Scott A. Rodeo
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View article: Platelet-Poor Plasma for Muscle Injuries: A Review of Mechanisms and Clinical Perspectives
Platelet-Poor Plasma for Muscle Injuries: A Review of Mechanisms and Clinical Perspectives Open
Background: Muscle injuries are a frequent challenge in professional sports, with hamstring injuries being particularly prevalent. Despite advances in rehabilitation protocols, recurrence rates remain high, and recovery timelines vary depe…
View article: Regenerative Medicine: Tremendous Potential but Not Quite Ready for Prime-Time
Regenerative Medicine: Tremendous Potential but Not Quite Ready for Prime-Time Open
This guest editorial gives an overview of the field of regenerative medicine and the special issue.
View article: Mouse Model for Combined Oral Contraceptive Administration in Diet
Mouse Model for Combined Oral Contraceptive Administration in Diet Open
BACKGROUND: Combined oral contraceptives (COCs), containing synthetic estrogen and progestin, are widely used for birth control and managing various conditions. A wide variety of COC formulations are prescribed, yet formulation-specific ef…
View article: Poster 234: Improvement of Tendon-Bone Interface Healing by Moderate Treadmill Exercise Combined with Knee Brace Immobilization Following an Anterior Cruciate Ligament Reconstruction in a Murine Model
Poster 234: Improvement of Tendon-Bone Interface Healing by Moderate Treadmill Exercise Combined with Knee Brace Immobilization Following an Anterior Cruciate Ligament Reconstruction in a Murine Model Open
Objectives: Recent studies have been using the anterior cruciate ligament reconstruction (ACLR) mouse model to study the tendon-bone interface (TBI) healing process and the development of post-traumatic osteoarthritis. Our prior research i…
View article: Poster 194: Early Anterior Cruciate Ligament Reconstruction Mitigates the Development of Post-Traumatic Osteoarthritis in a Murine Non-Invasive Anterior Cruciate Ligament Rupture Model
Poster 194: Early Anterior Cruciate Ligament Reconstruction Mitigates the Development of Post-Traumatic Osteoarthritis in a Murine Non-Invasive Anterior Cruciate Ligament Rupture Model Open
Objectives: The primary aim of the present study is to evaluate the impact of timing of ACLR on the development of PTOA using a murine non-surgical (“closed”) ACL rupture model. The secondary aim is to evaluate the impact of the timing of …
View article: Poster 51: Platelet Concentration Factor Explains Variability in Outcomes of Platelet-Rich Plasma for Lateral Epicondylitis - High Dose Critical for Positive Response
Poster 51: Platelet Concentration Factor Explains Variability in Outcomes of Platelet-Rich Plasma for Lateral Epicondylitis - High Dose Critical for Positive Response Open
Objectives: Randomized controlled trials (RCTs) evaluating the efficacy of platelet-rich plasma (PRP) for the management of lateral epicondylitis (LE) have been characterized by substantial variability in reported outcomes. The source of t…
View article: Paper 06: Immunologic Response of Non-Matched Osteochondral Allografts: A Prospective Study with One-Year Follow-up
Paper 06: Immunologic Response of Non-Matched Osteochondral Allografts: A Prospective Study with One-Year Follow-up Open
Objectives: Fresh osteochondral allograft transplantation (OCA) is commonly used to treat large articular chondral or osteochondral defects, especially in younger patients, because it allows for delivery of mature, viable hyaline cartilage…
View article: Corrigendum to “The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial” [Osteoarthr Cartil Open 7 (2025) 100563]
Corrigendum to “The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial” [Osteoarthr Cartil Open 7 (2025) 100563] Open
View article: Evaluation of the Effect of Tranexamic Acid on Meniscus Healing and Articular Cartilage in a Rabbit Model
Evaluation of the Effect of Tranexamic Acid on Meniscus Healing and Articular Cartilage in a Rabbit Model Open
Background: The formation of a stable fibrin clot plays an important role in early tissue repair. Tranexamic acid (TXA), a potent fibrinolysis inhibitor, prevents fibrin clot dissolution. Purpose: We sought to test the effect of intra-arti…
View article: Pathologic profibrotic activation of distinct myeloid cell subsets in a model of impaired healing after anterior cruciate ligament reconstruction
Pathologic profibrotic activation of distinct myeloid cell subsets in a model of impaired healing after anterior cruciate ligament reconstruction Open
Anterior cruciate ligament reconstruction (ACLR) may fail due to poor bone-to-tendon integration, yet the cellular mechanisms underlying this process remain incompletely understood. Using a murine model of ACLR, we show that host-derived i…
View article: Development of Explainable Machine Learning Models to Predict Outcomes After Platelet-Rich Plasma Injections for Knee Osteoarthritis
Development of Explainable Machine Learning Models to Predict Outcomes After Platelet-Rich Plasma Injections for Knee Osteoarthritis Open
Background: Platelet-rich plasma (PRP) has been increasingly used to treat knee osteoarthritis, but its efficacy remains unclear due to the variability of outcomes. Machine learning (ML) can improve the ability to predict responses to PRP …
View article: The Hospital for Special Surgery Center for Regenerative Medicine: Clinical Registries, Basic and Translational Research, and Education Programs
The Hospital for Special Surgery Center for Regenerative Medicine: Clinical Registries, Basic and Translational Research, and Education Programs Open
View article: Management of posterior cruciate ligament injuries: an expert consensus from 17 countries
Management of posterior cruciate ligament injuries: an expert consensus from 17 countries Open
Background: Posterior cruciate ligament (PCL) injury is a relatively common musculoskeletal condition. However, there is currently a lack of consensus on decision-making, treatment and postoperative management for such injuries. Objectives…
View article: Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury
Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury Open
Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To …
View article: Feasibility of subantimicrobial-dose doxycycline for elbow tendinopathy
