Simon Gaisford
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View article: Effects of a Four‐Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial
Effects of a Four‐Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial Open
Background Gut dysbiosis and gut‐brain‐axis involvement in people with Parkinson's disease ( PwP ) support the use of gut‐microbiota‐modulating interventions. Probiotics may help manage constipation in PwP ; however, mechanisms underpinnin…
View article: Enhanced anti-P. aeruginosa treatment via phage and ciprofloxacin co-loaded particles prepared by electrospraying
Enhanced anti-P. aeruginosa treatment via phage and ciprofloxacin co-loaded particles prepared by electrospraying Open
Antimicrobial resistance (AMR) poses a critical global health challenge, contributing to an estimated 1.27 million deaths worldwide due to bacterial infections in 2019. Phages offer a possible solution to this, but alone have been found to…
View article: Ciprofloxacin-loaded electrosprayed lactose particles
Ciprofloxacin-loaded electrosprayed lactose particles Open
Bacterial infections persist as a major global health challenge, underscoring the need for the development of advanced drug delivery systems. This study firstly explored the use of electrospraying to generate lactose microparticles loaded …
View article: Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota
Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota Open
Biological ageing is a time-dependent process that has implications for health and disease. Cellular senescence is a key driver in ageing and age-related diseases. Senotherapeutic agents have been shown to slow biological ageing by elimina…
View article: Anti-Pseudomonas aeruginosa phage-loaded electrosprayed lactose particles
Anti-Pseudomonas aeruginosa phage-loaded electrosprayed lactose particles Open
View article: Ciprofloxacin-Loaded Spray-Dried Lactose Particles: Formulation Optimization and Antibacterial Efficacy
Ciprofloxacin-Loaded Spray-Dried Lactose Particles: Formulation Optimization and Antibacterial Efficacy Open
Background/Objectives: Bacterial infections in the oral cavity and outer ear require effective and targeted drug delivery systems. This study details the production of drug-loaded lactose microparticles, with the aim of creating antibiotic…
View article: Effects of senotherapeutics on gut microbiome dysbiosis and intestinal inflammation in Crohn's disease: A pilot study
Effects of senotherapeutics on gut microbiome dysbiosis and intestinal inflammation in Crohn's disease: A pilot study Open
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, and is usually accompanied by dysbiosis in the gut microbiome, a factor that contributes to disease progression. Excessive production …
View article: Anti‐Pseudomonas Aeruginosa Bacteriophage Loaded Electrospun Fibers for Antibacterial Wound Dressings
Anti‐Pseudomonas Aeruginosa Bacteriophage Loaded Electrospun Fibers for Antibacterial Wound Dressings Open
Antimicrobial resistance poses a growing threat to public health globally. Multidrug resistant Pseudomonas (P.) aeruginosa is detected in many infected wounds and is very challenging to treat with antibiotics. An alternative to antibiotics…
View article: A water-based probiotic supplement shows antipathogenic activity against Clostridium perfringens, Klebsiella pneumoniae, and Listeria monocytogenes
A water-based probiotic supplement shows antipathogenic activity against Clostridium perfringens, Klebsiella pneumoniae, and Listeria monocytogenes Open
View article: Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels
Volumetric printing and non-destructive drug quantification of water-soluble supramolecular hydrogels Open
Vat photopolymerisation 3D printing is being actively explored for manufacturing personalised medicines due to its high dimensional accuracy and lack of heat application. However, several challenges have hindered its clinical translation, …
View article: Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing
Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing Open
Selective laser sintering (SLS) is an emerging three-dimensional (3D) printing technology that uses a laser to fuse powder particles together, which allows the fabrication of personalized solid dosage forms. It possesses great potential fo…
View article: Exploring the interactions of JAK inhibitor and S1P receptor modulator drugs with the human gut microbiome: Implications for colonic drug delivery and inflammatory bowel disease
Exploring the interactions of JAK inhibitor and S1P receptor modulator drugs with the human gut microbiome: Implications for colonic drug delivery and inflammatory bowel disease Open
The gut microbiota is a complex ecosystem, home to hundreds of bacterial species and a vast repository of enzymes capable of metabolising a wide range of pharmaceuticals. Several drugs have been shown to affect negatively the composition a…
View article: 3D printed electro-responsive system with programmable drug release
3D printed electro-responsive system with programmable drug release Open
View article: Contents
Contents Open
View article: Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short chain fatty acids
Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short chain fatty acids Open
