Georg M. Schmölzer
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View article: Treatment guided by cerebral oximetry in mechanically ventilated newborns: a statistical analysis plan for step one of the SafeBoosC-IIIv randomised clinical trial
Treatment guided by cerebral oximetry in mechanically ventilated newborns: a statistical analysis plan for step one of the SafeBoosC-IIIv randomised clinical trial Open
ClinicalTrials.gov NCT05907317. First submitted on 8 June 2023, https://clinicaltrials.gov/study/NCT05907317.
View article: Chest compression during sustained inflation versus 3:1 compression-to-ventilation ratio during neonatal cardiopulmonary resuscitation of asphyxiated piglets
Chest compression during sustained inflation versus 3:1 compression-to-ventilation ratio during neonatal cardiopulmonary resuscitation of asphyxiated piglets Open
Use of the CC + SI technique during neonatal piglet resuscitation leads to a faster ROSC, with no difference in survival.
View article: Part 5: Neonatal Resuscitation: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Part 5: Neonatal Resuscitation: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Open
The guidelines in this document from the American Heart Association and the American Academy of Pediatrics focus upon optimal care of the newborn infant, including those who are proceeding to a normal transition from the fluid-filled uteri…
View article: Neonatal Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations
Neonatal Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations Open
The International Liaison Committee on Resuscitation continually reviews new, peer-reviewed cardiopulmonary resuscitation science and publishes comprehensive reviews every 5 years. The Neonatal Life Support chapter of the 2025 Internationa…
View article: Cardiopulmonary resuscitation with Synchronized Ventilation: A new technique of Neonatal Resuscitation that reduces time to return of spontaneous circulation in a neonatal porcine model
Cardiopulmonary resuscitation with Synchronized Ventilation: A new technique of Neonatal Resuscitation that reduces time to return of spontaneous circulation in a neonatal porcine model Open
Introduction Current neonatal resuscitation guidelines recommend a 3:1 Compression:Ventilation ratio (3:1 C:V) during cardiopulmonary resuscitation. One of the concerns with 3:1 C:V is lung derecruitment, which contributes to a delay in ac…
View article: Effects of Intramuscular Vasopressin on Pharmacokinetics and Pharmacodynamics in Healthy Neonatal Piglets: A Dose–Response Study
Effects of Intramuscular Vasopressin on Pharmacokinetics and Pharmacodynamics in Healthy Neonatal Piglets: A Dose–Response Study Open
Background: Neonatal resuscitation guidelines recommend the use of the vasopressor epinephrine during neonatal cardiopulmonary resuscitation (CPR); however, vasopressin may be a potential alternative. Successful neonatal CPR requires rapid…
View article: Volume targeted mask ventilation during simulated neonatal resuscitation – A randomized crossover manikin study
Volume targeted mask ventilation during simulated neonatal resuscitation – A randomized crossover manikin study Open
In a neonatal manikin model, VTV-PPV with the NextStepTM using a two-hand hold reduced mask leak compared to the T-piece without RFM guidance.
View article: Dose-Related Pharmacokinetic and Pharmacodynamic Effects of Intramuscular Epinephrine in Healthy Neonatal Piglets
Dose-Related Pharmacokinetic and Pharmacodynamic Effects of Intramuscular Epinephrine in Healthy Neonatal Piglets Open
Background: Epinephrine is currently the only vasopressor recommended during neonatal cardiopulmonary resuscitation (CPR). Rapid vasopressor administration is critical during CPR; however, establishing vascular access can take several minu…
View article: Therapeutic Hypothermia in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis
Therapeutic Hypothermia in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis Open
In low- and middle-income countries, in hospitals using defined protocols and having capacity for intensive care and follow-up, TH has possible benefit for infants ≥37 weeks gestational age for important secondary outcomes, including NDI.
