Scott C. Grindy
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View article: Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering
Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering Open
This study presents the design, fabrication, and evaluation of a general platform for the creation of three-dimensional printed devices (3DPDs) for tissue engineering applications. As a demonstration, we modeled the liver with 3DPDs consis…
View article: Longitudinal Model of Periprosthetic Joint Infection in the Rat
Longitudinal Model of Periprosthetic Joint Infection in the Rat Open
The majority of periprosthetic joint infections occur shortly after primary joint replacement (<3 months) and require the removal of all implant components for the treatment period (~4 months). A clinically relevant animal model of peripro…
View article: Antimicrobial effect of anesthetic‐eluting ultra‐high molecular weight polyethylene for post‐arthroplasty antibacterial prophylaxis
Antimicrobial effect of anesthetic‐eluting ultra‐high molecular weight polyethylene for post‐arthroplasty antibacterial prophylaxis Open
Despite being a relatively safe surgery, total joint replacement is often associated with two major complications—severe post‐operative pain and periprosthetic joint infection. Local sustained delivery of therapeutics to the surgical site …
View article: Mucins trigger dispersal of Pseudomonas aeruginosa biofilms
Mucins trigger dispersal of Pseudomonas aeruginosa biofilms Open
Mucus is a biological gel that lines all wet epithelia in the body, including the mouth, lungs, and digestive tract, and has evolved to protect the body from pathogenic infection. However, microbial pathogenesis is often studied in mucus-f…
View article: Charge influences substrate recognition and self-assembly of hydrophobic FG sequences
Charge influences substrate recognition and self-assembly of hydrophobic FG sequences Open
The nuclear pore complex controls the passage of molecules via hydrophobic phenylalanine-glycine (FG) domains on nucleoporins. Such FG-domains consist of repeating units of FxFG, FG, or GLFG sequences, which can be interspersed with highly…
View article: Engineering Elasticity and Relaxation Time in Metal-Coordinate Cross-Linked Hydrogels
Engineering Elasticity and Relaxation Time in Metal-Coordinate Cross-Linked Hydrogels Open
Reversible cross-links between polymer chains are a promising avenue to engineer the mechanical properties of soft materials and in particular hydrogels. Such developments are however challenged by the complexity of these materials, which …