Scott Sherrill-Mix
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View article: Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021–2024
Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021–2024 Open
SARS-CoV-2 continues to transmit and evolve in humans and animals. White-tailed deer ( Odocoileus virginianus ) have been previously identified as a zoonotic reservoir for SARS-CoV-2 with high rates of infection and probable spillback into…
View article: TET2 regulates early and late transitions in exhausted CD8 <sup>+</sup> T cell differentiation and limits CAR T cell function
TET2 regulates early and late transitions in exhausted CD8 <sup>+</sup> T cell differentiation and limits CAR T cell function Open
CD8 + T cell exhaustion hampers control of cancer and chronic infections and limits chimeric antigen receptor (CAR) T cell efficacy. Targeting TET2 in CAR T cells provides therapeutic benefit; however, TET2’s role in exhausted T cell (T EX…
View article: Post-release survival of loggerhead sea turtles (Caretta caretta) incidentally hooked in a North Atlantic pelagic longline fishery
Post-release survival of loggerhead sea turtles (Caretta caretta) incidentally hooked in a North Atlantic pelagic longline fishery Open
Estimating mortality of sea turtles incidentally captured in fishing gear is essential to understanding fishery impacts on sea turtle populations. Loggerhead turtles ( Caretta caretta ) are a component of bycatch in pelagic longline fisher…
View article: TET2 regulates early and late transitions in exhausted CD8<sup>+</sup>T-cell differentiation and limits CAR T-cell function
TET2 regulates early and late transitions in exhausted CD8<sup>+</sup>T-cell differentiation and limits CAR T-cell function Open
CD8 + T-cell exhaustion hampers disease control in cancer and chronic infections and limits efficacy of T-cell−based therapies, such as CAR T-cells. Epigenetic reprogramming of CAR T-cells by targeting TET2, a methylcytosine dioxygenase th…
View article: Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating
Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating Open
The SARS-CoV-2 pandemic was marked with emerging viral variants, some of which were designated as variants of concern (VOCs) due to selection and rapid circulation in the human population. Here, we elucidate functional features of each VOC…
View article: Virome in immunodeficiency: what we know currently
Virome in immunodeficiency: what we know currently Open
Over the past few years, the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health. Individuals with compromised immune function encounter dis…
View article: Tracking gut microbiome and bloodstream infection in critically ill adults
Tracking gut microbiome and bloodstream infection in critically ill adults Open
Background The gut microbiome is believed to contribute to bloodstream infection (BSI) via translocation of dominant gut bacteria in vulnerable patient populations. However, conclusively linking gut and blood organisms requires stringent a…
View article: Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating
Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating Open
The SARS-CoV-2 pandemic was marked with emerging viral variants, some of which were designated as variants of concern (VOCs) due to selection and rapid circulation in the human population. Here we elucidate functional features of each VOC …
View article: Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study
Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study Open
Background Patients with chronic lymphocytic leukemia (CLL) have reduced seroconversion rates and lower binding antibody (Ab) and neutralizing antibody (NAb) titers than healthy individuals following Severe Acute Respiratory Syndrome Coron…
View article: The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration
The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration Open
Decades of effort have yielded highly effective antiviral agents to treat HIV, but viral strains have evolved resistance to each inhibitor type, focusing attention on the importance of developing new inhibitor classes. A particularly promi…
View article: A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies
A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies Open
An effective HIV-1 vaccination strategy will need to stimulate rare precursor B cells of multiple bNAb lineages and affinity mature them along desired pathways. Here, we searched for V2-apex germ line-targeting Envs among a large set of di…
View article: SARS-CoV-2 mRNA vaccination exposes progressive adaptive immune dysfunction in patients with chronic lymphocytic leukemia
SARS-CoV-2 mRNA vaccination exposes progressive adaptive immune dysfunction in patients with chronic lymphocytic leukemia Open
SUMMARY Chronic lymphocytic leukemia (CLL) patients have lower seroconversion rates and antibody titers following SARS-CoV-2 vaccination, but the reasons for this diminished response are poorly understood. Here, we studied humoral and cell…
View article: A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies
A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies Open
HIV-1 and its SIV precursors share a broadly neutralizing antibody (bNAb) epitope in variable loop 2 (V2) at the envelope glycoprotein (Env) trimer apex. Here, we tested the immunogenicity of germline-targeting versions of a chimpanzee SIV…
View article: Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania
Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania Open
