Scott Kerridge
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View article: A <i>Slc5a6</i> Deficient Mouse Model Reveals a Metabolically Driven Dilated Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention
A <i>Slc5a6</i> Deficient Mouse Model Reveals a Metabolically Driven Dilated Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention Open
Background and Aims The sodium-dependent multivitamin transporter, encoded by SLC5A6 , mediates cellular uptake of the vitamins, biotin and pantothenic acid, both of which are essential cofactors for energy metabolism. Here, we report two …
View article: Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway Open
Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report t…
View article: Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells Open
The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase inhibitors. While investigating the effect of either a c-Rel deletion or RelAT505A phos…
View article: Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway Open
We previously discovered that deletion of c-Rel in the Eμ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report th…