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View article: Charge identification of fragments produced in 16O beam interactions at 200 MeV/n and 400 MeV/n on C and C2H4 targets
Charge identification of fragments produced in 16O beam interactions at 200 MeV/n and 400 MeV/n on C and C2H4 targets Open
Introduction: Charged Particle Therapy plays a key role in the treatment of deep-seated tumours, because of the advantageous energy deposition culminating in the Bragg peak. However, knowledge of the dose delivered in the entrance channel …
View article: Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy
Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy Open
The treatment of deep-seated tumours with electrons of very high energies (VHEE, 70–150 MeV) has already been explored in the past, suggesting that a dosimetric coverage comparable with state-of-the-art proton (PT) or photon radiotherapy (…
View article: GPU-accelerated Monte Carlo simulation of electron and photon interactions for radiotherapy applications
GPU-accelerated Monte Carlo simulation of electron and photon interactions for radiotherapy applications Open
Objective . The Monte Carlo simulation software is a valuable tool in radiation therapy, in particular to achieve the needed accuracy in the dose evaluation for the treatment plans optimisation. The current challenge in this field is the t…
View article: Elemental fragmentation cross sections for a 16O beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT ΔE-TOF detectors
Elemental fragmentation cross sections for a 16O beam of 400 MeV/u kinetic energy interacting with a graphite target using the FOOT ΔE-TOF detectors Open
The study of nuclear fragmentation plays a central role in many important applications: from the study of Particle Therapy (PT) up to radiation protection for space (RPS) missions and the design of shielding for nuclear reactors. The Fragm…
View article: In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO
In-vivo range verification analysis with in-beam PET data for patients treated with proton therapy at CNAO Open
Morphological changes that may arise through a treatment course are probably one of the most significant sources of range uncertainty in proton therapy. Non-invasive in-vivo treatment monitoring is useful to increase treatment quality. The…
View article: Deep Seated Tumour Treatments With Electrons of High Energy Delivered at FLASH Rates: The Example of Prostate Cancer
Deep Seated Tumour Treatments With Electrons of High Energy Delivered at FLASH Rates: The Example of Prostate Cancer Open
Different therapies are adopted for the treatment of deep seated tumours in combination or as an alternative to surgical removal or chemotherapy: radiotherapy with photons (RT), particle therapy (PT) with protons or even heavier ions like …
View article: Localization of anatomical changes in patients during proton therapy with in‐beam PET monitoring: A voxel‐based morphometry approach exploiting Monte Carlo simulations
Localization of anatomical changes in patients during proton therapy with in‐beam PET monitoring: A voxel‐based morphometry approach exploiting Monte Carlo simulations Open
Purpose In‐beam positron emission tomography (PET) is one of the modalities that can be used for in vivo noninvasive treatment monitoring in proton therapy. Although PET monitoring has been frequently applied for this purpose, there is sti…
View article: Enhancing the understanding of fragmentation processes in hadrontherapy and radioprotection in space with the FOOT experiment
Enhancing the understanding of fragmentation processes in hadrontherapy and radioprotection in space with the FOOT experiment Open
During proton and carbon ions cancer treatment, nuclear interactions of the beam nuclei with the patient tissues always occur: the former leads to target fragmentation only, the latter to both projectile and target fragments production. In…
View article: Search for stellar collapse with the MACRO detector at Gran Sasso
Search for stellar collapse with the MACRO detector at Gran Sasso Open
The first MACRO supermodule commenced data taking in February 1989. Two complementary trigger and readout systems have been used to monitor the horizontal scintillation counters, which contain 42 tonnes ({approximately}1 ktonne for the ful…
View article: Monitoring Carbon Ion Beams Transverse Position Detecting Charged Secondary Fragments: Results From Patient Treatment Performed at CNAO
Monitoring Carbon Ion Beams Transverse Position Detecting Charged Secondary Fragments: Results From Patient Treatment Performed at CNAO Open
Particle therapy in which deep seated tumours are treated using 12 C ions (Carbon Ions RadioTherapy or CIRT) exploits the high conformity in the dose release, the high relative biological effectiveness and low oxygen enhancement ratio of s…
View article: PAPRICA: The Pair Production Imaging Chamber—Proof of Principle
PAPRICA: The Pair Production Imaging Chamber—Proof of Principle Open
