Explanipedia

Targeted Normoxemia and Supplemental Oxygen–Free Days in Critically Injured Adults Open

David J. Douin, John D. Rice, E. L. Anderson, Conner Jackson, Alex Cheng , et al. · 2025

Importance Supplemental oxygen is fundamental to caring for critically injured adults but can expose them to excess inspired oxygen. Objective To determine the safety and effectiveness of targeting normoxemia in critically ill trauma patie…

The i‐gel® supraglottic airway device compared to endotracheal intubation as the initial prehospital advanced airway device: A natural experiment during the COVID‐19 pandemic Open

Daniel Levi, Joris Hoogendoorn, Shenae Samuels, Lindsay Maguire, Ruben Troncoso , et al. · 2024

In this natural experiment, the SGA performed significantly better than ETI in first-pass airway device placement success and was significantly faster in achieving first-pass success, and overall airway placement, thus potentially reducing…

A voice-based digital assistant for intelligent prompting of evidence-based practices during ICU rounds Open

Andrew J. King, Derek C. Angus, Gregory F. Cooper, Danielle L. Mowery, Jennifer B. Seaman , et al. · 2023

Clindamycin plus Vancomycin versus Linezolid for Treatment of Necrotizing Soft Tissue Infection Open

Joshua Dorazio, Abby L. Chiappelli, Ryan K. Shields, Y Vivian Tsai, Peyton Skinker , et al. · 2023

Background Necrotizing soft tissue infections (NSTIs) are life-threatening infections. The aim of this study is to evaluate the safety of clindamycin plus vancomycin versus linezolid as empiric treatment of NSTI. Methods Retrospective, sin…

Increasing Quality and Frequency of Goals-of-Care Documentation in the Highest-Risk Surgical Candidates Open

Anthony A. Oyekan, Joon Y. Lee, Jacob C. Hodges, Stephen R. Chen, Alan E. Wilson , et al. · 2023

Background: Patient values may be obscured when decisions are made under the circumstances of constrained time and limited counseling. The objective of this study was to determine if a multidisciplinary review aimed at ensuring goal-concor…

Utility of Biomarkers for Sepsis-Associated Acute Kidney Injury Staging Open

Luca Molinari, Gaspar Del Rio‐Pertuz, A.J. Conrad Smith, Douglas Landsittel, Kai Singbartl , et al. · 2022

The findings suggest that assessment of the cell-cycle arrest biomarkers TIMP-2 and IGFBP7 may augment AKI staging for patients with functional criteria for AKI.

Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation Open

Renee R. Anderko, Hernando Gómez, Scott Canna, Bita Shakoory, Derek C. Angus , et al. · 2022

Improving delivery of low tidal volume ventilation in 10 ICUs Open

Chenell Donadee, Mark H Cohen-Melamed, Edgar Delgado, Scott R. Gunn · 2022

Low tidal volume ventilation (LTVV) is standard of care for mechanically ventilated patients with acute respiratory distress syndrome and has been shown to improve outcomes in the general mechanically ventilated population. Despite these i…

The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets Open

Ivan V. Litvinov, Pingxing Xie, Scott R. Gunn, Denis Sasseville, Philippe Lefrançois · 2021

Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. Although most BCCs are easily managed, some are aggressive locally, require Mohs micrographic surgery, or can even metastasize. In the latter, resistance to So…

The ectopic expression of meiCT genes promotes meiomitosis and may facilitate carcinogenesis Open

Jennifer Gantchev, Amelia Martínez Villarreal, Scott R. Gunn, Monique Zetka, N Odum , et al. · 2020

Cancer meiomitosis is defined as the concurrent activation of both mitotic and meiotic machineries in neoplastic cells that confer a selective advantage together with increased genomic instability. MeiCT (meiosis-specific cancer/testis) ge…

In silico analyses of the tumor microenvironment highlight tumoral inflammation, a Th2 cytokine shift and a mesenchymal stem cell-like phenotype in advanced in basal cell carcinomas Open

Philippe Lefrançois, Pingxing Xie, Scott R. Gunn, Jennifer Gantchev, Amelia Martínez Villarreal , et al. · 2020

Basal Cell Carcinoma (BCC) represents the most common form of all cancers. BCC is characteristically surrounded by a fibromyxoid stroma. Previous studies have suggested a shift towards a Th2 response, an increase in T regulatory lymphocyte…

Sepsis-Associated Acute Kidney Disease Open

Sadudee Peerapornratana, Priyanka Priyanka, Shu Wang, A.J. Conrad Smith, Kai Singbartl , et al. · 2020

AKD is common in patients with septic shock, especially among African American males and those with underlying CKD. Existing AKI biomarkers have limited utility for predicting AKD but might be useful together with clinical variables. Novel…

Illness-related suffering and need for palliative care in Rohingya refugees and caregivers in Bangladesh: A cross-sectional study. Open

Megan Doherty, Liam Power, Mila Petrova, Scott R. Gunn, Richard A. Powell , et al. · 2020

BACKGROUND:Despite recognition that palliative care is an essential component of any humanitarian response, serious illness-related suffering continues to be pervasive in these settings. There is very limited evidence about the need for pa…

Illness-related suffering and need for palliative care in Rohingya refugees and caregivers in Bangladesh: A cross-sectional study Open

Megan Doherty, Liam Power, Mila Petrova, Scott R. Gunn, Richard A. Powell , et al. · 2020

Background: Despite recognition that palliative care is an essential component of any humanitarian response, serious illness-related suffering continues to be pervasive in these settings. There is very limited evidence about the need for p…

The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL) Open

Jennifer Gantchev, Amelia Martínez Villarreal, Pingxing Xie, Philippe Lefrançois, Scott R. Gunn , et al. · 2019

Cancer testis (CT) antigens, under normal circumstances are uniquely expressed in testicular germ cells. Recent research has shown that meiosis-specific CT (meiCT) antigens are ectopically expressed in cutaneous T-cell lymphoma (CTCL) and …

Initial absence of N20 waveforms from median nerve somatosensory evoked potentials in a patient with cardiac arrest and good outcomes Open

Miguel Habeych, Pouria Moshayedi, Jon C. Rittenberger, Scott R. Gunn · 2019

A 34-year-old male was brought to the hospital with a chest gunshot wound. Pulseless upon arrival, blood pressure was absent for 10 minutes. A thoracotomy resulted in return of spontaneous circulation. On hospital day 5, with brainstem ref…

Bright environmental light improves the sleepiness of nightshift ICU nurses Open

John E. Griepentrog, Hanna E. Labiner, Scott R. Gunn, Matthew R. Rosengart · 2018

Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness Open

Ajit P. Limaye, Renee D. Stapleton, Lili Peng, Scott R. Gunn, Louise E. Kimball , et al. · 2017

clinicaltrials.gov Identifier: NCT01335932.

Smooth muscle cell responses in in-stent restenosis: the role of necroptosis Open

Scott R. Gunn · 2016

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