View article: Impact of resuscitation with 100% oxygen during physiological-based cord clamping or immediate cord clamping on lung inflammation and injury
Impact of resuscitation with 100% oxygen during physiological-based cord clamping or immediate cord clamping on lung inflammation and injury Open
Background We examined whether physiological based cord clamping (PBCC) reduces oxygen-induced lung inflammation compared to immediate cord clamping (ICC) in preterm lambs ventilated with 100% oxygen for 10 min after birth. Methods Instrum…
View article: Tidal volume delivery during chest compression with either an endotracheal tube or supraglottic airway in a porcine animal model
Tidal volume delivery during chest compression with either an endotracheal tube or supraglottic airway in a porcine animal model Open
Purpose: The 2023 Consensus of Science and Treatment Recommendations states that a supraglottic airway (SGA) device can be used to deliver positive pressure ventilation. However, it is unclear if a SGA can effectively be used during chest …
View article: Automated oxygen control in preterm babies on respiratory support: protocol for a randomised crossover trial
Automated oxygen control in preterm babies on respiratory support: protocol for a randomised crossover trial Open
Introduction Respiratory support is frequently needed for babies admitted to the neonatal intensive care unit. Among them, preterm babies are most likely to have issues of respiratory distress, and they may need invasive or non-invasive br…
View article: Acupuncture for neonatal abstinence syndrome in newborn infants
Acupuncture for neonatal abstinence syndrome in newborn infants Open
The limited available evidence is insufficient to establish the benefits and harms of acupuncture for the management of NAS in newborn infants. Both studies we included in this review assessed non-invasive acupuncture and reported no adver…
View article: Chest Compression Superimposed with Sustained Inflation or 3:1 Compression/Ventilation Ratio During Neonatal Cardiopulmonary Resuscitation in the Delivery Room: A Systematic Review and Meta-Analysis
Chest Compression Superimposed with Sustained Inflation or 3:1 Compression/Ventilation Ratio During Neonatal Cardiopulmonary Resuscitation in the Delivery Room: A Systematic Review and Meta-Analysis Open
Background: Current resuscitation guidelines recommend a 3:1 chest compression/ventilation (C:V) ratio, which is associated with high morbidity and mortality. An alternative might be continuous chest compression superimposed with high dist…
View article: Hand position during chest compression in infantile piglets – Do you need to encircle the chest with the 2-thumb-technique?
Hand position during chest compression in infantile piglets – Do you need to encircle the chest with the 2-thumb-technique? Open
The 2-thumb- and 2-thumb-encircling-techniques produced significantly higher ejection fraction, carotid blood flow, and dp/dtmax, and lower dp/dtmin compared to the 2-finger- and one-hand-techniques. Encircling the chest during the 2-thumb…
View article: Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes of administration in a neonatal piglet model
Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes of administration in a neonatal piglet model Open
Epinephrine is the only recommended vasopressor during neonatal cardiopulmonary resuscitation. However, there are concerns about the potential adverse effects of epinephrine, which might hamper efficacy during cardiopulmonary resuscitation…
View article: 72 Hospital level of service, rural-urban hospital location, and neonatal resuscitation interventions at birth: A population-based study in Alberta, Canada from 2000-2020
72 Hospital level of service, rural-urban hospital location, and neonatal resuscitation interventions at birth: A population-based study in Alberta, Canada from 2000-2020 Open
Background Advanced neonatal resuscitation interventions (ANRIs: endotracheal intubation, chest compressions, and epinephrine) are rarely needed for infants born at ≥34 weeks gestational age (GA). However, healthcare providers (HCPs) in co…
View article: Impact of in situ simulation training on quality of postnatal stabilization and resuscitation—a before-and-after, non-controlled quality improvement study
Impact of in situ simulation training on quality of postnatal stabilization and resuscitation—a before-and-after, non-controlled quality improvement study Open
This study aimed to evaluate the impact of in situ simulation-based training on quality indicators of patient care at a level IV neonatal intensive care unit. A before-and-after, non-controlled quality improvement study was performed at th…
View article: Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study
Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study Open
Objective Intravenous epinephrine administration is preferred during neonatal resuscitation, but may not always be rapidly administered due to lack of equipment or trained staff. We aimed to compare the time to return of spontaneous circul…
View article: Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes in a neonatal piglet model
Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes in a neonatal piglet model Open
Epinephrine is the only recommended vasopressor during neonatal cardiopulmonary resuscitation. However, there are concerns about the potential adverse effects of epinephrine, which might hamper efficacy during cardiopulmonary resuscitation…