Scott Cherry
YOU?
Author Swipe
View article: Safer Prescribing in Behavioural and Psychological Symptoms of Dementia (BPSD): Reducing Anticholinergic Burden
Safer Prescribing in Behavioural and Psychological Symptoms of Dementia (BPSD): Reducing Anticholinergic Burden Open
Aims: NICE guidelines (NG97) emphasize the importance of assessing the anticholinergic burden of medications in older adults. Anticholinergic side effects of medications can worsen constipation, urinary retention, sedation and confusion, e…
View article: <scp>P1</scp>′ specificity of the <scp>S219V</scp>/<scp>R203G</scp> mutant tobacco etch virus protease
<span>P1</span>′ specificity of the <span>S219V</span>/<span>R203G</span> mutant tobacco etch virus protease Open
Proteases that recognize linear amino acid sequences with high specificity became indispensable tools of recombinant protein technology for the removal of various fusion tags. Due to its stringent sequence specificity, the catalytic domain…
View article: Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design
Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design Open
Dihydroneopterin aldolase (DHNA) is essential for folate biosynthesis in microorganisms. Without a counterpart in mammals, DHNA is an attractive target for antimicrobial agents. Helicobacter pylori infection occurs in human stomach of over…
View article: Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases
Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases Open
ATP-dependent Lon proteases are key participants in the quality control system that supports the homeostasis of the cellular proteome. Based on their unique structural and biochemical properties, Lon proteases have been assigned in the MER…
View article: Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus
Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus Open
N -hydroxylating flavin-dependent monooxygenases (FMOs) are involved in the biosynthesis of hydroxamate siderophores, playing a key role in microbial virulence. Herein, we report the first structural and kinetic characterization of a novel…
View article: Structure and activity of PPX/GppA homologs from <i>Escherichia coli</i> and <i>Helicobacter pylori</i>
Structure and activity of PPX/GppA homologs from <i>Escherichia coli</i> and <i>Helicobacter pylori</i> Open
Rapid adaptation to environmental changes is crucial for bacterial survival. Almost all bacteria possess a conserved stringent response system to prompt transcriptional and metabolic responses toward stress. The adaptive process relies on …
View article: Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery
Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery Open
Energy-dependent Lon proteases play a key role in cellular regulation by degrading short-lived regulatory proteins and misfolded proteins in the cell. The structure of the catalytically inactive S679A mutant of Escherichia coli LonA protea…
View article: Crystallographic study of dihydroneopterin aldolase from <i>Helicobacter pylori</i>
Crystallographic study of dihydroneopterin aldolase from <i>Helicobacter pylori</i> Open
Helicobacter pylori infection can lead to stomach cancer and colorectal cancer.The successful cure of H. pylori has been reduced by drug resistance.The urgency to develop novel antibiotics against H. pylori has fueled continued interest in…
View article: Targeting Protein–Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds
Targeting Protein–Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds Open
Chemical library screening approaches that focus exclusively on catalytic events may overlook unique effects of protein-protein interactions that can be exploited for development of specific inhibitors. Phosphotyrosyl (pTyr) residues embed…
View article: Binding mode of C/EBPβ and SMAD3 to the p15INK4b promoter
Binding mode of C/EBPβ and SMAD3 to the p15INK4b promoter Open
The basic region:leucine zipper (bZIP) DNA-binding protein, C/EBPβ is a key regulator of numerous cellular processes, but can also contribute to tumorigenesis and to viral diseases.It binds to specific DNA sites as homo-or hetero-dimer and…
View article: Crystal structure of the human dual specificity phosphatase 1 catalytic domain
Crystal structure of the human dual specificity phosphatase 1 catalytic domain Open
The dual specificity phosphatase DUSP1 was the first mitogen activated protein kinase phosphatase (MKP) to be identified. It dephosphorylates conserved tyrosine and threonine residues in the activation loops of mitogen activated protein ki…