Scott B. Halstead
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View article: Post COVID glaucoma service redesign utilising electronic patient triage and community optometry clinics (Fife, Scotland 2020—2022)
Post COVID glaucoma service redesign utilising electronic patient triage and community optometry clinics (Fife, Scotland 2020—2022) Open
Glaucoma patients in Scotland can be appropriately triaged to glaucoma accredited community optometry clinics. This frees capacity within hospital to see patients with moderate and severe disease in a timely fashion, for best visual outcom…
View article: Delivering safe dengue vaccines
Delivering safe dengue vaccines Open
View article: Dengue NS1 Antibodies Are Associated With Clearance of Viral Nonstructural Protein-1
Dengue NS1 Antibodies Are Associated With Clearance of Viral Nonstructural Protein-1 Open
Background Dengue vascular permeability syndrome is the primary cause of death in severe dengue infections. The protective versus potentially pathogenic role of dengue nonstructural protein-1 (NS1) antibodies are not well understood. The m…
View article: Alterations in peripheral levels of cytokines and associated inflammatory markers in acute and chronic stages of schizophrenia spectrum disorders: a systematic review and network meta-analysis
Alterations in peripheral levels of cytokines and associated inflammatory markers in acute and chronic stages of schizophrenia spectrum disorders: a systematic review and network meta-analysis Open
Introduction It has been previously identified that levels of peripheral inflammatory proteins, such as cytokines, are altered in people with schizophrenia spectrum disorders (SSD). Objectives As there is considerable inconsistency in the …
View article: Comments on “Dengue management in triage using ultrasound in children from Cambodia: A prospective cohort study”
Comments on “Dengue management in triage using ultrasound in children from Cambodia: A prospective cohort study” Open
View article: Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development
Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development Open
View article: Human factors in emerging infectious diseases
Human factors in emerging infectious diseases Open
When the underlying causes and mechanisms of emerging infectious disease problems are studied carefully, human behaviour is often involved. Even more often, the only methods of control or prevention available are to change human behaviour.…
View article: Correction: In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection
Correction: In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection Open
Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection. Affected individuals also generate cross-reactive antibodies against heterol…
View article: Major General (Ret) Philip King Russell
Major General (Ret) Philip King Russell Open
View article: Preparing for the Behavioral Health Impact of COVID-19 in Michigan
Preparing for the Behavioral Health Impact of COVID-19 in Michigan Open
View article: COVID-19 Vaccines: Should We Fear ADE?
COVID-19 Vaccines: Should We Fear ADE? Open
Might COVID-19 vaccines sensitize humans to antibody-dependent enhanced (ADE) breakthrough infections? This is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological, or pathological attributes of AD…
View article: Ethics of a partially effective dengue vaccine: Lessons from the Philippines
Ethics of a partially effective dengue vaccine: Lessons from the Philippines Open
View article: COVID-19 and SARS Coronavirus 2: Antibodies for the Immediate Rescue and Recovery Phase
COVID-19 and SARS Coronavirus 2: Antibodies for the Immediate Rescue and Recovery Phase Open
OPINION article Front. Immunol., 29 May 2020Sec. Vaccines and Molecular Therapeutics Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.01196
View article: An Urgent Need for “Common Cold Units” to Study COVID-19
An Urgent Need for “Common Cold Units” to Study COVID-19 Open
View article: COVID-19: The Need for Immunoprevention at Industrial Scale
COVID-19: The Need for Immunoprevention at Industrial Scale Open
Severe acute respiratory syndrome-CoV-2 infections are exacting devastating mortality in elderly persons with preexisting health conditions.This has led to widespread quarantining, suspension of social and business activities, frightening …
View article: Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries
Genetic risk for dengue hemorrhagic fever and dengue fever in multiple ancestries Open
There is a strong genetic effect that predisposes to risk of DHF/DSS and DF. The genetic risk for DHF/DSS is higher than that for DF when compared to controls, and this effect persists across multiple ancestries.
View article: Recent advances in understanding dengue
Recent advances in understanding dengue Open
This is a selective review of recent publications on dengue clinical features, epidemiology, pathogenesis, and vaccine development placed in a context of observations made over the past half century. Four dengue viruses (DENVs) are transmi…
View article: Faculty Opinions recommendation of OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans.
Faculty Opinions recommendation of OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans. Open
Ethnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective …
View article: Faculty Opinions recommendation of Contributions from the silent majority dominate dengue virus transmission.
Faculty Opinions recommendation of Contributions from the silent majority dominate dengue virus transmission. Open
Despite estimates that, each year, as many as 300 million dengue virus (DENV) infections result in either no perceptible symptoms (asymptomatic) or symptoms that are sufficiently mild to go undetected by surveillance systems (inapparent), …
View article: Faculty Opinions recommendation of Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism.
Faculty Opinions recommendation of Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism. Open
Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans. The flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein involved in viral replication, immune evasion, and vascular leakage during dengue virus in…
View article: Faculty Opinions recommendation of Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas.
Faculty Opinions recommendation of Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas. Open
BACKGROUND: Dengue is a major public health problem worldwide. Assessment of adaptive immunity is important to understanding immunopathology and to define correlates of protection against dengue virus (DENV). To enable global assessment of…
View article: NS1, Dengue’s Dagger
NS1, Dengue’s Dagger Open
View article: Japanese encephalitis vaccine for travelers: risk-benefit reconsidered
Japanese encephalitis vaccine for travelers: risk-benefit reconsidered Open
View article: Referee report. For: Considerations for the 2030 Sustainable Development Goals for dengue [version 1; peer review: 1 approved with reservations]
Referee report. For: Considerations for the 2030 Sustainable Development Goals for dengue [version 1; peer review: 1 approved with reservations] Open
View article: Insights from direct studies on human dengue infections
Insights from direct studies on human dengue infections Open
A close look at dengue viremia in humans resulted in a discovery that has rocked the dengue world. In PNAS, Raut et al. (1) cleverly manipulated viruses recovered from the blood of acute dengue virus type 1 (DENV1) infections and show that…
View article: Cause and consequence of loss in vaccine trust
Cause and consequence of loss in vaccine trust Open
Dear Editor,This letter is written in response to an article by Larson et al entitled “Vaccine confidence plummets in the Philippines following dengue vaccine scare: why it matters to pandemic prep...
View article: Nguyen Trong Lan, MD, PhD
Nguyen Trong Lan, MD, PhD Open
View article: Safety issues from a Phase 3 clinical trial of a live-attenuated chimeric yellow fever tetravalent dengue vaccine
Safety issues from a Phase 3 clinical trial of a live-attenuated chimeric yellow fever tetravalent dengue vaccine Open
A tetravalent live-attenuated 3-dose vaccine composed of chimeras of yellow fever 17D and the four dengue viruses (CYD, also called Dengvaxia) completed phase 3 clinical testing in over 35,000 children leading to a recommendation that vacc…
View article: Faculty Opinions recommendation of Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques.
Faculty Opinions recommendation of Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques. Open
View article: Use of the live attenuated Japanese Encephalitis vaccine SA 14–14–2 in children: A review of safety and tolerability studies
Use of the live attenuated Japanese Encephalitis vaccine SA 14–14–2 in children: A review of safety and tolerability studies Open
Japanese encephalitis (JE) is the leading cause of viral neurological disease and disability in Asia. Some 50-80% of children with clinical JE die or have long-term neurologic sequelae. Since there is no cure, human vaccination is the only…