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View article: 87P Health-related quality of life (HRQoL) with maintenance niraparib: 6-month preliminary results from the MONITOR-UK trial
87P Health-related quality of life (HRQoL) with maintenance niraparib: 6-month preliminary results from the MONITOR-UK trial Open
View article: Patterns of crossover distribution in<i>Drosophila mauritiana</i>necessitate a re-thinking of the centromere effect on crossing over
Patterns of crossover distribution in<i>Drosophila mauritiana</i>necessitate a re-thinking of the centromere effect on crossing over Open
We present a SNP-based crossover map for Drosophila mauritiana . Using females derived by crossing two different strains of D . mauritiana , we analyzed crossing over on all five major chromosome arms. Analysis of 105 male progeny allowed …
View article: 52P MONITOR-UK: An initial analysis of a multi-centre, observational study of maintenance niraparib in ovarian cancer
52P MONITOR-UK: An initial analysis of a multi-centre, observational study of maintenance niraparib in ovarian cancer Open
Niraparib (PARP inhibitor) is approved in advanced ovarian cancer (OC) as maintenance therapy in the first line and recurrent platinum-sensitive settings. The MONITOR-UK study was designed to report real-world niraparib experience in UK cl…
View article: Refining Risk Stratification of High-risk and Locoregional Prostate Cancer: A Pooled Analysis of Randomized Trials
Refining Risk Stratification of High-risk and Locoregional Prostate Cancer: A Pooled Analysis of Randomized Trials Open
View article: Management of advanced prostate cancer in the Asia‐Pacific region: Summary of the Asia‐Pacific Advanced Prostate Cancer Consensus Conference 2023
Management of advanced prostate cancer in the Asia‐Pacific region: Summary of the Asia‐Pacific Advanced Prostate Cancer Consensus Conference 2023 Open
Aim The aim of the third Asia‐Pacific Advanced Prostate Cancer Consensus Conference (APAC APCCC 2023) was to discuss the application in the Asia‐Pacific (APAC) region of consensus statements from the 4th Advanced Prostate Cancer Consensus …
View article: Towards optimal heterogeneous prostate radiotherapy dose prescriptions based on patient‐specific or population‐based biological features
Towards optimal heterogeneous prostate radiotherapy dose prescriptions based on patient‐specific or population‐based biological features Open
Background Escalation of prescribed dose in prostate cancer (PCa) radiotherapy enables improvement in tumor control at the expense of increased toxicity. Opportunities for reduction of treatment toxicity may emerge if more efficient dose e…
View article: The GLP-1 receptor is expressed in vivo by human metastatic prostate cancer
The GLP-1 receptor is expressed in vivo by human metastatic prostate cancer Open
Objectives The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce in vitro proliferation and in vivo growth of prostate cancer cell lines. Prim…
View article: Validation of metastasis-free survival as a surrogate endpoint for overall survival in localized prostate cancer in the era of docetaxel for castration-resistant prostate cancer
Validation of metastasis-free survival as a surrogate endpoint for overall survival in localized prostate cancer in the era of docetaxel for castration-resistant prostate cancer Open
View article: Population‐based patient‐reported quality of life outcomes following low‐dose‐rate versus high‐dose‐rate brachytherapy monotherapy for low‐intermediate risk prostate cancer
Population‐based patient‐reported quality of life outcomes following low‐dose‐rate versus high‐dose‐rate brachytherapy monotherapy for low‐intermediate risk prostate cancer Open
Introduction To evaluate patient reported quality of life outcomes (QoL) following low‐dose‐rate brachytherapy (LDR‐BT) and high‐dose‐rate brachytherapy (HDR‐BT) monotherapy for prostate cancer at a population‐based setting. Methods The st…
View article: Copy number architectures define treatment-mediated selection of lethal prostate cancer clones
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Open
View article: Androgen Deprivation and Radiotherapy with or Without Docetaxel for Localized High-risk Prostate Cancer: Long-term Follow-up from the Randomized NRG Oncology RTOG 0521 Trial
Androgen Deprivation and Radiotherapy with or Without Docetaxel for Localized High-risk Prostate Cancer: Long-term Follow-up from the Randomized NRG Oncology RTOG 0521 Trial Open
View article: Detecting localised prostate cancer using radiomic features in PSMA PET and multiparametric MRI for biologically targeted radiation therapy
Detecting localised prostate cancer using radiomic features in PSMA PET and multiparametric MRI for biologically targeted radiation therapy Open
View article: Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures
Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures Open
Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient relationships of metastases that evade treatment, we performed genome-wide copy number profi…
View article: Semi-quantitative and quantitative dynamic contrast-enhanced (DCE) MRI parameters as prostate cancer imaging biomarkers for biologically targeted radiation therapy
Semi-quantitative and quantitative dynamic contrast-enhanced (DCE) MRI parameters as prostate cancer imaging biomarkers for biologically targeted radiation therapy Open
View article: A comparison of <scp>DNA</scp> sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primary
A comparison of <span>DNA</span> sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primary Open
Cancer of unknown primary (CUP) is a syndrome defined by clinical absence of a primary cancer after standardised investigations. Gene expression profiling (GEP) and DNA sequencing have been used to predict primary tissue of origin (TOO) in…
