Stuart A. Rice
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View article: Prediction of symptomatic and asymptomatic bacteriuria in spinal cord injury patients using machine learning
Prediction of symptomatic and asymptomatic bacteriuria in spinal cord injury patients using machine learning Open
Background Individuals with spinal cord injuries (SCI) frequently rely on urinary catheters to drain urine from the bladder, making them susceptible to asymptomatic and symptomatic catheter-associated bacteriuria and urinary tract infectio…
View article: A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients
A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients Open
Complex multispecies biofilms consistently colonise urinary catheters, causing persistent asymptomatic bacteriuria and frequent symptomatic episodes in long-term catheterized individuals. Simple single-species models often fail to capture …
View article: Rhodium-catalysed connective synthesis of diverse reactive probes bearing S(VI) electrophilic warheads
Rhodium-catalysed connective synthesis of diverse reactive probes bearing S(VI) electrophilic warheads Open
The value of small molecules that chemically modify proteins is increasingly being recognised and utilised in both chemical biology and drug discovery. The discovery of such chemical tools may be enabled by screening diverse sets of reacti…
View article: Genome-scale metabolic modelling of human gut microbes to inform rational community design
Genome-scale metabolic modelling of human gut microbes to inform rational community design Open
The human gut microbiome impacts host health through metabolite production, notably short-chain fatty acids (SCFAs) derived from digestion-resistant carbohydrates (DRCs). While DRC supplementation offers a means to modulate the microbiome …
View article: Alginate exopolymer significantly modulates the viscoelastic properties and resilience of bacterial biofilms
Alginate exopolymer significantly modulates the viscoelastic properties and resilience of bacterial biofilms Open
Biofilms are viscoelastic gels with a cross-linked network of biopolymers forming an extracellular matrix that protects bacteria from most antimicrobial treatments. This study examines the physical role of the matrix in preventing recoloni…
View article: A REVIEW ON DISTINGUISHING CHARACTERISTICS OF INDIGENOUS CATTLE BREEDS OF INDIA
A REVIEW ON DISTINGUISHING CHARACTERISTICS OF INDIGENOUS CATTLE BREEDS OF INDIA Open
This review explores India’s indigenous bovine breeds, highlighting their genetic diversity, economic importance, and resilience to tropical diseases and harsh climates. These breeds play a vital role in rural economies by providing milk, …
View article: Potential confounding mutations in Keio knockout strains: implications for research accuracy
Potential confounding mutations in Keio knockout strains: implications for research accuracy Open
The Keio library of single-gene knock-out mutants of Escherichia coli is useful for the research community. It has been used to analyze the role of various E. coli genes in alcohol tolerance, multi-drug resistance, and biofilm formation. T…
View article: Transcriptional signatures associated with the survival of Escherichia coli biofilm during treatment with plasma-activated water
Transcriptional signatures associated with the survival of Escherichia coli biofilm during treatment with plasma-activated water Open
Biofilm formation on surfaces, tools and equipment can damage their quality and lead to high repair or replacement costs. Plasma-activated water (PAW), a new technology, has shown promise in killing biofilm and non-biofilm bacteria due to …
View article: Non-Emergency Medical Transportation for Vulnerable Aging Residents of Iosco County, Michigan
Non-Emergency Medical Transportation for Vulnerable Aging Residents of Iosco County, Michigan Open
The Rural Health Group and the Iosco County Commission on Aging, in Michigan, conducted a comprehensive investigation of the needs of t home-delivered meal recipients for transportation access to medical and healthcare utilization.* This p…
View article: A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients
A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients Open
Complex multispecies biofilms consistently colonise the interior of indwelling urinary catheters, causing persistent asymptomatic bacteriuria and frequent symptomatic episodes in long-term catheterized individuals. Simple single-species mo…
View article: Towards integrated cross-sectoral surveillance of pathogens and antimicrobial resistance: Needs, approaches, and considerations for linking surveillance to action
Towards integrated cross-sectoral surveillance of pathogens and antimicrobial resistance: Needs, approaches, and considerations for linking surveillance to action Open
Pathogenic and antimicrobial-resistant (AMR) microorganisms are continually transmitted between human, animal, and environmental reservoirs, contributing to the high burden of infectious disease and driving the growing global AMR crisis. T…
View article: Prediction of symptomatic and asymptomatic bacteriuria in spinal cord injury patients using machine learning
Prediction of symptomatic and asymptomatic bacteriuria in spinal cord injury patients using machine learning Open
