Scott C. Tadler
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View article: Propofol for treatment resistant depression: A randomized controlled trial
Propofol for treatment resistant depression: A randomized controlled trial Open
Background Anesthetic agents including ketamine and nitrous oxide have shown antidepressant properties when appropriately dosed. Our recent open-label trial of propofol, an intravenous anesthetic known to elicit transient positive mood eff…
View article: Diversity of electroencephalographic patterns during propofol-induced burst suppression
Diversity of electroencephalographic patterns during propofol-induced burst suppression Open
Burst suppression is a brain state consisting of high-amplitude electrical activity alternating with periods of quieter suppression that can be brought about by disease or by certain anesthetics. Although burst suppression has been studied…
View article: A Reinforcement Learning Based Control Approach for Propofol-Induced Burst Suppression
A Reinforcement Learning Based Control Approach for Propofol-Induced Burst Suppression Open
High-dose propofol is being investigated for its potential antidepressant effect. Propofol is titrated to induce burst suppression, a specific EEG pattern. However, propofol is difficult to dose due to uncertainty in each patient’s pharmac…
View article: Model-Based Propofol Dosing to Improve Control of Patient EEG Dynamics
Model-Based Propofol Dosing to Improve Control of Patient EEG Dynamics Open
Propofol is a common anesthetic, which is being investigated as an antidepressant alternative to electroconvulsive therapy (ECT). Propofol can induce similar EEG effects to that of ECT, and has also demonstrated similar improvements in dep…
View article: Propofol for Treatment-Resistant Depression: A Pilot Study
Propofol for Treatment-Resistant Depression: A Pilot Study Open
These findings demonstrate that high-dose propofol treatment is feasible and well tolerated by individuals with treatment-resistant depression who are otherwise healthy. Propofol may trigger rapid, durable antidepressant effects similar to…
View article: Tertiary Care Clinical Experience with Intravenous Lidocaine Infusions for the Treatment of Chronic Pain
Tertiary Care Clinical Experience with Intravenous Lidocaine Infusions for the Treatment of Chronic Pain Open
Our retrospective study in a heterogeneous population with chronic pain suggests that intravenous lidocaine is a safe treatment. Data also suggest long-term pain relief in a significant proportion of patients. Additional study is important…
View article: Correction: Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression
Correction: Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression Open
[This corrects the article DOI: 10.1371/journal.pone.0069809.].
View article: (254) Gene expression factor analysis differentiates pathways linked to pain, fatigue, and depression in a diverse patient sample
(254) Gene expression factor analysis differentiates pathways linked to pain, fatigue, and depression in a diverse patient sample Open