Feasibility of subantimicrobial-dose doxycycline for elbow tendinopathy Open
View article: In Pursuit of Quantifying Patient Knee Contact Mechanics: Finite Element Model Validation of Cadaveric Knees in Axially Loaded MRI Scans
In Pursuit of Quantifying Patient Knee Contact Mechanics: Finite Element Model Validation of Cadaveric Knees in Axially Loaded MRI Scans Open
Our long‐term objective is to quantify patient‐specific changes in contact mechanics after partial meniscectomy (PM) using knee‐specific finite element (FE) models created from clinical MR scans under axial load. Before creating patient‐sp…
View article: Remodeling Process of the Tendon Graft After Anterior Cruciate Ligament Reconstruction: Comprehensive Analysis With RNA Sequencing in a Murine Model
Remodeling Process of the Tendon Graft After Anterior Cruciate Ligament Reconstruction: Comprehensive Analysis With RNA Sequencing in a Murine Model Open
The tendon graft is known to undergo a remodeling process after anterior cruciate ligament (ACL) reconstruction. However, little is known about the transcriptional profile of this process. The aim of the present study is to identify differ…
View article: Novel Noninvasive Imaging Techniques to Assess Structural, Functional, and Material Properties of Tendon, Ligament, and Cartilage: A Narrative Review of Current Concepts
Novel Noninvasive Imaging Techniques to Assess Structural, Functional, and Material Properties of Tendon, Ligament, and Cartilage: A Narrative Review of Current Concepts Open
Background: Novel noninvasive imaging modalities such as quantitative magnetic resonance imaging (qMRI) and shear wave elastography (SWE) allow for assessment of soft tissue microstructure and composition, which ultimately may be associate…
View article: The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial
The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial Open
clinicaltrials.gov NCT06096259.
View article: Return to Sport in Professional Athletes After Cartilage Restoration Surgery of the Knee: A Systematic Review and Meta-Analysis Demonstrates Gender Inequality and the Need for Improved Reporting
Return to Sport in Professional Athletes After Cartilage Restoration Surgery of the Knee: A Systematic Review and Meta-Analysis Demonstrates Gender Inequality and the Need for Improved Reporting Open
Objective To synthesize the literature concerning return to sport (RTS) and related outcomes after cartilage restoration surgery of the knee in professional athletes. Design Cochrane, PubMed, and OVID/Medline databases were queried for dat…
View article: Efficacy and safety of xenograft augmentation in rotator cuff repair: a systematic review and meta-analysis
Efficacy and safety of xenograft augmentation in rotator cuff repair: a systematic review and meta-analysis Open
Rotator cuff tears are common disorders that can significantly impact patientś shoulder function and quality of life. Incomplete or failed healing is relatively common following repair of large tendon tears. Xenograft materials are increas…
View article: Outcomes of orthopaedic surgery in Ehlers-Danlos syndromes: a scoping review
Outcomes of orthopaedic surgery in Ehlers-Danlos syndromes: a scoping review Open
View article: An ultrastructure analysis of the developing human anterior cruciate ligament tibial enthesis
An ultrastructure analysis of the developing human anterior cruciate ligament tibial enthesis Open
This study aimed to investigate the ultrastructural anatomy of the developing ACL tibial enthesis. We hypothesized that enthesis architecture would progressively mature and remodel, eventually resembling that of the adult by the early post…
View article: Defining clinically relevant outcome thresholds for pain and function after osteochondral autograft transplantation of the knee
Defining clinically relevant outcome thresholds for pain and function after osteochondral autograft transplantation of the knee Open
Purpose To define the minimal clinically important difference (MCID) for measures of pain and function at 2, 5 and 10 years after osteochondral autograft transplantations (OATs). Methods Patients undergoing OATs of the knee were identified…
View article: Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseases
Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseases Open
The transition of fibroblasts to myofibroblasts (FMT) represents a pivotal process in wound healing, tissue repair, and fibrotic diseases. This intricate transformation involves dynamic changes in cellular morphology, gene expression, and …
View article: Poster 352: Histopathological Etiology of Mucoid Degeneration of the Anterior Cruciate Ligament
Poster 352: Histopathological Etiology of Mucoid Degeneration of the Anterior Cruciate Ligament Open
Objectives: Mucoid degeneration of the anterior cruciate ligament (ACL) is an uncommon clinical condition with reported prevalence below 0.5%. There is a paucity of histopathological description in the literature, which has limited our und…
View article: Poster 364: Tendon-Bone Interface Healing Improvement by Moderate Treadmill Exercise Following an Anterior Cruciate Ligament Reconstruction in a Murine Model
Poster 364: Tendon-Bone Interface Healing Improvement by Moderate Treadmill Exercise Following an Anterior Cruciate Ligament Reconstruction in a Murine Model Open
Objectives: Recent studies have been using the anterior cruciate ligament reconstruction (ACLR) mouse model to study the tendon-bone healing process and the development of post-traumatic osteoarthritis. While it is known that mechanical lo…
View article: Meniscus Tears in Elite Athletes: Treatment Considerations, Clinical Outcomes, and Return to Play
Meniscus Tears in Elite Athletes: Treatment Considerations, Clinical Outcomes, and Return to Play Open
View article: Nothing Heals Without Cells
Nothing Heals Without Cells Open
View article: Rehabilitation and return-to-play following knee cartilage injuries-an international Delphi consensus statement
Rehabilitation and return-to-play following knee cartilage injuries-an international Delphi consensus statement Open
Introduction: Articular cartilage injuries of the knee are a complex and challenging clinical pathology. Objectives: The purpose of this study was to establish consensus statements via a Delphi process on rehabilitation and return to play …