Adam S. Hamlin
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View article: Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease
Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease Open
Sydenham chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF). ARF and rheumatic heart disease (RHD) are autoimmune complications triggered by a group A streptococcal (GAS) infection. In ARF/RHD and SC,…
View article: Approaches to inducing mental fatigue: A systematic review and meta-analysis of (neuro)physiologic indices
Approaches to inducing mental fatigue: A systematic review and meta-analysis of (neuro)physiologic indices Open
Mental fatigue is a transient psychophysiological state characterized by impaired cognition and behavior across a range of dynamic contexts. Despite increasing interest in this phenomenon, its (neuro)physiologic representations remain uncl…
View article: Neurobehavioral Changes Associated with Rheumatic Fever and Rheumatic Heart Disease: A Narrative Review
Neurobehavioral Changes Associated with Rheumatic Fever and Rheumatic Heart Disease: A Narrative Review Open
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune conditions triggered by Group A Streptococcus skin or throat infections. If ARF/RHD is undetected, misdiagnosed or antibiotic treatment is not provided early, pat…
View article: I remember you; Experimental evidence of true acoustic individual recognition in a wild passerine.
I remember you; Experimental evidence of true acoustic individual recognition in a wild passerine. Open
True individual recognition refers to an animal's ability to recognise at least one unique feature of another individual. Demonstrating this in animals equivocally can be difficult, as it requires confounding variables such as location, ki…
View article: Conflict and control in cortical responses to inconsistent emotional signals in a face-word Stroop
Conflict and control in cortical responses to inconsistent emotional signals in a face-word Stroop Open
Social communication is fraught with ambiguity. Negotiating the social world requires interpreting the affective signals we receive and often selecting between channels of conflicting affective information. The affective face-word Stroop (…
View article: Characterization of an experimental model to determine streptococcal M protein–induced autoimmune cardiac and neurobehavioral abnormalities
Characterization of an experimental model to determine streptococcal M protein–induced autoimmune cardiac and neurobehavioral abnormalities Open
Group A streptococcal (GAS) infection is associated with a spectrum of autoimmune diseases including acute rheumatic fever/rheumatic heart disease (ARF/RHD) and neurobehavioral abnormalities. Antibodies against GAS M proteins cross‐react w…
View article: Requirements for a Robust Animal Model to Investigate the Disease Mechanism of Autoimmune Complications Associated With ARF/RHD
Requirements for a Robust Animal Model to Investigate the Disease Mechanism of Autoimmune Complications Associated With ARF/RHD Open
The pathogenesis of Acute Rheumatic Fever/Rheumatic Heart Disease (ARF/RHD) and associated neurobehavioral complications including Sydenham's chorea (SC) is complex. Disease complications triggered by Group A streptococcal (GAS) infection …
View article: Group A streptococcal antigen exposed rat model to investigate neurobehavioral and cardiac complications associated with post‐streptococcal autoimmune sequelae
Group A streptococcal antigen exposed rat model to investigate neurobehavioral and cardiac complications associated with post‐streptococcal autoimmune sequelae Open
Background The neuropsychiatric disorders due to post‐streptococcal autoimmune complications such as Sydenham's chorea (SC) are associated with acute rheumatic fever and rheumatic heart disease (ARF/RHD). An animal model that exhibits char…
View article: Quantitative determination of neuronal size and density using flow cytometry
Quantitative determination of neuronal size and density using flow cytometry Open
Use of flow cytometry provides a methodological approach that allows for consistency in research, so that information on brain morphology, and subsequent function, will become comparable across taxa.
View article: Frequent Visits to an Outdoor Range and Lower Areas of an Aviary System Is Related to Curiosity in Commercial Free-Range Laying Hens
Frequent Visits to an Outdoor Range and Lower Areas of an Aviary System Is Related to Curiosity in Commercial Free-Range Laying Hens Open
Individual hen preferences to spend time at particular locations within a free-range aviary system and relationships with temperament is relatively unknown. Hens (n = 769) from three commercial flocks were monitored with Radio Frequency Id…
View article: Anticipatory Behavior for a Mealworm Reward in Laying Hens Is Reduced by Opioid Receptor Antagonism but Not Standard Feed Intake
Anticipatory Behavior for a Mealworm Reward in Laying Hens Is Reduced by Opioid Receptor Antagonism but Not Standard Feed Intake Open
It is widely accepted that the absence of suffering no longer defines animal welfare and that positive affective experiences are imperative. For example, laying hens may be housed in environments that do not cause chronic stress but may la…
View article: A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome
A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome Open
Objective: Serotonin reuptake inhibitors are the predominant treatment for major depressive disorder. In recent years, the diversity of the gut microbiota has emerged to play a significant role in the occurrence of major depressive disorde…
View article: Olive Biophenols Reduces Alzheimer’s Pathology in SH-SY5Y Cells and APPswe Mice
Olive Biophenols Reduces Alzheimer’s Pathology in SH-SY5Y Cells and APPswe Mice Open
Alzheimer’s disease (AD) is a major neurodegenerative disease, associated with the hallmark proteinacious constituent called amyloid beta (Aβ) of senile plaques. Moreover, it is already established that metals (particularly copper, zinc an…
View article: Olive (Olea europaea L.) Biophenols: A Nutriceutical against Oxidative Stress in SH-SY5Y Cells
Olive (Olea europaea L.) Biophenols: A Nutriceutical against Oxidative Stress in SH-SY5Y Cells Open
Plant biophenols have been shown to be effective in the modulation of Alzheimer’s disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and cop…