Coronaviruses have been documented to replicate in numerous species of vertebrates, and multiple spillovers of coronaviruses from animals into humans have founded human epidemics. The COVID-19 epidemic likely derived from a spillover of SA…
View article: Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania
Multiple Introductions of SARS-CoV-2 Alpha and Delta Variants into White-Tailed Deer in Pennsylvania Open
Introductory paragraph The SARS-CoV-2 pandemic likely began by viral spillover from animals to humans 1-3 ; today multiple animal species are known to be susceptible to infection 4-8 . White-tailed deer, Odocoileus virginianus are infected…
View article: SARS-CoV-2 Variants Associated with Vaccine Breakthrough in the Delaware Valley through Summer 2021
SARS-CoV-2 Variants Associated with Vaccine Breakthrough in the Delaware Valley through Summer 2021 Open
SARS-CoV-2 vaccination is highly effective at reducing viral infection, hospitalization and death. However, vaccine breakthrough infections have been widely observed, raising the question of whether particular viral variants or viral mutat…
View article: Table S2.docx
Table S2.docx Open
Supplementary Table S2
View article: A Summary of the Sixth International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment
A Summary of the Sixth International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment Open
In October of 2020, researchers from around the world met online for the sixth annual International Workshop on Microbiome in HIV Pathogenesis, Prevention, and Treatment. New research was presented on the roles of the microbiome on immune …
View article: SARS-CoV-2 variants associated with vaccine breakthrough in the Delaware Valley through summer 2021
SARS-CoV-2 variants associated with vaccine breakthrough in the Delaware Valley through summer 2021 Open
The severe acute respiratory coronavirus-2 (SARS-CoV-2) is the cause of the global outbreak of COVID-19. Evidence suggests that the virus is evolving to allow efficient spread through the human population, including vaccinated individuals.…
View article: DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia Open
Red blood cells detect and bind cell-free nucleic acids, contributing to anemia and immune cell activation during acute inflammation.
View article: Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications
Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications Open
As the second year of the COVID-19 pandemic begins, it remains clear that a massive increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to controlling the pandemic and to preparing for future outbr…
View article: Molecular Beacons Allow Specific RT-LAMP Detection of B.1.1.7 Variant SARS-CoV-2
Molecular Beacons Allow Specific RT-LAMP Detection of B.1.1.7 Variant SARS-CoV-2 Open
Over the course of the coronavirus disease 2019 (COVID-19) pandemic, several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic variants of concern have appeared and spread throughout the world. Detection and identificati…
View article: Predictors of Nonseroconversion after SARS-CoV-2 Infection
Predictors of Nonseroconversion after SARS-CoV-2 Infection Open
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2-specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription P…
View article: Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons Open
Background Rapid spread of SARS-CoV-2 has led to a global pandemic, resulting in the need for rapid assays to allow diagnosis and prevention of transmission. Reverse transcription-polymerase chain reaction (RT-PCR) provides a gold standard…
View article: Molecular beacons allow specific RT-LAMP detection of B.1.1.7 variant SARS-CoV-2
Molecular beacons allow specific RT-LAMP detection of B.1.1.7 variant SARS-CoV-2 Open
Over the course of the COVID-19 pandemic, several SARS-CoV-2 genetic variants of concern have appeared and spread throughout the world. Detection and identification of these variants is important to understanding and controlling their rapi…
View article: CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses Open
Significance The CD4 protein of primates has undergone rapid diversification, but the reasons for this remain unknown. Here we show that within-species diversity of the HIV/simian immunodeficiency virus (SIV) envelope (Env) binding (D1) do…
View article: Red Blood Cells Function as DNA Sensors
Red Blood Cells Function as DNA Sensors Open
Erythrocytes have long been mistaken as exclusively inert oxygen carriers lacking immune function. Here we show that red blood cells (RBCs) serve as immune sensors through surface expression of the nucleic acid-sensing toll-like receptor 9…
View article: SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia
SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia Open
Understanding how SARS-CoV-2 spreads globally and within infected individuals is critical to the development of mitigation strategies. We found that most lineages in Philadelphia had resembled sequences from New York, suggesting infection …
View article: Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption Open
Interferon-mediated pressures vary throughout HIV-1 infection but are the highest during viral rebound after treatment interruption.
View article: Additional file 3 of Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons
Additional file 3 of Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons Open
Additional file 3: Table S2. Clinical samples and results of assays for SARS-CoV-2 and human RNA.