Scott E. Battle
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View article: Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation
Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation Open
Attachment of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells is critical for colonization and is associated with localized actin assembly beneath bound bacteria. The formation of these actin “pedestals” is depende…
View article: Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation
Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation Open
Upon infection of mammalian cells, enterohemorrhagic E. coli (EHEC) O157:H7 utilizes a type III secretion system to translocate the effectors Tir and EspF(U) (aka TccP) that trigger the formation of F-actin-rich 'pedestals' beneath bound b…
View article: Hybrid Pathogenicity Island PAGI-5 Contributes to the Highly Virulent Phenotype of a <i>Pseudomonas aeruginosa</i> Isolate in Mammals
Hybrid Pathogenicity Island PAGI-5 Contributes to the Highly Virulent Phenotype of a <i>Pseudomonas aeruginosa</i> Isolate in Mammals Open
Most known virulence determinants of Pseudomonas aeruginosa are remarkably conserved in this bacterium's core genome, yet individual strains differ significantly in virulence. One explanation for this discrepancy is that pathogenicity isla…
View article: Biochemical and Genetic Characterization of PspE and GlpE, Two Single-domain Sulfurtransferases of Escherichia coli
Biochemical and Genetic Characterization of PspE and GlpE, Two Single-domain Sulfurtransferases of Escherichia coli Open
The pspE and glpE genes of Escherichia coli encode periplasmic and cytoplasmic single-domain rhodaneses, respectively, that catalyzes sulfur transfer from thiosulfate to thiophilic acceptors. Strains deficient in either or both genes were …
View article: Secretion of the Toxin ExoU Is a Marker for Highly Virulent<i>Pseudomonas aeruginosa</i>Isolates Obtained from Patients with Hospital‐Acquired Pneumonia
Secretion of the Toxin ExoU Is a Marker for Highly Virulent<i>Pseudomonas aeruginosa</i>Isolates Obtained from Patients with Hospital‐Acquired Pneumonia Open
Overall, hospital-acquired pneumonia (HAP) caused by Pseudomonas aeruginosa is associated with high attributable mortality. Although the intrinsic virulence of P. aeruginosa undoubtedly contributes to this phenomenon, it is unclear whether…