In Particle Therapy, safety margins are applied around the tumor to account for the beam range uncertainties and ensure an adequate dose coverage of the tumor volume during the therapy. The reduction of safety margins is in great demand in…
View article: Feasibility Study of a Prostate Cancer FLASH Therapy Treatment With Electrons of High Energy
Feasibility Study of a Prostate Cancer FLASH Therapy Treatment With Electrons of High Energy Open
Prostate cancer is among the most common cancers in men and one of the leading causes of death worldwide. Different therapies are adopted for its treatment and generally radiotherapy with photons (RT) is the preferred solution in almost al…
View article: Detection of Interfractional Morphological Changes in Proton Therapy: A Simulation and In Vivo Study With the INSIDE In-Beam PET
Detection of Interfractional Morphological Changes in Proton Therapy: A Simulation and In Vivo Study With the INSIDE In-Beam PET Open
In particle therapy, the uncertainty of the delivered particle range during the patient irradiation limits the optimization of the treatment planning. Therefore, an in vivo treatment verification device is required, not only to improve the…
View article: Prostate cancer FLASH therapy treatments with electrons of high energy: A feasibility study
Prostate cancer FLASH therapy treatments with electrons of high energy: A feasibility study Open
Anna A. Oleshkevich, Specific features of change in enzymate activity in
View article: Charge identification of fragments with the emulsion spectrometer of the FOOT experiment
Charge identification of fragments with the emulsion spectrometer of the FOOT experiment Open
The FOOT (FragmentatiOn Of Target) experiment is an international project designed to carry out the fragmentation cross-sectional measurements relevant for charged particle therapy (CPT), a technique based on the use of charged particle be…
View article: The MONDO Tracker: Characterisation and Study of Secondary Ultrafast Neutrons Production in Carbon Ion Radiotherapy
The MONDO Tracker: Characterisation and Study of Secondary Ultrafast Neutrons Production in Carbon Ion Radiotherapy Open
Secondary neutrons produced in particle therapy (PT) treatments are responsible for the delivery of a large fraction of the out-of-target dose as they feebly interact with the patient body. To properly account for their contribution to the…
View article: The FragmentatiOn Of Target Experiment (FOOT) and its DAQ system
The FragmentatiOn Of Target Experiment (FOOT) and its DAQ system Open
The FragmentatiOn Of Target (FOOT) experiment aims to provide precise nuclear cross-section measurements for two different fields: hadrontherapy and radio-protection in space. The main reason is the important role the nuclear fragmentation…
View article: FRED: a fast Monte Carlo code on GPU for quality control in Particle Therapy
FRED: a fast Monte Carlo code on GPU for quality control in Particle Therapy Open
Charged Particle Therapy is a non-invasive technique for radio-resistant tumor treatment performed with protons or light ions, aiming to deliver a high precision treatment. Compared to conventional radiotherapy, ions allow for a higher dos…
View article: Performance of the ToF detectors in the foot experiment
Performance of the ToF detectors in the foot experiment Open
The FOOT (FragmentatiOn Of Target) experiment aims to determine the fragmentation cross-sections of nuclei of interest for particle therapy and radioprotection in space. The apparatus is composed of several detectors that allow fragment id…
View article: Characterisation of the secondary-neutron production in particle therapy treatments with the MONDO tracking detector
Characterisation of the secondary-neutron production in particle therapy treatments with the MONDO tracking detector Open
Particle Therapy (PT) is a non-invasive technique that exploits charged light ions for the irradiation of tumours that cannot be effectively treated with surgery or conventional radiotherapy. While the largest dose fraction is released to …
View article: In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler)
In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler) Open
The use of C, He and O ions as projectiles in Particle Therapy (PT) treatments is getting more and more widespread as a consequence of their enhanced relative biological effectiveness and oxygen enhancement ratio, when compared to the prot…
View article: FOOT: a new experiment to measure nuclear fragmentation at intermediate energies
FOOT: a new experiment to measure nuclear fragmentation at intermediate energies Open
Charged particle therapy exploits proton or 12C beams to treat deep-seated solid
\ntumors. Due to the advantageous characteristics of charged particles energy deposition in matter,
\nthe maximum of the dose is released to the tumor at the …
View article: Ion charge separation with new generation of nuclear emulsion films
Ion charge separation with new generation of nuclear emulsion films Open
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel a…