Scott P. Orr
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View article: The psychological impact of childbirth: Unscheduled cesarean delivery increases risk for acute stress response
The psychological impact of childbirth: Unscheduled cesarean delivery increases risk for acute stress response Open
Introduction Cesarean delivery is one of the most common surgical procedures in the United States. Despite their frequency and medical necessity, the acute psychological impact of unscheduled cesarean delivery is unknown. This study aimed …
View article: Novel avatar-based video-guided acupuncture imagery treatment for chronic low back pain: a randomised controlled trial in the USA
Novel avatar-based video-guided acupuncture imagery treatment for chronic low back pain: a randomised controlled trial in the USA Open
View article: A 62-Year Follow-Up of Vitallium Cup Arthroplasty: A Case Report and Review of Longevity in Historical Context
A 62-Year Follow-Up of Vitallium Cup Arthroplasty: A Case Report and Review of Longevity in Historical Context Open
View article: REM disruption and REM vagal activity predict extinction recall in trauma-exposed individuals
REM disruption and REM vagal activity predict extinction recall in trauma-exposed individuals Open
Background Accumulating evidence suggests that rapid eye movement sleep (REM) supports the consolidation of extinction memory. REM is disrupted in posttraumatic stress disorder (PTSD), and REM abnormalities after traumatic events increase …
View article: A late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study
A late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study Open
View article: Comparison of autonomic reactivity to trauma and nightmare imagery: A Pilot Study
Comparison of autonomic reactivity to trauma and nightmare imagery: A Pilot Study Open
Study Objectives Trauma-related nightmares (TRNs) are a hallmark symptom of PTSD and are highly correlated with PTSD severity and poor sleep quality. Given the salience and arousal associated with TRNs, they might be an effective target fo…
View article: Establishing the validity of a diagnostic questionnaire for childbirth-related posttraumatic stress disorder: a reply
Establishing the validity of a diagnostic questionnaire for childbirth-related posttraumatic stress disorder: a reply Open
View article: A diagnostic questionnaire for childbirth related posttraumatic stress disorder: a validation study
A diagnostic questionnaire for childbirth related posttraumatic stress disorder: a validation study Open
View article: REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals
REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals Open
Accumulating evidence suggests that rapid eye movement sleep (REM) supports the consolidation of extinction memory. REM is disrupted in PTSD, and REM abnormalities after traumatic events increase the risk of developing PTSD. Therefore, it …
View article: Challenges in Implementing the Mediterranean Diet Identified Through a Food as Medicine Course
Challenges in Implementing the Mediterranean Diet Identified Through a Food as Medicine Course Open
View article: Associations among acute and chronic musculoskeletal pain, sleep duration, and C-reactive protein (CRP): A cross-sectional study of the UK biobank dataset
Associations among acute and chronic musculoskeletal pain, sleep duration, and C-reactive protein (CRP): A cross-sectional study of the UK biobank dataset Open
View article: Exaggerated amygdala activation to ambiguous facial expressions is a familial vulnerability factor for posttraumatic stress disorder
Exaggerated amygdala activation to ambiguous facial expressions is a familial vulnerability factor for posttraumatic stress disorder Open
View article: Response to: “Updated and rectified meta-analysis shows no effect of propranolol versus placebo on traumatic memory reconsolidation disruption”
Response to: “Updated and rectified meta-analysis shows no effect of propranolol versus placebo on traumatic memory reconsolidation disruption” Open
In their letter to the editor, Steenen and colleagues[1][1] argue that the conclusions of our meta-analysis[2][2] on the clinical efficacy of reconsolidation impairment using propranolol are “incorrect in the context of (...) psychotrauma-…
View article: Rapid eye movement sleep parasympathetic activity predicts wake hyperarousal symptoms following a traumatic event
Rapid eye movement sleep parasympathetic activity predicts wake hyperarousal symptoms following a traumatic event Open
Summary Heart rate variability (HRV) can be used to assess changes in output of the parasympathetic nervous system (PNS). Considering that patients with post‐traumatic stress disorder (PTSD) often experience disturbances in sleep, arousal,…
View article: Validation of childbirth-related posttraumatic stress disorder using psychophysiological assessment
Validation of childbirth-related posttraumatic stress disorder using psychophysiological assessment Open
View article: 0673 Script-Driven Imagery in PTSD: Comparing Reactivity to Imagery of Trauma Memories to Imagery of Trauma-Nightmare Memories
0673 Script-Driven Imagery in PTSD: Comparing Reactivity to Imagery of Trauma Memories to Imagery of Trauma-Nightmare Memories Open
Introduction Prolonged Exposure (PE) therapy produces therapeutic fear extinction via imaginal exposure to trauma memories. However, traumatic events that occurred in the distant past and the associated memories may become distorted or hab…
View article: Skin conductance levels and responses in Asian and White participants during fear conditioning✰
Skin conductance levels and responses in Asian and White participants during fear conditioning✰ Open
View article: Randomized controlled experimental study of hydrocortisone and D-cycloserine effects on fear extinction in PTSD
Randomized controlled experimental study of hydrocortisone and D-cycloserine effects on fear extinction in PTSD Open
Fear extinction underlies prolonged exposure, one of the most well-studied treatments for posttraumatic stress disorder (PTSD). There has been increased interest in exploring pharmacological agents to enhance fear extinction learning in hu…
View article: Modulatory Effects of Actual and Imagined Acupuncture on the Functional Connectivity of the Periaqueductal Gray and Ventral Tegmental Area
Modulatory Effects of Actual and Imagined Acupuncture on the Functional Connectivity of the Periaqueductal Gray and Ventral Tegmental Area Open
Objective Both acupuncture and guided imagery hold promise for treating pain. The mechanisms underlying these alternative interventions remain unclear. The reported study aimed to comparatively investigate the modulation effect of actual a…
View article: Autonomic activity, posttraumatic and nontraumatic nightmares, and PTSD after trauma exposure
Autonomic activity, posttraumatic and nontraumatic nightmares, and PTSD after trauma exposure Open
Background Nightmares are a hallmark symptom of posttraumatic stress disorder (PTSD). This strong association may reflect a shared pathophysiology in the form of altered autonomic activity and increased reactivity. Using an acoustic startl…
View article: Interfering with fear memories by eye movement desensitization and reprocessing
Interfering with fear memories by eye movement desensitization and reprocessing Open
View article: Hippocampal circuits underlie improvements in self‐reported anxiety following mindfulness training
Hippocampal circuits underlie improvements in self‐reported anxiety following mindfulness training Open
Introduction Mindfulness meditation has successfully been applied to cultivate skills in self‐regulation of emotion, as it employs the unbiased present moment awareness of experience. This heightened attention to and awareness of sensory e…
View article: Characterizing the analgesic effects of real and imagined acupuncture using functional and structure MRI
Characterizing the analgesic effects of real and imagined acupuncture using functional and structure MRI Open
View article: Imagined and Actual Acupuncture Effects on Chronic Low Back Pain: A Preliminary Study
Imagined and Actual Acupuncture Effects on Chronic Low Back Pain: A Preliminary Study Open
Background . Research suggests that imagined experiences can produce brain responses similar to those produced by actual experiences. Shared brain responses that support both imagination and perception may underlie the functional nature of…
View article: Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABAA and NMDA receptor activity
Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABAA and NMDA receptor activity Open
Several studies have demonstrated poor retention of extinction learning among individuals with posttraumatic stress disorder (PTSD). Gonadal hormone signaling in brain appears to influence the retention of extinction learning differently i…
View article: Baseline Cognitive Performance and Treatment Outcomes From Cognitive-Behavioral Therapies for Posttraumatic Stress Disorder: A Naturalistic Study
Baseline Cognitive Performance and Treatment Outcomes From Cognitive-Behavioral Therapies for Posttraumatic Stress Disorder: A Naturalistic Study Open
These results discourage any notion of excluding patients with PTSD and poorer cognitive ability from CBTs.
View article: Assessing vulnerability to panic: a systematic review of psychological and physiological responses to biological challenges as prospective predictors of panic attacks and panic disorder
Assessing vulnerability to panic: a systematic review of psychological and physiological responses to biological challenges as prospective predictors of panic attacks and panic disorder Open
Background Cognitive–behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat. In a recently developed computational model formalisin…
View article: Influence of intranasal oxytocin on fear consolidation in healthy humans
Influence of intranasal oxytocin on fear consolidation in healthy humans Open
Background Although recent data in healthy humans suggestthat treatment with intranasal oxytocin (OT) may facilitate extinction recall,to date, little is known about the effects of OT on memory consolidationprocesses. Aim To examine the ef…
View article: Strengthened Hippocampal Circuits Underlie Enhanced Retrieval of Extinguished Fear Memories Following Mindfulness Training
Strengthened Hippocampal Circuits Underlie Enhanced Retrieval of Extinguished Fear Memories Following Mindfulness Training Open
View article: Fear extinction learning as a predictor of response to cognitive behavioral therapy for pediatric obsessive compulsive disorder
Fear extinction learning as a predictor of response to cognitive behavioral therapy for pediatric obsessive compulsive disorder Open