Background Individuals with spinal cord injuries (SCI) frequently rely on urinary catheters to drain urine from the bladder, making them susceptible to asymptomatic and symptomatic catheter-associated bacteriuria and urinary tract infectio…
View article: Antimicrobial mechanism of<i>in-situ</i>plasma activated water treatment of pathogenic<i>Escherichia coli</i>and<i>Staphylococcus aureus</i>biofilms
Antimicrobial mechanism of<i>in-situ</i>plasma activated water treatment of pathogenic<i>Escherichia coli</i>and<i>Staphylococcus aureus</i>biofilms Open
Aims This study investigated the efficacy and mechanisms of inactivation of against Escherichia coli UTI89 and Staphylococcus aureus NCTC8325 through an in-situ plasma-activated water (PAW) treatment. Methods and Results PAW was prepared b…
View article: Genome scale metabolic modelling of human gut microbes to inform rational community design
Genome scale metabolic modelling of human gut microbes to inform rational community design Open
The human gut microbiome impacts host health through metabolite production, notably short-chain fatty acids (SCFAs) derived from digestion-resistant carbohydrates (DRCs). While DRC supplementation offers a means to modulate the microbiome …
View article: Transcriptional Signatures Associated with the Survival of<i>Escherichia coli</i>Biofilm During Treatment with Plasma-Activated Water
Transcriptional Signatures Associated with the Survival of<i>Escherichia coli</i>Biofilm During Treatment with Plasma-Activated Water Open
Biofilm formation on surfaces, tools and equipment can damage their quality and lead to high repair or replacement costs. Plasma-activated water (PAW), a new technology, has shown promise in killing biofilm and non-biofilm bacteria due to …
View article: Decoding scalp health and microbiome dysbiosis in dandruff
Decoding scalp health and microbiome dysbiosis in dandruff Open
A balanced scalp microbiome is crucial for scalp health, yet the mechanisms governing this balance and the etiology of dysbiosis in scalp disorders remain elusive. We conducted a detailed investigation of the scalp and hair follicles, in h…
View article: Microbial Indoles: Key Regulators of Organ Growth and Metabolic Function
Microbial Indoles: Key Regulators of Organ Growth and Metabolic Function Open
Gut microbes supporting body growth are known but the mechanisms are less well documented. Using the microbial tryptophan metabolite indole, known to regulate prokaryotic cell division and metabolic stress conditions, we mono-colonized ger…
View article: Life at the borderlands: microbiomes of interfaces critical to One Health
Life at the borderlands: microbiomes of interfaces critical to One Health Open
Microbiomes are foundational components of the environment that provide essential services relating to food security, carbon sequestration, human health, and the overall well-being of ecosystems. Microbiota exert their effects primarily th…
View article: The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture
The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture Open
Bacterial lifestyles depend on conditions encountered during colonization. The transition between planktonic and biofilm growth is dependent on the intracellular second messenger c-di-GMP. High c-di-GMP levels driven by diguanylate cyclase…
View article: Multispecies bacterial invasion of human host cells
Multispecies bacterial invasion of human host cells Open
Urinary tract infection (UTI), one of the most common bacterial infections worldwide, is a typical example of an infection that is often polymicrobial in nature. While the overall infection course is known on a macroscale, bacterial behavi…
View article: GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876
GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876 Open
The Mycobacterium tuberculosis ( Mtb ) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and dis…
View article: Single cell RNA-seq reveals that the Vibrio cholerae MakA toxin is required for killing of Tetrahymena pyriformis and for survival in protozoan expelled food vacuoles
Single cell RNA-seq reveals that the Vibrio cholerae MakA toxin is required for killing of Tetrahymena pyriformis and for survival in protozoan expelled food vacuoles Open
Vibrio cholerae uses multiple strategies to resist predation by heterotrophic protozoa. For example, V. cholerae releases toxic compounds such as ammonium and pyomelanin, that can kill protists such as Tetrahymena pyriformis. V. cholerae a…
View article: Increased iron utilization and oxidative stress tolerance in a <i>Vibrio cholerae flrA</i> mutant confers resistance to amoeba predation
Increased iron utilization and oxidative stress tolerance in a <i>Vibrio cholerae flrA</i> mutant confers resistance to amoeba predation Open
The flagellar transcriptional regulator flrA initiates the regulatory cascade of flagellum synthesis in Vibrio cholerae . Previously, we observed an increase in sub-populations of V. cholerae carrying mutations in the flrA gene during long…
View article: Plasma activated water as a pre-treatment strategy in the context of biofilm-infected chronic wounds
Plasma activated water as a pre-treatment strategy in the context of biofilm-infected chronic wounds Open
Healing and treatment of chronic wounds are often complicated due to biofilm formation by pathogens. Here, the efficacy of plasma activated water (PAW) as a pre-treatment strategy has been investigated prior to the application of topical a…