The production of short chain fatty acids (SCFAs) by the colonic microbiome has numerous benefits for human health, including maintenance of epithelial barrier function, suppression of colitis, and protection against carcinogenesis. Despit…
View article: Artificial intelligence generates novel 3D printing formulations
Artificial intelligence generates novel 3D printing formulations Open
Formulation development is a critical step in the development of medicines. The process requires human creativity, ingenuity and in-depth knowledge of formulation development and processing optimization, which can be time-consuming. Herein…
View article: Bacterial isolates from positive paired venous catheter and peripheral blood cultures taken during parenteral nutrition were the same species but different strains: A case report
Bacterial isolates from positive paired venous catheter and peripheral blood cultures taken during parenteral nutrition were the same species but different strains: A case report Open
This case report indicates consideration should be given to reporting whether bacteria have been identified at either species or strain level if differential time to positivity or differential quantitative blood cultures are used to define…
View article: The role of artificial intelligence in generating original scientific research
The role of artificial intelligence in generating original scientific research Open
Artificial intelligence (AI) is a revolutionary technology that is finding wide application across numerous sectors. Large language models (LLMs) are an emerging subset technology of AI and have been developed to communicate using human la…
View article: 3D Printed Electro-Responsive System with Programmable Drug Release
3D Printed Electro-Responsive System with Programmable Drug Release Open
View article: Ciprofloxacin-loaded electrospun nanofibres for antibacterial wound dressings
Ciprofloxacin-loaded electrospun nanofibres for antibacterial wound dressings Open
A wound is an injury that damages the normal structure and function of the skin and the underlying tissue. Disruption of the wound healing process causes chronic wounds, which are usually associated with microbial infections. In this work,…
View article: The potential for isothermal microcalorimetry to detect venous catheter infection isolates and establish antibiograms
The potential for isothermal microcalorimetry to detect venous catheter infection isolates and establish antibiograms Open
Isothermal microcalorimetry is a promising and highly reproducible real-time measurement technique with potential application to the investigation, species identification, and targeted antibiotic treatment of bloodstream infection and veno…
View article: Virtually Possible: Enhancing Quality Control of 3D-Printed Medicines with Machine Vision Trained on Photorealistic Images
Virtually Possible: Enhancing Quality Control of 3D-Printed Medicines with Machine Vision Trained on Photorealistic Images Open
Three-dimensional (3D) printing is an advanced pharmaceutical manufacturing technology, and concerted efforts are underway to establish its applicability to various industries. However, for any technology to achieve widespread adoption, ro…
View article: Optimizing environmental sustainability in pharmaceutical 3D printing through machine learning
Optimizing environmental sustainability in pharmaceutical 3D printing through machine learning Open
3D Printing (3DP) of pharmaceuticals could drastically transform the manufacturing of medicines and facilitate the widespread availability of personalised healthcare. However, with increasing awareness of the environmental damage of manufa…
View article: Electroactive Polymers for On‐Demand Drug Release
Electroactive Polymers for On‐Demand Drug Release Open
Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of daily life. Conductive polymers (CPs) are an…
View article: Supramolecular chemistry enables vat photopolymerization 3D printing of novel water-soluble tablets
Supramolecular chemistry enables vat photopolymerization 3D printing of novel water-soluble tablets Open
Vat photopolymerization has garnered interest from pharmaceutical researchers for the fabrication of personalised medicines, especially for drugs that require high precision dosing or are heat labile. However, the 3D printed structures cre…
View article: Polymorphic transitions in flufenamic acid-trehalose composites
Polymorphic transitions in flufenamic acid-trehalose composites Open
The combination of poorly-soluble drugs with small molecule co-formers to generate amorphous solid dispersions (ASDs) has great potential to improve dissolution rate and kinetic solubility, and thus increase the bioavailability of these ac…
View article: Real time microcalorimetric profiling of prebiotic inulin metabolism
Real time microcalorimetric profiling of prebiotic inulin metabolism Open
The in vitro assessment of prebiotics involves elaborate microbiological techniques or a combination of culture techniques and molecular methods. In this study, the isothermal microcalorimeter, an instrument which can monitor the real time…
View article: A case study on decentralized manufacturing of 3D printed medicines
A case study on decentralized manufacturing of 3D printed medicines Open
View article: CCDC 2221488: Experimental Crystal Structure Determination
CCDC 2221488: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2221495: Experimental Crystal Structure Determination
CCDC 2221495: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …