Scot P. Ouellette
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View article: Characterization of the Cell Division-Associated Peptidoglycan Amidase AmiA of <i>Chlamydia trachomatis</i>
Characterization of the Cell Division-Associated Peptidoglycan Amidase AmiA of <i>Chlamydia trachomatis</i> Open
Chlamydia is an obligate intracellular bacterium that differentiates between infectious, non-dividing EBs and non-infectious, dividing RBs. Pathogenic Chlamydia species are unusual in lacking a peptidoglycan sacculus, yet they do synthesiz…
View article: Author response: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
Author response: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
View article: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB). However, the molecular mechanisms governing the transitions between these…
View article: Author response: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
Author response: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
View article: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB). However, the molecular mechanisms governing the transitions between these…
View article: The SWIB domain-containing DNA topoisomerase I of <i>Chlamydia trachomatis</i> mediates DNA relaxation
The SWIB domain-containing DNA topoisomerase I of <i>Chlamydia trachomatis</i> mediates DNA relaxation Open
Chlamydia trachomatis has a DNA topoisomerase I with a unique C-terminal domain (CTD) homologous to eukaryotic SWIB domains. This study focused on determining the function of the SWIB domain-containing TopA from C. trachomatis (CtTopA). We…
View article: <i>Chlamydia</i> iron starvation links nutritional immunity to pathogen recognition
<i>Chlamydia</i> iron starvation links nutritional immunity to pathogen recognition Open
Nutritional immunity is an antimicrobial strategy that evolved to starve pathogens of essential nutrients, with death as the desired outcome. Here, we report that transient iron starvation of the obligate intracellular pathogen Chlamydia t…
View article: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB). However, the molecular mechanisms governing the transitions between these…
View article: Author Response: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
Author Response: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
View article: FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis
FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis Open
Chlamydia trachomatis serovar L2 ( Ct), an obligate intracellular bacterium that does not encode FtsZ, divides by a polarized budding process. In the absence of FtsZ, we show that FtsK, a chromosomal translocase, is critical for divisome a…
View article: Author response: FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis
Author response: FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis Open
View article: FtsK is Critical for the Assembly of the Unique Divisome Complex of the FtsZ-less Chlamydia trachomatis
FtsK is Critical for the Assembly of the Unique Divisome Complex of the FtsZ-less Chlamydia trachomatis Open
Chlamydia trachomatis serovar L2 (Ct), an obligate intracellular bacterium that does not encode FtsZ, divides by a polarized budding process. In the absence of FtsZ, we show that FtsK, a chromosomal translocase, is critical for divisome as…
View article: Author response: FtsK is Critical for the Assembly of the Unique Divisome Complex of the FtsZ-less Chlamydia trachomatis
Author response: FtsK is Critical for the Assembly of the Unique Divisome Complex of the FtsZ-less Chlamydia trachomatis Open
View article: The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB). However, the molecular mechanisms governing the transitions between these…
View article: Author response: Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
Author response: Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
View article: Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis Open
The obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB). However, the molecular mechanisms governing the transitions between these…
View article: Author response: Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression
Author response: Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression Open
View article: Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression
Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression Open
Chlamydia trachomatis is an obligate intracellular bacterial pathogen with a unique developmental cycle. It differentiates between two functional and morphological forms: the elementary body (EB) and the reticulate body (RB). The signals t…
View article: Effect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions
Effect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions Open
Chlamydia is an obligate intracellular bacterial pathogen that develops within a membrane-bound vacuole called an inclusion. Throughout its developmental cycle, Chlamydia modifies the inclusion membrane (IM) with type III secreted (T3S) me…
View article: Author response: Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression
Author response: Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression Open
View article: Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression
Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression Open
Chlamydia trachomatis is an obligate intracellular bacterial pathogen with a unique developmental cycle. It differentiates between two functional and morphological forms: elementary body (EB) and reticulate body (RB). The signals that trig…
View article: The SWIB domain-containing DNA topoisomerase I of<i>Chlamydia trachomatis</i>mediates DNA relaxation
The SWIB domain-containing DNA topoisomerase I of<i>Chlamydia trachomatis</i>mediates DNA relaxation Open
The obligate intracellular bacterial pathogen, Chlamydia trachomatis (Ct), has a distinct DNA topoisomerase I (TopA) with a C-terminal domain (CTD) homologous to eukaryotic SWIB domains. Despite the lack of sequence similarity at the CTDs …
View article: FtsK Initiates the Assembly of a Unique Divisome Complex in the FtsZ-less Chlamydia trachomatis
FtsK Initiates the Assembly of a Unique Divisome Complex in the FtsZ-less Chlamydia trachomatis Open
Chlamydia trachomatis serovar L2 (Ct), an obligate intracellular bacterium that does not encode FtsZ, divides by a polarized budding process. In the absence of FtsZ, we show that divisome assembly in Ct is initiated by FtsK, a chromosomal …
View article: FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis
FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis Open
Chlamydia trachomatis serovar L2 ( Ct), an obligate intracellular bacterium that does not encode FtsZ, divides by a polarized budding process. In the absence of FtsZ, we show that FtsK, a chromosomal translocase, is critical for divisome a…
View article: Effect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions
Effect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions Open
Chlamydia is an obligate intracellular bacterial pathogen that develops within a membrane-bound vacuole called an inclusion. Throughout its developmental cycle, Chlamydia modifies the inclusion membrane (IM) with type III secreted (T3S) me…
View article: Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in <i>Chlamydia trachomatis</i>
Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in <i>Chlamydia trachomatis</i> Open
Chlamydia is an obligate intracellular bacterium that undergoes a complex biphasic developmental cycle, alternating between the smaller, infectious, non-dividing elementary body (EB) and the larger, non-infectious but dividing reticulate b…
View article: Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development in <i>Chlamydia trachomatis</i>
Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development in <i>Chlamydia trachomatis</i> Open
Partner switching mechanisms (PSMs) are signal transduction systems comprised of a sensor phosphatase (RsbU), an anti-sigma factor (RsbW, kinase), an anti-anti-sigma factor (RsbV, the RsbW substrate), and a target sigma factor. Chlamydia s…
View article: FtsK is Critical for the Assembly of the Unique Divisome Complex of the FtsZ-less <i>Chlamydia trachomatis</i>
FtsK is Critical for the Assembly of the Unique Divisome Complex of the FtsZ-less <i>Chlamydia trachomatis</i> Open
Chlamydia trachomatis serovar L2 (Ct), an obligate intracellular bacterium that does not encode FtsZ, divides by a polarized budding process. In the absence of FtsZ, we show that FtsK, a chromosomal translocase, is critical for divisome as…
View article: <i>Chlamydia trachomatis</i> Inc Ct226 is vital for FLI1 and LRRF1 recruitment to the chlamydial inclusion
<i>Chlamydia trachomatis</i> Inc Ct226 is vital for FLI1 and LRRF1 recruitment to the chlamydial inclusion Open
The obligate intracellular pathogen, Chlamydia trachomatis , establishes an intracellular niche within a host membrane-derived vacuole called the chlamydial inclusion. From within this inclusion, C. trachomatis orchestrates numerous host-p…
View article: Reviewer #3 (Public Review): Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression
Reviewer #3 (Public Review): Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression Open
Chlamydia trachomatis is an obligate intracellular bacterial pathogen with a unique developmental cycle. It differentiates between two functional and morphological forms: elementary body (EB) and reticulate body (RB). The signals that trig…