Scott E. Phillips
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View article: A ferret model demonstrates sustained fibrosis, restrictive physiology, and airway proximalization
A ferret model demonstrates sustained fibrosis, restrictive physiology, and airway proximalization Open
Unlike rodents, ferrets have human-like distribution of submucosal glands expressing MUC5B, associated with idiopathic pulmonary fibrosis (IPF). We evaluated ferrets exposed to a single dose of bleomycin (5 U/kg) longitudinally, and found …
View article: ACE-2 blockade and TMPRSS2 inhibition mitigate SARS-CoV-2 severity following cigarette smoke exposure in airway epithelial cells in vitro
ACE-2 blockade and TMPRSS2 inhibition mitigate SARS-CoV-2 severity following cigarette smoke exposure in airway epithelial cells in vitro Open
View article: ACE-2 Blockade & TMPRSS2 Inhibition Mitigate SARS-CoV-2 Severity Following Cigarette Smoke Exposure in Airway Epithelial Cells In Vitro
ACE-2 Blockade & TMPRSS2 Inhibition Mitigate SARS-CoV-2 Severity Following Cigarette Smoke Exposure in Airway Epithelial Cells In Vitro Open
Cigarette smoking is associated with COVID-19 prevalence and severity, but the mechanistic basis for how smoking alters SARS-CoV-2 pathogenesis is unknown. A potential explanation is that smoking alters the expression of the SARS-CoV-2 cel…
View article: Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair
Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair Open
Rationale The role of MUC5B mucin expression in IPF pathogenesis is unknown. Bleomycin-exposed rodent models do not exhibit sustained fibrosis or airway remodeling. Unlike mice, ferrets have human-like distribution of MUC5B expressing cell…
View article: Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection
Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection Open
Substantial clinical evidence supports the notion that ciliary function in the airways is important in COVID-19 pathogenesis. Although ciliary damage has been observed in both in vitro and in vivo models, the extent or nature of impairment…
View article: The pathologies associated with functional titration of phosphatidylinositol transfer protein α activity in mice
The pathologies associated with functional titration of phosphatidylinositol transfer protein α activity in mice Open
Phosphatidylinositol transfer proteins (PITPs) bind phosphatidylinositol (PtdIns) and phosphatidylcholine and play diverse roles in coordinating lipid metabolism/signaling with intracellular functions. The underlying mechanisms remain uncl…
View article: Mice Lacking Phosphatidylinositol Transfer Protein-α Exhibit Spinocerebellar Degeneration, Intestinal and Hepatic Steatosis, and Hypoglycemia
Mice Lacking Phosphatidylinositol Transfer Protein-α Exhibit Spinocerebellar Degeneration, Intestinal and Hepatic Steatosis, and Hypoglycemia Open
Phosphatidylinositol transfer proteins (PITPs) regulate the interface between lipid metabolism and cellular functions. We now report that ablation of PITP alpha function leads to aponecrotic spinocerebellar disease, hypoglycemia, and intes…
View article: Specific and Nonspecific Membrane-binding Determinants Cooperate in Targeting Phosphatidylinositol Transfer Protein beta-Isoform to the Mammalian Trans-Golgi Network
Specific and Nonspecific Membrane-binding Determinants Cooperate in Targeting Phosphatidylinositol Transfer Protein beta-Isoform to the Mammalian Trans-Golgi Network Open
Phosphatidylinositol transfer proteins (PITPs) regulate the interface between lipid metabolism and specific steps in membrane trafficking through the secretory pathway in eukaryotes. Herein, we describe the cis-acting information that cont…
View article: Genetic Ablation of Phosphatidylinositol Transfer Protein Function in Murine Embryonic Stem Cells
Genetic Ablation of Phosphatidylinositol Transfer Protein Function in Murine Embryonic Stem Cells Open
Phosphatidylinositol transfer proteins (PITPs) regulate the interface between signal transduction, membrane-trafficking, and lipid metabolic pathways in eukaryotic cells. The best characterized mammalian PITPs are PITPα and PITPβ, two high…
View article: Conformational Dynamics of the Major Yeast Phosphatidylinositol Transfer Protein Sec14p: Insight into the Mechanisms of Phospholipid Exchange and Diseases of Sec14p-Like Protein Deficiencies
Conformational Dynamics of the Major Yeast Phosphatidylinositol Transfer Protein Sec14p: Insight into the Mechanisms of Phospholipid Exchange and Diseases of Sec14p-Like Protein Deficiencies Open
Molecular dynamics simulations coupled with functional analyses of the major yeast phosphatidylinositol/phosphatidylcholine transfer protein Sec14p identify structural elements involved in regulating the ability of Sec14p to execute phosph…
View article: Moving Mucus Matters for Lung Health
Moving Mucus Matters for Lung Health Open
When we breathe, the lungs exchange oxygen from the air for carbon dioxide waste from the blood. This exchange is vital for life. Each breath exposes the lungs to the outside environment, which contains pollution and germs, posing a threat…
View article: Seeing cilia: imaging modalities for ciliary motion and clinical connections
Seeing cilia: imaging modalities for ciliary motion and clinical connections Open
The respiratory tract is lined with multiciliated epithelial cells that function to move mucus and trapped particles via the mucociliary transport apparatus. Genetic and acquired ciliopathies result in diminished mucociliary clearance, con…
View article: Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function
Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function Open
View article: Dynamic DNA methylation regulates neuronal intrinsic membrane excitability
Dynamic DNA methylation regulates neuronal intrinsic membrane excitability Open
The intrinsic excitability of cortical pyramidal neurons is set by dynamic DNA cytosine methylation.
View article: Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS
Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS Open
Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously …
View article: DNA methylation regulates neuronal glutamatergic synaptic scaling
DNA methylation regulates neuronal glutamatergic synaptic scaling Open
Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.
View article: Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction Open