Scott A. Katzman
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View article: Intra-articular injection of an extended-release flavopiridol formulation represents a potential alternative to other intra-articular medications for treating equine joint disease
Intra-articular injection of an extended-release flavopiridol formulation represents a potential alternative to other intra-articular medications for treating equine joint disease Open
OBJECTIVE To establish the pharmacokinetics of the cyclin-dependent kinase-9 inhibitor flavopiridol in equine middle carpal joints, using an extended-release poly lactic- co -glycolic acid (PLGA) microparticle formulation. ANIMALS 4 health…
View article: Effect of clodronate on gene expression in the peripheral blood of horses
Effect of clodronate on gene expression in the peripheral blood of horses Open
There are two FDA‐approved bisphosphonate products, clodronate (Osphos®) and tiludronate (Tildren®), for use in horses. It is hypothesized that bisphosphonates can produce analgesic effects and prevent proper healing of microcracks in bone…
View article: Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block
Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block Open
Background Lidocaine is a local anesthetic that is sometimes administered in combination with epinephrine. The addition of epinephrine increases the time lidocaine remains at the site of administration, thus prolonging the duration of effe…
View article: Comparison of <sup>18</sup> F‐sodium fluoride positron emission tomography and computed tomography for imaging of the fetlock in 25 nonracehorses
Comparison of <sup>18</sup> F‐sodium fluoride positron emission tomography and computed tomography for imaging of the fetlock in 25 nonracehorses Open
Background 18 F‐sodium fluoride ( 18 F‐NaF) positron emission tomography (PET) has been validated as a useful imaging technique in the racehorse fetlock. The use of 18 F‐NaF PET in the nonracehorse fetlock has not been reported. Objectives…
View article: 18F-sodium fluoride positron emission tomography provides pertinent additional information to computed tomography for assessment and management of tarsal pain in horses
18F-sodium fluoride positron emission tomography provides pertinent additional information to computed tomography for assessment and management of tarsal pain in horses Open
OBJECTIVE To assess the value of 18 F-sodium fluoride ( 18 F-NaF) positron emission tomography (PET) for imaging the tarsus and proximal metatarsus and compare it with CT and lameness evaluation. ANIMALS 25 horses with lameness localized t…
View article: Septic inflammation of the bicipital bursa: clinical, imaging, and surgical findings in nine horses
Septic inflammation of the bicipital bursa: clinical, imaging, and surgical findings in nine horses Open
OBJECTIVE To describe the etiologies, clinicopathologic findings, diagnostic modalities employed, treatments, and outcome associated with cases of septic bicipital bursitis. ANIMALS 9 horses. CLINICAL PRESENTATION AND PROCEDURES Medical re…
View article: Issue Information
Issue Information Open
From Voges et al. 3D reformatted CT images used to assess effects of 3D study materials on 1 st and 2 nd year DVM student performance in interpreting abdominal radiographs.Students could manipulate the slices using a pen tool (Echopixel, h…
View article: Examining the Effects of In Vitro Co-Culture of Equine Adipose-Derived Mesenchymal Stem Cells With Tendon Proper and Peritenon Cells
Examining the Effects of In Vitro Co-Culture of Equine Adipose-Derived Mesenchymal Stem Cells With Tendon Proper and Peritenon Cells Open
Tendinopathies remain the leading contributor to career-ending injuries in horses because of the complexity of tendon repair. As such, cell-based therapies like injections of adipose-derived mesenchymal stem cells (ADMSCs, or MSCs) into in…
View article: Identification of putative orthologs of clinically relevant antimicrobial peptides in the equine ocular surface and amniotic membrane
Identification of putative orthologs of clinically relevant antimicrobial peptides in the equine ocular surface and amniotic membrane Open
Objectives This study aimed to define the antimicrobial peptide (AMP) expression pattern of the equine ocular surface and amniotic membrane using a targeted qPCR approach and 3'Tag‐sequencing. It will serve as a reference for future studie…
View article: Increased α‐tocopherol metabolism in horses with equine neuroaxonal dystrophy
Increased α‐tocopherol metabolism in horses with equine neuroaxonal dystrophy Open
Background Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is an inherited neurodegenerative disorder associated with a vitamin E deficiency within the first year of life. Vitamin E consists of 8 isoforms me…
View article: <sup>18</sup>Fluorine‐fluorodeoxyglucose positron emission tomography for assessment of deep digital flexor tendinopathy: An exploratory study in eight horses with comparison to CT and MRI
<sup>18</sup>Fluorine‐fluorodeoxyglucose positron emission tomography for assessment of deep digital flexor tendinopathy: An exploratory study in eight horses with comparison to CT and MRI Open
Lesions of the deep digital flexor tendon (DDFT) are a cause for foot lameness in horses. Positron emission tomography (PET) could provide valuable information regarding the metabolic activity of these lesions. The aims of this exploratory…
View article: Postmortem diagnoses of spinal ataxia in 316 horses in California
Postmortem diagnoses of spinal ataxia in 316 horses in California Open
OBJECTIVE To determine period prevalences of postmortem diagnoses for spinal cord or vertebral column lesions as underlying causes of ataxia (spinal ataxia) in horses. ANIMALS 2,861 client-owned horses (316 with ataxia [ataxic group] and 2…
View article: Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative
Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative Open
Following the successful creation of a biobank from two adult Thoroughbred mares, this study aimed to recapitulate sample collection in two adult Thoroughbred stallions as part of the Functional Annotation of the Animal Genome (FAANG) init…
View article: Incidence of incisional complications after exploratory celiotomy in equids affected with enterolithiasis.
