Scott A. Mosley
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View article: Impact of resident teaching mentors on teaching certificate program outcomes
Impact of resident teaching mentors on teaching certificate program outcomes Open
Purpose USC Mann has a longstanding and robust teaching certificate program involving 30 to 37 residents in USC and USC-affiliated residency programs annually. In 2020, resident teaching mentors (RTMs) were added to the program. Residents …
View article: Identifying Opioid-Related Pharmacogenomic Variants in High-Risk Hospitalized Infants: A Pilot Study
Identifying Opioid-Related Pharmacogenomic Variants in High-Risk Hospitalized Infants: A Pilot Study Open
Introduction Pharmacogenomic (PGx) variants impact the pharmacodynamics and pharmacokinetics of opioids and the brain’s reward, cognition, stress, and pain pathways. This study examines the prevalence of PGx variants impacting opioid respo…
View article: Decoding pharmacogenomic test interpretation and application to patient care
Decoding pharmacogenomic test interpretation and application to patient care Open
Pharmacogenomics is a growing area of medicine, and pharmacists across clinical practice settings have the opportunity to individualize medication selection and dosing using genetic data. However, many practicing pharmacists may feel ill‐e…
View article: <scp> <i>CYP2D6</i> </scp> ‐guided opioid therapy for adults with cancer pain: A randomized implementation clinical trial
<span> <i>CYP2D6</i> </span> ‐guided opioid therapy for adults with cancer pain: A randomized implementation clinical trial Open
Introduction The CYP2D6 enzyme metabolizes opioids commonly prescribed for cancer‐related pain, and CYP2D6 polymorphisms may contribute to variability in opioid response. We evaluated the feasibility of implementing CYP2D6 ‐guided opioid p…
View article: Medication reconciliation to support pharmacogenomics implementation
Medication reconciliation to support pharmacogenomics implementation Open
Petry et al.(1) reported on the first large-scale study quantifying and classifying the impact of using medication reconciliation (med rec) to support the implementation of pharmacogenomics (PGx) test results into clinical care within a he…
View article: A randomized, cross‐over trial of metoprolol succinate formulations to evaluate <scp>PK</scp> and <scp>PD</scp> end points for therapeutic equivalence
A randomized, cross‐over trial of metoprolol succinate formulations to evaluate <span>PK</span> and <span>PD</span> end points for therapeutic equivalence Open
There are limited comparison data throughout the dosing interval for generic versus brand metoprolol extended‐release (ER) tablets. We compared the pharmacokinetics (PKs) and pharmacodynamics of brand name versus two generic formulations (…
View article: Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across <i>CYP2D6</i> Genotype‐Derived Activity Scores
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across <i>CYP2D6</i> Genotype‐Derived Activity Scores Open
Recent CYP2D6 phenotype standardization efforts by CYP2D6 activity score (AS) are based on limited pharmacokinetic (PK) and pharmacodynamic (PD) data. Using data from two independent clinical trials of metoprolol, we compared metoprolol PK…
View article: 4061 Clinical utility of precision medicine approaches to guide anti-platelet selection for adult patients with acute coronary syndromes (ACS), following percutaneous coronary intervention (PCI)
4061 Clinical utility of precision medicine approaches to guide anti-platelet selection for adult patients with acute coronary syndromes (ACS), following percutaneous coronary intervention (PCI) Open
OBJECTIVES/GOALS: Our goal is to determine if a precision medicine approach to guide anti-platelet therapy for patients with ACS, post PCI, is feasible for a diverse urban population. Also, we will evaluate if guided therapy reduces major …
View article: Institutional Profile: University of Florida Health Personalized Medicine Program
Institutional Profile: University of Florida Health Personalized Medicine Program Open
The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with CYP2C19 genotyping for clopidogrel response at UF Health Shands Hospital. We have since expanded CYP2C19 genotyping to UF Health Jacksonville and est…
View article: Evaluation of the impact of treatment delays and dose reductions in human ovarian cancer orthotopic mouse models
Evaluation of the impact of treatment delays and dose reductions in human ovarian cancer orthotopic mouse models Open
The primary objective of this study was to quantify the impact of treatment delay and dose reductions in an in vivo orthotopic ovarian cancer model. In addition, this study evaluated the role of growth factors in achieving “full dose on ti…