Richard S. McLachlan
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View article: Nationwide Study of Postlegalization Marijuana Use Among Patients With Epilepsy in Canada
Nationwide Study of Postlegalization Marijuana Use Among Patients With Epilepsy in Canada Open
This study reveals a high prevalence of marijuana use among patients with epilepsy living in Canada particularly when seizures are drug resistant. A significant proportion of patients reported improvement of seizures with marijuana use, co…
View article: A.6 Vagus Nerve Stimulation in patients with therapy resistant generalized epilepsy
A.6 Vagus Nerve Stimulation in patients with therapy resistant generalized epilepsy Open
Background: For patients with generalized epilepsy who do not respond to anti-seizure medications, the therapeutic options are limited. Vagus nerve stimulation (VNS) is a treatment mainly approved for therapy resistant focal epilepsy. Ther…
View article: Effect of lifetime antiepileptic drug treatment history on efficacy and tolerability of adjunctive brivaracetam in adults with focal seizures: Post-hoc analysis of a randomized, placebo-controlled trial
Effect of lifetime antiepileptic drug treatment history on efficacy and tolerability of adjunctive brivaracetam in adults with focal seizures: Post-hoc analysis of a randomized, placebo-controlled trial Open
This post-hoc analysis suggests a numerically higher response to adjunctive BRV in patients with fewer lifetime AEDs. The lowest response was observed in patients with ≥7 lifetime AEDs, although these patients could also benefit from adjun…
View article: CJN volume 47 issue 3 Cover and Front matter
CJN volume 47 issue 3 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Seizure Freedom in Temporal Plus Epilepsy Surgery Following Stereo-Electroencephalography
Seizure Freedom in Temporal Plus Epilepsy Surgery Following Stereo-Electroencephalography Open
Background: “Temporal plus” epilepsy (TPE) is a term that is used when the epileptogenic zone (EZ) extends beyond the boundaries of the temporal lobe. Stereotactic electroencephalography (SEEG) has been essential to identify additional EZs…
View article: CJN volume 46 issue 6 Cover and Front matter
CJN volume 46 issue 6 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Position Statement on the Use of Medical Cannabis for the Treatment of Epilepsy in Canada
Position Statement on the Use of Medical Cannabis for the Treatment of Epilepsy in Canada Open
In Canada, recreational use of cannabis was legalized in October 2018. This policy change along with recent publications evaluating the efficacy of cannabis for the medical treatment of epilepsy and media awareness about its use have incre…
View article: Surgical treatment of extra‐hypothalamic epilepsies presenting with gelastic seizures
Surgical treatment of extra‐hypothalamic epilepsies presenting with gelastic seizures Open
We provide an overview of the surgical outcome of extra‐hypothalamic epilepsies with gelastic seizures based on an original case report and a summary of the literature. Twenty‐two articles providing information on the outcome of resective …
View article: CJN volume 45 issue 3 Cover and Front matter
CJN volume 45 issue 3 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Intracranial Electroencephalographic Monitoring: From Subdural to Depth Electrodes
Intracranial Electroencephalographic Monitoring: From Subdural to Depth Electrodes Open
At the London Health Sciences Centre Epilepsy Program, stereotactically implanted depth electrodes have largely replaced subdural electrodes in the presurgical investigation of patients with drug-resistant epilepsy over the past 4 years. T…
View article: Antiepileptic drugs and hyponatremia in older adults: Two population‐based cohort studies
Antiepileptic drugs and hyponatremia in older adults: Two population‐based cohort studies Open
Summary Objective To examine the 30‐day risk of hospitalization with hyponatremia associated with carbamazepine, valproic acid (V), phenytoin (P), or topiramate (T) use compared to nonuse in the outpatient setting among older adults. Metho…
View article: P.020 Septo-optic dysplasia plus manifesting with medically refractory epilepsy
P.020 Septo-optic dysplasia plus manifesting with medically refractory epilepsy Open
Background: Septo-Optic Dysplasia is a rare disorder with developmental malformations that was first reported by De Morsier.SOD associated with refractory epilepsy has not been well studied. We report six cases with SOD in patients with ma…
View article: Marijuana use in intractable epilepsy
Marijuana use in intractable epilepsy Open
Background: In Canada, marijuana is legal for those with seizures. We determined the prevalence of marijuana use in intractable epilepsy patients and assessed the perceived effects. Methods: Information about marijuana use was collected ov…
View article: CJN volume 42 issue 2 Cover and Front matter
CJN volume 42 issue 2 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Marijuana: A Time-Honored but Untested Treatment for Epilepsy
Marijuana: A Time-Honored but Untested Treatment for Epilepsy Open
The biology of the endocannabinoid system in the brain provides a possible basis for a beneficial pharmacological effect of marijuana on seizures. However, evidence for efficacy of cannabis treatment of epilepsy is anecdotal because no acc…