Scott McClain
YOU?
Author Swipe
View article: Editorial: What have we learned over the last 25 years assessing novel food and protein allergenicity
Editorial: What have we learned over the last 25 years assessing novel food and protein allergenicity Open
Editorial: What have we learned over the last 25 years assessing novel food and protein allergenicity
View article: Analysis of unintended open reading frame ORF-130 expression in maize event MZIR098 by LC-MS as part of the allergenicity risk assessment of genetically modified crops
Analysis of unintended open reading frame ORF-130 expression in maize event MZIR098 by LC-MS as part of the allergenicity risk assessment of genetically modified crops Open
Rigorous safety assessments are required for genetically modified (GM) crops to support their use as food or feed. These assessments include bioinformatics analysis of the amino acid sequences of all potential open reading frames (ORFs) en…
View article: 74 Automation, Machine Learning and Computer Vision as Decision Support: Taking What Animal Agricultural Does Well Into the Future
74 Automation, Machine Learning and Computer Vision as Decision Support: Taking What Animal Agricultural Does Well Into the Future Open
Commercial protein production involves ever more reliance on monitoring operations due to needs around disease intervention, animal loss, and optimized nutrition. With poultry flock and cattle herd sizes in the thousands, as two examples, …
View article: Impact of Food Matrices on Digestibility of Allergens and Poorly Allergenic Homologs
Impact of Food Matrices on Digestibility of Allergens and Poorly Allergenic Homologs Open
Background Protease resistance is considered a risk factor for allergenicity of proteins, although the correlation is low. It is nonetheless a part of the weight-of-evidence approach, proposed by Codex, for assessing the allergenicity risk…
View article: The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement
The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement Open
Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public saf…
View article: Allergy Risk Assessment for Newly Expressed Proteins (NEPs) in Genetically Modified (GM) Plants
Allergy Risk Assessment for Newly Expressed Proteins (NEPs) in Genetically Modified (GM) Plants Open
Based on experience and scientific advancements over the past two decades, a revised approach for the assessment of the allergenic potential of newly expressed proteins (NEPs) in genetically modified (GM) plants is warranted. NEPs are most…
View article: Core and Supplementary Studies to Assess the Safety of Genetically Modified (GM) Plants Used for Food and Feed
Core and Supplementary Studies to Assess the Safety of Genetically Modified (GM) Plants Used for Food and Feed Open
Genetically modified (GM) plants used for food and feed have an established history of safe use over more than 25 years of their commercialization. Developers and regulatory authorities have accumulated extensive experience in evaluating t…
View article: Variation in Seed Allergen Content From Three Varieties of Soybean Cultivated in Nine Different Locations in Iowa, Illinois, and Indiana
Variation in Seed Allergen Content From Three Varieties of Soybean Cultivated in Nine Different Locations in Iowa, Illinois, and Indiana Open
Soybean (Glycine max) is an important food stock, and also considered an allergenic food with at least eight well characterized allergens. However, it is a less prevalent allergen source than many other foods and is rarely life-threatening…
View article: Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure
Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure Open
Sub-optimal pH, low pepsin-to protein ratio, and sequential pepsin and pancreatin digestion protocols do not improve the predictive value in distinguish allergens from non-allergens. Digestion conditions facilitating such distinction diffe…
View article: Bioinformatic screening and detection of allergen cross‐reactive IgE‐binding epitopes
Bioinformatic screening and detection of allergen cross‐reactive IgE‐binding epitopes Open
Protein allergens can be related by cross‐reactivity. Allergens that share relevant sequence can cross‐react, those lacking sufficient similarity in their IgE antibody‐binding epitopes do not cross‐react. Cross‐reactivity is based on share…
View article: Inter-laboratory optimization of protein extraction, separation, and fluorescent detection of endogenous rice allergens
Inter-laboratory optimization of protein extraction, separation, and fluorescent detection of endogenous rice allergens Open
In rice, several allergens have been identified such as the non-specific lipid transfer protein-1, the α-amylase/trypsin-inhibitors, the α-globulin, the 33 kDa glyoxalase I (Gly I), the 52–63 kDa globulin, and the granule-bound starch synt…
View article: Inter-laboratory optimization of protein extraction, separation, and fluorescent detection of endogenous rice allergens
Inter-laboratory optimization of protein extraction, separation, and fluorescent detection of endogenous rice allergens Open
In rice, several allergens have been identified such as the non-specific lipid transfer protein-1, the α-amylase/trypsin-inhibitors, the α-globulin, the 33 kDa glyoxalase I (Gly I), the 52–63 kDa globulin, and the granule-bound starch synt…