Explanipedia

Use of Extracorporeal Photopheresis Treatment Over Time (2001–2023) in Alberta, Canada: A Retrospective Cohort Study Open

Louis Girard, Sylvia Aponte-Hao, Jason R. Randall, Karen J. B. Martins, Huong Luu , et al. · 2025

Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: a retrospective cohort study from Alberta, Canada Open

Sylvia Aponte-Hao, Huong Luu, Karen J. B. Martins, Jason R. Randall, Lynora Saxinger , et al. · 2025

Background With a large proportion of adults in Canada vaccinated against SARS-CoV-2, it is important to identify who remain at risk for severe COVID-19 outcomes after primary vaccination/additional (booster) doses. Methods Adults (≥18 yea…

Persistence, Switching, and Healthcare Use after Initiating Calcitonin Gene-Related Peptide Inhibitors: A Real-world Assessment Open

Cristiano Soares de Moura, Jason R. Randall, Scott Klarenbach, Hassan Behlouli, Huong Luu , et al. · 2025

Background:Migraine is a prevalent and disabling condition affecting one billion people worldwide. Calcitonin gene-related peptide (CGRP) inhibitors have transformed migraine management. We describe real-world trends in CGRP inhibitor trea…

A Cluster Randomized Trial of an mHealth Intervention for Adolescents With Congenital Heart Disease: Rationale and Design of the READYorNot CHD Study Open

Andrew S. Mackie, Adrienne H. Kovacs, Daniella San Martin-Feeney, Alicia Via-Dufresne Ley, Brian W. McCrindle , et al. · 2025

Protocol for ‘Re: CBT Dialysis’: a realist evaluation—why, for whom and in what circumstances does cognitive behaviour therapy work for people with depressive symptoms receiving dialysis? Open

Kara Schick‐Makaroff, Richard Sawatzky, Joanne Greenhalgh, Daniel Cukor, Hubert Wong , et al. · 2025

Introduction Nearly 40% of adults receiving life-saving dialysis for kidney failure report depressive symptoms. With more than 40 000 Canadians on dialysis, this is a significant health burden. Cognitive behavioural therapy (CBT) has been …

The Diagnostic Performance of Screening Instruments for Mild Cognitive Impairment and Dementia in Chronic Kidney Disease and Kidney Failure: A Systematic Review and Meta-analysis Open

Kevin Y. Wang, Andrea Razcόn Echeagaray, Sandy Campbell, Clara Bohm, Karthik Tennankore , et al. · 2025

Key performance indicators for acute intermittent kidney replacement therapy in critically ill patients: a protocol for a systematic review Open

Dawn Opgenorth, Liza Bialy, Kristin Robertson, Samantha L. Bowker, Selvi Sinnadurai , et al. · 2025

Introduction There have been previous initiatives to identify key performance indicators (KPIs) for continuous kidney replacement therapy. However, no formal reviews of the evidence for KPIs of intermittent kidney replacement therapy (IKRT…

The Healthcare Cost of Migraine: A Retrospective Cohort Study from Alberta, Canada Open

Phuong Uyen Nguyen, Huong Luu, Helen So, Khanh Vu, Karen J. B. Martins , et al. · 2025

Introduction: The economic burden of migraine is substantial; determining the cost that migraine imposes on the Canadian healthcare system is needed. Methods: Administrative data were used to identify adults living with migraine, including…

Testicular Pain After Living Kidney Donation: Results From a Multicenter Cohort Study Open

Amit X. Garg, Liane S. Feldman, Jessica M. Sontrop, Meaghan S. Cuerden, Jennifer Arnold , et al. · 2025

Background: Some men who donate a kidney have reported testicular pain after donation; however, attribution to donation is not clear as no prior studies included a comparison group of nondonors. Objective: To examine the proportion of male…

Developing and Tailoring a Person-Centred Pathway for Mental Health Care for People Receiving Dialysis Open

Kara Schick‐Makaroff, Charlotte Berendonk, Marlo Salum, Peter Yoeun, Jenny Wichart , et al. · 2025

Introduction: Mental health symptoms are underdiagnosed and undertreated among people receiving dialysis treatment. Despite a high prevalence of depression (40%) and anxiety (42%) symptoms in this population, international guidance does no…