View article: Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss Open
View article: Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures
Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures Open
Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient relationships of metastases that evade treatment, we performed genomewide copy number profil…
View article: Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status
Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status Open
Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate cancer spread is caused by failure of the normal anti-cancer defense systems that are controlled by the tumo…
View article: DNA sequencing and gene-expression profiling assists in making a tissue of origin diagnosis in cancer of unknown primary
DNA sequencing and gene-expression profiling assists in making a tissue of origin diagnosis in cancer of unknown primary Open
Cancer of unknown primary (CUP) constitutes a group of metastatic cancers in which standardized clinical investigations fail to identify a tissue of origin (TOO). Gene-expression profiling (GEP) has been used to resolve TOO, and DNA sequen…
View article: Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes
Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes Open
Background Aberrations in homologous recombination repair (HRR) genes are emerging as important biomarkers for personalized treatment in prostate cancer (PCa). HRR deficiency (HRD) could affect the tumor immune microenvironment (TIME), pot…
View article: Managing advanced prostate cancer in the Asia Pacific region: “Real‐world” application of Advanced Prostate Cancer Consensus Conference 2019 statements
Managing advanced prostate cancer in the Asia Pacific region: “Real‐world” application of Advanced Prostate Cancer Consensus Conference 2019 statements Open
Aim The second Asia‐Pacific Advanced Prostate Cancer Consensus Conference (APAC APCCC 2020) gathered insights into the real‐world application in the Asia‐Pacific (APAC) region of consensus statements from the 3rd Advanced Prostate Cancer C…
View article: A statistical, voxelised model of prostate cancer for biologically optimised radiotherapy
A statistical, voxelised model of prostate cancer for biologically optimised radiotherapy Open
A biological model has been created that combines spatial distributions of tumour characteristics from a population into three-dimensional, voxelised, statistical models. This tool will be used to aid the development of biologically-optimi…
View article: Health-Related Quality of Life in Metastatic, Hormone-Sensitive Prostate Cancer: ENZAMET (ANZUP 1304), an International, Randomized Phase III Trial Led by ANZUP
Health-Related Quality of Life in Metastatic, Hormone-Sensitive Prostate Cancer: ENZAMET (ANZUP 1304), an International, Randomized Phase III Trial Led by ANZUP Open
PURPOSE We previously reported that enzalutamide improved overall survival when added to standard of care in metastatic, hormone-sensitive prostate cancer. Here, we report its effects on aspects of health-related quality of life (HRQL). ME…
View article: Biologically Targeted Radiation Therapy: Incorporating Patient-Specific Hypoxia Data Derived from Quantitative Magnetic Resonance Imaging
Biologically Targeted Radiation Therapy: Incorporating Patient-Specific Hypoxia Data Derived from Quantitative Magnetic Resonance Imaging Open
Purpose: Hypoxia has been linked to radioresistance. Strategies to safely dose escalate dominant intraprostatic lesions have shown promising results, but further dose escalation to overcome the effects of hypoxia require a novel approach t…
View article: Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression
Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression Open
View article: ‘Pain‐free TRUS B’: a phase 3 double‐blind placebo‐controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasonography‐guided prostate biopsy (ANZUP 1501)
‘Pain‐free TRUS B’: a phase 3 double‐blind placebo‐controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasonography‐guided prostate biopsy (ANZUP 1501) Open
Objective To determine whether the addition of inhaled methoxyflurane to periprostatic infiltration of local anaesthetic (PILA) during transrectal ultrasonography‐guided prostate biopsies (TRUSBs) improved pain and other aspects of the exp…
View article: <sup>68</sup>Ga‐prostate‐specific membrane antigen (PSMA) PET/CT as a clinical decision‐making tool in biochemically recurrent prostate cancer
<sup>68</sup>Ga‐prostate‐specific membrane antigen (PSMA) PET/CT as a clinical decision‐making tool in biochemically recurrent prostate cancer Open
Objective PSMA PET/CT has demonstrated superior sensitivity over conventional imaging in the detection of local and distant recurrence in biochemically relapsed (BCR) prostate cancer. We prospectively investigated the management impact of …
View article: Regulatory T Cells Shape the Differential Impact of Radiation Dose-Fractionation Schedules on Host Innate and Adaptive Antitumor Immune Defenses
Regulatory T Cells Shape the Differential Impact of Radiation Dose-Fractionation Schedules on Host Innate and Adaptive Antitumor Immune Defenses Open
Local radiation-induced Treg responses are influenced by radiation schedule and tumor type and are a critical determinant of the immunoadjuvant potential of RT and its ability to synergize with T cell-targeted immunotherapy.
View article: Additional file 1 of Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression
Additional file 1 of Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression Open
Additional file 1.
View article: Additional file 4 of Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression
Additional file 4 of Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression Open
Additional file 4.