Incidence of incisional complications after exploratory celiotomy in equids affected with enterolithiasis. Open
This study reports the prevalence of and risk factors for incisional complications in equids after ventral midline celiotomy for enterolithiasis. This study covered the years 2008 to 2015 and included 72 equids. Enteroliths were removed fr…
View article: Safety and efficacy of subcutaneous alpha‐tocopherol in healthy adult horses
Safety and efficacy of subcutaneous alpha‐tocopherol in healthy adult horses Open
Summary Vitamin E is essential for neuromuscular function. The primary treatment, oral supplementation with natural (‘RRR’) α‐tocopherol, is not effective in all horses. The objectives of this pilot study were to evaluate the safety and ef…
View article: Chondrosesamoidean ligament enthesopathy: Prevalence and findings in a population of lame horses imaged with positron emission tomography
Chondrosesamoidean ligament enthesopathy: Prevalence and findings in a population of lame horses imaged with positron emission tomography Open
Background Increased 18 F‐Sodium Fluoride ( 18 F‐NaF) uptake at the chondrosesamoidean ligament (ChSL) attachment on the distal phalanx was identified in an exploratory positron emission tomography (PET) study. The prevalence and significa…
View article: 3 Dimensional photonic scans for measuring body volume and muscle mass in the standing horse
3 Dimensional photonic scans for measuring body volume and muscle mass in the standing horse Open
The hand-held 3D scan provided a rapid repeatable assessment of torso and hindquarter volume strongly correlated to body weight and estimated volume. Superimposition of regional scans and volume measures could provide a practical means to …
View article: Impact of alpha‐tocopherol deficiency and supplementation on sacrocaudalis and gluteal muscle fiber histopathology and morphology in horses
Impact of alpha‐tocopherol deficiency and supplementation on sacrocaudalis and gluteal muscle fiber histopathology and morphology in horses Open
Background A subset of horses deficient in alpha‐tocopherol (α‐TP) develop muscle atrophy and vitamin E‐responsive myopathy (VEM) characterized by mitochondrial alterations in the sacrocaudalis dorsalis medialis muscle (SC). Objectives To …
View article: Pathological Safety Assessment in Preclinical Neurothrombectomy Studies
Pathological Safety Assessment in Preclinical Neurothrombectomy Studies Open
The design, production, and preclinical testing of neurothrombectomy devices is in a burgeoning phase as the demand escalates for safe and reliable treatment options following neurovascular stroke. Currently, there is a paucity of publishe…
View article: Generation of an equine biobank to be used for Functional Annotation of Animal Genomes project
Generation of an equine biobank to be used for Functional Annotation of Animal Genomes project Open
Summary The Functional Annotation of Animal Genomes ( FAANG ) project aims to identify genomic regulatory elements in both sexes across multiple stages of development in domesticated animals. This study represents the first stage of the FA…
View article: <sup>18</sup> F‐sodium fluoride positron emission tomography of the racing Thoroughbred fetlock: Validation and comparison with other imaging modalities in nine horses
<sup>18</sup> F‐sodium fluoride positron emission tomography of the racing Thoroughbred fetlock: Validation and comparison with other imaging modalities in nine horses Open
Summary Background Early and accurate detection of stress remodelling in racehorses is of utmost importance to prevent catastrophic injuries. Current imaging techniques have limitations in assessing early changes predisposing to catastroph…
View article: Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy
Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy Open
Background Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α‐tocopherol (α‐TOH) deficient diet. Currently no antemorte…
View article: Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis
Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis Open
Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development o…
View article: <sup>18</sup> F‐sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses
<sup>18</sup> F‐sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses Open
Summary Background Positron emission tomography (PET) is a cross‐sectional, functional imaging modality that has recently become available to the horse. The use of 18 F‐sodium fluoride ( 18 F‐NaF), a PET bone tracer, has not previously bee…
View article: Blood and Cerebrospinal Fluid α‐Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophy
Blood and Cerebrospinal Fluid α‐Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophy Open
Background Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy ( NAD / EDM ) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α‐tocopherol (α‐ TP )‐deficient diet. Objective Intramuscul…