Effectiveness of Patient Navigation During Transition to Adult Care Open

Susan Samuel, Zoya Punjwani, Daniella San Martin-Feeney, Brooke Allemang, Gregory M.T. Guilcher , et al. · 2025

Importance Transition to adult care is a challenging and complex process for youth and emerging adults with chronic health and/or mental health conditions. Patient navigation has been proposed to improve care during transition, but previou…

A205 IMPACT OF THE PANDEMIC ON BUDESONIDE MMX DISPENSING AND TREATMENT FAILURE IN ULCERATIVE COLITIS Open

Stephanie Coward, Karen J. B. Martins, Scott Klarenbach, Karen I. Kroeker, Chaoran Ma , et al. · 2025

Background Budesonide MMX is a locally acting corticosteroid with reduced side effects compared to prednisone. During the pandemic, budesonide MMX may have been preferred due to its favourable side effect profile. Aims To analyze rates of …

Inequities in the Use of Disease-Modifying Therapy Among Adults Living With Multiple Sclerosis in Urban and Rural Areas in Alberta, Canada Open

Erin F. Balcom, Jennifer A. McCombe, Mahesh Kate, Khanh Vu, Karen J. B. Martins , et al. · 2025

PwMS residing in rural (vs urban) Alberta are less likely to receive any DMT, especially induction/higher-efficacy therapy; this inequality may be mediated by socioeconomic status and geography. Identifying and overcoming barriers to optim…

The Real‐World Effectiveness of Human Immunodeficiency Virus Pre‐Exposure Prophylaxis in Adults in Alberta, Canada: A Retrospective Population‐Based Cohort Study Open

Elissa Rennert May, Mu Lin, Shannon L. Turvey, Derek S. Chew, Marcello Tonelli , et al. · 2025

Background: In clinical trials, pre‐exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate‐emtricitabine (TDF/FTC) or tenofovir alafenamide‐emtricitabine (TAF/FTC) is up to 99% efficacious in preventing human immunodeficiency virus…

Virtual consultation in kidney care: a mixed-methods study on a model for safe and effective integration into routine clinical care Open

Mark Courtney, Stephanie Thompson, Scott Klarenbach, Feng Ye, Deenaz Zaidi , et al. · 2025

Rationale and Objective Globally, the COVID-19 pandemic necessitated a rapid introduction of virtual care delivery via telephone or videoconference. The rapid advancements in e-health technology facilitated options for virtual care, includ…

Testicular pain after living kidney donation: Results from a multicenter cohort study Open

Amit Garg, Liane S. Feldman, Jessica M. Sontrop, Meaghan S. Cuerden, Jennifer M. Arnold , et al. · 2024

Background Some men who donate a kidney have reported testicular pain after donation; however, attribution to donation is not clear as no prior studies included a comparison group of nondonors. Objective To examine the proportion of male d…

Transition experiences of adolescents and young adults working with a patient navigator Open

Daniella San Martin-Feeney, Sophie Samborn, Brooke Allemang, Megan Patton, Zoya Punjwani , et al. · 2024

Associations Between Hearing Loss and Health-Related Costs: A Retrospective Population-Based Cohort Study Open

Marcello Tonelli, Natasha Wiebe, Tiffany Boulton, Maoliosa Donald, Julie Evans , et al. · 2024

Purpose: Hearing loss (HL) is a leading cause of disability worldwide, but its health-related costs have been incompletely studied. Our objective was to examine the association between HL and direct health care costs and identify subgroups…

Post-Stroke Spasticity Treatment: A Retrospective Cohort Study From Alberta, Canada Open

Lalith Satkunam, Sean P. Dukelow, Jaime C. Yu, Stephen McNeil, Huong Luu , et al. · 2024

Background: Understanding post-stroke spasticity (PSS) treatment in everyday clinical practice may guide improvements in patient care. Methods: This was a retrospective cohort study that used population-level administrative data. Adults (a…

Healthcare Cost of Multiple Sclerosis and in Relation to Disability Level in Alberta Open

Jennifer A. McCombe, Penelope Smyth, Mahesh Kate, Helen So, Khanh Vu , et al. · 2024

Background: We aimed to (1) report updated estimates of direct healthcare costs for people living with MS (pwMS), (2) contrast costs to a control population and (3) explore differences between disability levels among pwMS. Methods: Adminis…

Response Open

Michael R. Kolber, Adrienne J. Lindblad, Scott Klarenbach, G. Michael Allan · 2024

We thank Dr Aubrey-Bassler for his comment[1][1] pertaining to the PEER simplified lipid guideline 2023 update.[2][2] Both the 2023 and 2015 PEER simplified lipid guidelines do not recommend repeat lipid testing for primary or secondary pr…

Hypertension and Kidney Function After Living Kidney Donation Open

Amit Garg, Jennifer Arnold, Meaghan S. Cuerden, Christine Dipchand, Liane S. Feldman , et al. · 2024

Importance Recent guidelines call for better evidence on health outcomes after living kidney donation. Objective To determine the risk of hypertension in normotensive adults who donated a kidney compared with nondonors of similar baseline …

Biologic Drugs for Severe Asthma Open

Jason R. Randall, Richard Leigh, Ellen Crumley, Sylvia Aponte-Hao, Khanh Vu , et al. · 2024

Several biologic drugs are available to treat severe asthma. These biologics are designed to target specific inflammatory subtypes of asthma (eosinophilic or allergic). A Rapid Review was conducted to describe the evidence on the comparati…

Rituximab or cyclosporine A for the treatment of membranous nephropathy: economic evaluation of the MENTOR trial Open

Matthew Kadatz, Scott Klarenbach, Helen So, Fernando C. Fervenza, Daniel C. Cattran , et al. · 2024

Background and hypothesis The MENTOR trial (MEmbranous Nephropathy Trial Of Rituximab) showed that rituximab was noninferior to cyclosporine in inducing complete or partial remission of proteinuria and was superior in maintaining proteinur…

Global trends in chronic kidney disease-related mortality: a systematic review protocol Open

Somkanya Tungsanga, Anukul Ghimire, Vinash K Hariramani, Abdullah Abdulrahman, Ana S Khan , et al. · 2024

Introduction In recent decades, all-cause mortality has increased among individuals with chronic kidney disease (CKD), influenced by factors such as aetiology, standards of care and access to kidney replacement therapies (dialysis and tran…

Benzodiazepine use in medical cannabis authorization adult patients from 2013 to 2021: Alberta, Canada Open

Cerina Dubois, Heidi V.J. Fernandes, Mu Lin, Karen J. B. Martins, Jason R.B. Dyck , et al. · 2024

Background Benzodiazepines are a class of medications that are being frequently prescribed in Canada but carry significant risk of harm. There has been increasing clinical interest on the potential “sparing effects” of medical cannabis as …

Screening for lung cancer with computed tomography: protocol for systematic reviews for the Canadian Task Force on Preventive Health Care Open

Jennifer Pillay, Sholeh Rahman, Scott Klarenbach, Donna L. Reynolds, Laure Tessier , et al. · 2024

Personalizing cardiovascular risk: Coronary artery calcium scans to improve statin use in adults with type 2 diabetes can be cost‐effective in select individuals Open

Darren Lau, Glen J. Pearson, Paolo Raggi, Scott Klarenbach · 2024

Many adults with diabetes are not on a statin.1 A coronary artery calcium (CAC) scan provides a depiction of coronary artery disease and is predictive of cardiovascular (CV) risk. Showing and discussing CAC scan findings with patients has …

The impact of the Starting dialysis on Time, At home on the Right Therapy (START) project on the use of peritoneal dialysis Open

Robert R. Quinn, Matthew J. Oliver, Alix Clarke, Mohamed Farah, Scott Klarenbach , et al. · 2024

Background: Peritoneal dialysis (PD) is actively promoted, but increasing PD utilisation is difficult. The objective of this study was to determine if the Starting dialysis on Time, At Home, on the Right Therapy (START) project was associa…

Disease-modifying therapy use and health resource utilisation associated with multiple sclerosis over time: A retrospective cohort study from Alberta, Canada Open

Erin F. Balcom, Penelope Smyth, Mahesh Kate, Khanh Vu, Karen J. B. Martins , et al. · 2024

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