Scott Presnell
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View article: Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS
Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS Open
Background Elevated circulating endothelial cells (CECs), released from monolayers after insult, have been implicated in worse outcomes in ARDS and COVID-19, however there is no consensus proteomic phenotype that define CECs. We queried wh…
View article: Longitudinal single cell profiling of epitope specific memory CD4+ T cell responses to recombinant zoster vaccine
Longitudinal single cell profiling of epitope specific memory CD4+ T cell responses to recombinant zoster vaccine Open
View article: IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition Open
View article: Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study Open
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge.…
View article: Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes
Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes Open
Foxp3+ regulatory T cells (Tregs) are critical mediators of peripheral tolerance and immune homeostasis and exert tissue-specific functions. In many nonlymphoid tissues, Tregs show enriched expression of the IL-33 receptor ST2. …
View article: Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study Open
NIH.
View article: Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness Open
Critically ill patients manifest many of the same immune features seen in coronavirus disease 2019 (COVID-19), including both “cytokine storm” and “immune suppression.” However, direct comparisons of molecular and cellular profiles between…
View article: Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data Open
View article: Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children
Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children Open
View article: Endotype of allergic asthma with airway obstruction in urban children
Endotype of allergic asthma with airway obstruction in urban children Open
View article: Airway Epithelial Gene Expression Differs Across Urban Childhood Asthma Phenotypes
Airway Epithelial Gene Expression Differs Across Urban Childhood Asthma Phenotypes Open
View article: Development of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States
Development of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States Open
As the capacity for generating large scale data continues to grow the ability to extract meaningful biological knowledge from it remains a limitation. Here we describe the development of a new fixed repertoire of transcriptional modules. I…
View article: The Influence of MUC5AC SNPs on expression of MUC5AC and mucus hypersecretion genes during asthma exacerbations
The Influence of MUC5AC SNPs on expression of MUC5AC and mucus hypersecretion genes during asthma exacerbations Open
View article: Airway Epithelium Gene Expression Endotyping of Asthma and Airway Obstruction in Urban Children
Airway Epithelium Gene Expression Endotyping of Asthma and Airway Obstruction in Urban Children Open
View article: Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression Open
Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential pro…
View article: A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract
A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract Open
View article: Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children Open
View article: Type-1 Interferon and Th2-Type Gene Expression Responses and Childhood Asthma
Type-1 Interferon and Th2-Type Gene Expression Responses and Childhood Asthma Open
View article: Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States
Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States Open
SUMMARY As the capacity for generating large scale data continues to grow the ability to extract meaningful biological knowledge from it remains a limitation. Here we describe the development of a new fixed repertoire of transcriptional mo…
View article: Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes
Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes Open
Unmasking an agent of inflammatory anemia Infectious and autoimmune diseases are associated with anemia and thrombocytopenia. A severe form of inflammatory cytopenia called macrophage activation syndrome (MAS) may occur during rheumatologi…
View article: Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes Open
View article: A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification Open
The increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opp…
View article: Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response
Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response Open
Malaria remains a major cause of mortality and morbidity worldwide. Progress has been made in recent years with the development of vaccines that could pave the way towards protection of hundreds of millions of exposed individuals. Here we …
View article: A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification Open
The increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opp…
View article: Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria
Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria Open
Identifying molecular predictors and mechanisms of malaria disease is important for understanding how Plasmodium falciparum malaria is controlled. Transcriptomic studies in humans have so far been limited to retrospective analysis of blood…
View article: Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria
Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria Open
Identifying molecular predictors and mechanisms of malaria disease is important for understanding how Plasmodium falciparum malaria is controlled. Transcriptomic studies in humans have so far been limited to retrospective analysis of blood…
View article: A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies
A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies Open
Compendia of large-scale datasets made available in public repositories provide a precious opportunity to discover new biomedical phenomena and to fill gaps in our current knowledge. In order to foster novel insights it is necessary to ens…
View article: A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research
A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research Open
Systems-scale profiling approaches have become widely used in translational research settings. The resulting accumulation of large-scale datasets in public repositories represents a critical opportunity to promote insight and foster knowle…
View article: A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life
A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life Open
Compendia of large-scale datasets made available in public repositories provide an opportunity to identify and fill gaps in biomedical knowledge. But first, these data need to be made readily accessible to research investigators for interp…
View article: A curated transcriptome dataset collection to investigate the immunobiology of HIV infection
A curated transcriptome dataset collection to investigate the immunobiology of HIV infection Open
Compendia of large-scale datasets available in public repositories provide an opportunity to identify and fill current gaps in biomedical knowledge. But first, these data need to be readily accessible to research investigators for interpre…