Scott D. Gordon
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View article: Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping
Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping Open
Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association study (GWAS) of DSM-defined lifetime Major Depressive Disorder (MDD) in…
View article: Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes Open
View article: Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa Open
Anorexia nervosa (AN) has extensive genetic correlations with other psychiatric disorders, and genetic risk for different psychiatric disorders was associated with distinct clinical courses in AN. Uncovering associations between transdiagn…
View article: Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA
Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA Open
Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic well-being, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We …
View article: Polygenic prediction of body mass index and obesity through the life course and across ancestries
Polygenic prediction of body mass index and obesity through the life course and across ancestries Open
View article: Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk
Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk Open
Background Both genetic and environmental factors contribute to the risk of developing disordered eating, with twin studies demonstrating environmental factors moderate genetic susceptibility. To date, gene–environment interactions leverag…
View article: Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity
Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity Open
Importance The clinical heterogeneity of bipolar disorder (BD) is a major obstacle to improving diagnosis, predicting patient outcomes, and developing personalized treatments. A genetic approach is needed to deconstruct the disorder and un…
View article: Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes Open
View article: Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts
Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts Open
Introduction Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early yo…
View article: Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping
Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping Open
Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association (GWAS) mega-analysis of DSM-defined lifetime major depressive disorder …
View article: Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes Open
Eating disorders—including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder—are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first gen…
View article: Associations between common genetic variants and income provide insights about the socio-economic health gradient
Associations between common genetic variants and income provide insights about the socio-economic health gradient Open
View article: Genomics yields biological and phenotypic insights into bipolar disorder
Genomics yields biological and phenotypic insights into bipolar disorder Open
Bipolar disorder is a leading contributor to the global burden of disease1. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown2. We analysed data from participants o…
View article: Genome-wide copy number variation association study in anorexia nervosa
Genome-wide copy number variation association study in anorexia nervosa Open
View article: Genome-wide copy number variation association study in anorexia nervosa
Genome-wide copy number variation association study in anorexia nervosa Open
View article: Parkinson's Disease Polygenic Risk Score and Neurological Involvement in Carriers of the <scp><i>FMR1</i></scp> Premutation Allele: A Case for Genetic Modifier
Parkinson's Disease Polygenic Risk Score and Neurological Involvement in Carriers of the <span><i>FMR1</i></span> Premutation Allele: A Case for Genetic Modifier Open
Background Premutation alleles of the FMR1 X‐linked gene containing CGG repeat expansions ranging from 55 to 200 are associated with diverse late‐onset neurological involvements, including most severe disorder termed Fragile X‐associated T…
View article: Genetic architecture reconciles linkage and association studies of complex traits
Genetic architecture reconciles linkage and association studies of complex traits Open
View article: Anorexia nervosa polygenic risk, beyond diagnoses: relationship with adolescent disordered eating and behaviors in an Australian female twin population
Anorexia nervosa polygenic risk, beyond diagnoses: relationship with adolescent disordered eating and behaviors in an Australian female twin population Open
Background It is well established that there is a substantial genetic component to eating disorders (EDs). Polygenic risk scores (PRSs) can be used to quantify cumulative genetic risk for a trait at an individual level. Recent studies sugg…
View article: Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA
Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA Open
Romantic (typically sexual) relationships are important to personal, physical, mental, social, and economic wellbeing, and to human evolution. Yet little is known about factors contributing to long-term lack of intimate relationships. We i…
View article: Dyslexia Polygenic Scores Show Heightened Prediction of Verbal Working Memory and Arithmetic
Dyslexia Polygenic Scores Show Heightened Prediction of Verbal Working Memory and Arithmetic Open
Purpose: The aim of this study is to establish which specific cognitive abilities are phenotypically related to reading skill in adolescence and determine whether this phenotypic correlation is explained by polygenetic overlap. Method: In …
View article: Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis
Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis Open
Background and Hypothesis Schizophrenia (SCZ) and anorexia nervosa (AN) are 2 severe and highly heterogeneous disorders showing substantial familial co-aggregation. Genetic factors play a significant role in both disorders, but the shared …
View article: Genetics of environmental sensitivity to psychiatric and neurodevelopmental phenotypes: evidence from GWAS of monozygotic twins
Genetics of environmental sensitivity to psychiatric and neurodevelopmental phenotypes: evidence from GWAS of monozygotic twins Open
View article: Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes
Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes Open
Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder for which genetic factors explain up to 75% of the variance. In this study, we performed a genome-wide association meta-analysis (GWAMA) of ADHD sym…
View article: Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Open
View article: Potential causal association between gut microbiome and posttraumatic stress disorder
Potential causal association between gut microbiome and posttraumatic stress disorder Open
View article: X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements Open
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-rel…
View article: X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements Open
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-rel…
View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common…
View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient ( N =668,288). We found 162 genomic loci associated with a comm…
View article: Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity Open
STUDY QUESTION Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB…