Christiaan Scott
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View article: (ID: 61) Antimicrobial stewardship interventions involving community pharmacy teams: a scoping review
(ID: 61) Antimicrobial stewardship interventions involving community pharmacy teams: a scoping review Open
Introduction Antimicrobial stewardship (AMS) is defined by the World Health Organization as “a coherent set of actions which promotes the responsible use of antimicrobials” [1]. The involvement of community pharmacy (CP) teams in AMS-relat…
View article: Medical guidelines for fibrodysplasia ossificans progressiva
Medical guidelines for fibrodysplasia ossificans progressiva Open
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. Present management summ…
View article: Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa
Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa Open
Background Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short-term effects have been documented but little data exist on …
View article: Exploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers
Exploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers Open
Background There are limited studies of juvenile dermatomyositis (JDM) in low and middle-income countries (LMIC). Many demonstrate delays to care, high prevalence of severe manifestations, and high mortality. Given the disease-associated d…
View article: Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus
Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus Open
Objectives Our current understanding of the genetic architecture of childhood-onset SLE (cSLE) is limited by a dearth of comprehensive genomic studies in cSLE. We have quantified the number of known rare and common SLE risk variants in a d…
View article: Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project
Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project Open
Objective To assess current treatment in macrophage activation syndrome (MAS) worldwide and to highlight any areas of major heterogeneity of practice. Methods A systematic literature search was performed in both EMBASE and PubMed databases…
View article: A quantitative comparison between the essential medicines for rheumatic diseases in children and young people in Africa and the WHO model list
A quantitative comparison between the essential medicines for rheumatic diseases in children and young people in Africa and the WHO model list Open
Background The World Health Organisation Essential Medicines List (WHO EML) guides National Essential Medicines Lists and Standard Treatment Guidelines for clearly identified disease priorities especially in low- and middle-income countrie…
View article: Pediatric rheumatology education: the virtual frontier a review
Pediatric rheumatology education: the virtual frontier a review Open
Background Many children with rheumatic and musculoskeletal diseases are unrecognized. Identifying these children requires health care provider awareness, knowledge, and skills to recognize disease features and how (and when) to refer to s…
View article: Barriers and facilitators to medical care retention for pediatric systemic lupus erythematosus in South Africa: a qualitative study
Barriers and facilitators to medical care retention for pediatric systemic lupus erythematosus in South Africa: a qualitative study Open
Background Systemic lupus erythematosus (SLE) is a life-threatening, chronic, autoimmune disease requiring long term subspecialty care due to its complex and chronic nature. Childhood-onset SLE (cSLE) is more severe than adult-onset, and t…
View article: Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force Open
cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
View article: Screening practices, efficacy, safety and adherence to biologic therapies in a South African tertiary hospital
Screening practices, efficacy, safety and adherence to biologic therapies in a South African tertiary hospital Open
Introduction The high cost and concern of adverse events, particularly infections, limit the use of biologic therapies. We undertook this retrospective study to document their use for immune-mediated diseases, and explore the screening pra…
View article: Rocky Mountain Spotted Fever Associated With Cardiac Arrhythmias
Rocky Mountain Spotted Fever Associated With Cardiac Arrhythmias Open
Rickettsial infection, known as Rocky Mountain spotted fever, is a challenging diagnosis as early clinical manifestations are difficult to distinguish from viral illnesses. Symptoms at presentation depend on the organs involved, ranging fr…
View article: Most Fractures Treated Nonoperatively in Individuals With Fibrodysplasia Ossificans Progressiva Heal With a Paucity of Flareups, Heterotopic Ossification, and Loss of Mobility
Most Fractures Treated Nonoperatively in Individuals With Fibrodysplasia Ossificans Progressiva Heal With a Paucity of Flareups, Heterotopic Ossification, and Loss of Mobility Open
Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare genetic disorder with episodic and progressive heterotopic ossification. Tissue trauma is a major risk factor for flareups, heterotopic ossification (HO), and loss of m…
View article: Pancreatic Dysfunction Masquerading as an Insulinoma
Pancreatic Dysfunction Masquerading as an Insulinoma Open
Insulinoma is a rare neuroendocrine tumor that overproduces insulin, resulting in hypoglycemic symptoms. Elevated C-peptide levels in the absence of sulfonylurea use indicate insulinoma. Treatment is usually glucose administration and if t…
View article: OA39 Development of a Childhood Lupus Low Disease Activity State definition: recommendations from the International Childhood Lupus Treat-to-Target Task Force
OA39 Development of a Childhood Lupus Low Disease Activity State definition: recommendations from the International Childhood Lupus Treat-to-Target Task Force Open
Background/Aims International interest in development of treat-to-target (T2T) in both childhood-onset systemic lupus erythematosus (cSLE) and adult-onset SLE (aSLE) is increasing. T2T could facilitate more effective and structured use of …
View article: 72 Distinguishing features of MIS-C to other paediatric febrile diseases in the acute setting
72 Distinguishing features of MIS-C to other paediatric febrile diseases in the acute setting Open
Background Multisystem inflammatory syndrome in children (MIS-C) presents with fever, shock, rash, abdominal pain and raised inflammatory markers, as well as common features of inflammatory childhood illnesses. In the acute setting, especi…
View article: 71 Estimation of incidence of MIS-C in Cape Town, South Africa
71 Estimation of incidence of MIS-C in Cape Town, South Africa Open
Background Multisystem inflammatory syndrome is a severe manifestation of SARS-CoV-2 in children. The incidence of MIS-C after SARS-CoV-2 infection is poorly understood. There are very few cohorts describing MIS-C in Africa despite MIS-C b…
View article: IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort Open
Introduction Multisystem inflammatory syndrome in children (MIS-C) is a severe acute inflammatory reaction to SARS-CoV-2 infection in children. There is a lack of data describing differential expression of immune genes in MIS-C compared to…
View article: The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa
The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa Open
The effects of SARS-CoV-2 variants on disease phenotype and severity of multisystem inflammatory syndrome in children (MIS-C) are unknown. We compared the clinical phenotype of MIS-C in 129 South African children across four distinct (Ance…