Scott A. Fields
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View article: Systematic data capture reduces the need for source data verification: exploratory analysis from a phase 2 multicenter randomized controlled platform trial
Systematic data capture reduces the need for source data verification: exploratory analysis from a phase 2 multicenter randomized controlled platform trial Open
Background The COVID-19 pandemic gave rise to clinical trials focused on systematic, accurate primary data capture, and reduced reliance on source data verification (SDV). Here, we report on a natural experiment that allowed us to assess t…
View article: Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Open
Importance Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates. Objective To determine whether aceta…
View article: Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial
Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial Open
Quantum Leap Healthcare Collaborative is the trial sponsor. Funding for this trial has come from: the COVID R&D Consortium, Allergan, Amgen Inc., Takeda Pharmaceutical Company, Implicit Bioscience, Johnson & Johnson, Pfizer Inc., Roche/Gen…
View article: Psychological Impact of Coronavirus Disease-2019 on Healthcare Workers
Psychological Impact of Coronavirus Disease-2019 on Healthcare Workers Open
Purpose We studied the psychological impact of the coronavirus disease-2019 (COVID-19) on employees at an urban tertiary care center in the United States' mid-Atlantic region. Methods A Research Electronic Data Capture, or REDCap, survey w…
View article: Measuring the Effects of Social Risks on Patient Health Outcomes — A PCORnet® Study
Measuring the Effects of Social Risks on Patient Health Outcomes — A PCORnet® Study Open
How can people use the results?Health systems can include data on social risks to improve how well measures assess quality of care.
View article: Clinical Quality Measure Exchange is Not Easy
Clinical Quality Measure Exchange is Not Easy Open
The secure transfer of standardized, physician-level quality measures from 4 health systems with mature measure processes proved difficult. There were many errors that required human intervention and manual repair, precluding full automati…
View article: Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial
Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial Open
Memantine has been used off-label to treat frontotemporal lobar degeneration (FTD). A previous 26 week open label study suggested a transient, modest benefit on neuropsychiatric symptoms as measured by the Neuropsychiatric Inventory (NPI).
View article: Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics
Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics Open
ClinicalTrials.gov identifier: NCT01742065.
View article: Building Meaningful Patient Engagement in Research
Building Meaningful Patient Engagement in Research Open
Background: Strategies to engage patients to improve and enhance research and clinical care are increasingly being implemented in the United States, yet little is known about best practices for or the impacts of meaningful patient engageme…
View article: Response: Re: Patient-Provider Communication: Does Electronic Messaging Reduce Incoming Telephone Calls?
Response: Re: Patient-Provider Communication: Does Electronic Messaging Reduce Incoming Telephone Calls? Open
To the Editor: We appreciate the thoughtful correspondence. Our article addresses the question of what would happen to phone call volume in the face of expanding electronic messaging. Although we offered multiple hypotheses about why we ha…
View article: Patient–Provider Communication: Does Electronic Messaging Reduce Incoming Telephone Calls?
Patient–Provider Communication: Does Electronic Messaging Reduce Incoming Telephone Calls? Open
Implementation and increased use of electronic patient-to-provider messaging was associated with increased use of telephone calls in 2 of the study clinics. While practices are increasingly making the decision of whether to implement a pat…
View article: The Impact of Tobacco Smoking on One Year Patient Outcomes at a Family Medicine Residency Clinic
The Impact of Tobacco Smoking on One Year Patient Outcomes at a Family Medicine Residency Clinic Open
Objectives: In Appalachia, tobacco smoking rates are significantly higher than the United States average, and many of the comorbidities that exist with tobacco are prominent. The researchers investigated the impact of tobacco smoking on pa…
View article: SR-2P Vaginal Microbicide Gel Provides Protection against Herpes Simplex Virus 2 When Administered as a Combined Prophylactic and Postexposure Therapeutic
SR-2P Vaginal Microbicide Gel Provides Protection against Herpes Simplex Virus 2 When Administered as a Combined Prophylactic and Postexposure Therapeutic Open
Previously, we demonstrated that a single prophylactic dose of SR-2P, a novel dual-component microbicide gel comprising acyclovir and tenofovir, led to a modest increase in mouse survival following a lethal challenge of herpes simplex viru…