable technology has the flexibility to control tubular microstructure over long length scales, and thus the potential to meet the need for engineered scaffolds for tissue regeneration, including nerve guidance scaffolds.

Recent advances in nanotherapeutic strategies for spinal cord injury repair Open

Young Hye Song, Nikunj Agrawal, Jonathan M. Griffin, Christine E. Schmidt · 2018

The Open Source GAITOR Suite for Rodent Gait Analysis Open

Brittany Y. Jacobs, Emily H. Lakes, Alex J. Reiter, Spencer P. Lake, Trevor R. Ham , et al. · 2018

Neural Interfaces: Tissue‐Engineered Peripheral Nerve Interfaces (Adv. Funct. Mater. 12/2018) Open

Benjamin S. Spearman, Vidhi H. Desai, Sahba Mobini, Matthew D. McDermott, James B. Graham , et al. · 2018

In article number 1701713, Kevin J. Otto, Jack W. Judy, Christine E. Schmidt and co-workers review the latest in peripheral nerve interfaces, peripheral nerve tissue engineering, and the intersection of these fields to create regenerative …

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