Scott S. Terhune
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Gut Microbiota and Cerebrovascular Patterns in Amnestic Mild Cognitive Impairment Open
Background Gut dysbiosis and cerebrovascular disease have both been implicated in Alzheimer's disease (AD) progression and pathophysiology. However, the interplay between them is unclear. The goal of this study was to identify relationship…
View article: HCMV infection of terminally differentiated neurons disrupts microtubule organization, resulting in neurite retraction
HCMV infection of terminally differentiated neurons disrupts microtubule organization, resulting in neurite retraction Open
Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms, including hearing loss, visual …
Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment Open
Background/Objectives: The interplay between the gut microbiome (GMB) and neurovascular function in neurodegeneration is unclear. The goal of this proof-of-concept, cross-sectional study is to identify relationships between the GMB, neurov…
460 Fetal natural killer cells play an essential immunoprotective role in preventing the onset of symptomatic congenital cytomegalovirus Open
Objectives/Goals: Congenital cytomegalovirus (cCMV) continues to be the primary infectious cause of fetal anomalies. The role of fetal natural killer (NK) cells in response to cCMV remains largely unexplored. This study seeks to investigat…
View article: Correction: Maranto et al. Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. Cancers 2020, 12, 3412
Correction: Maranto et al. Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. Cancers 2020, 12, 3412 Open
In the original publication [...]
The effective multiplicity of infection for HCMV depends on the activity of the cellular 20S proteasome Open
Human cytomegalovirus (HCMV) is a betaherpesvirus capable of infecting numerous cell types and persisting throughout an infected individual’s life. Disease usually occurs in individuals with compromised or underdeveloped immune systems. Se…
Memory NKG2C+ nk Cells Undergo Robust Expansion and Exhibit Strong Effector Functions upon Re-Exposure to the HCMV gpUL40 Antigen Peptide Open
Background: Natural Killer (NK) cells play a crucial role in the immediate immune response against virally infected and transformed cells. Managing human cytomegalovirus (HCMV) infections relies on a subset of NKG2C+ NK cells. The NKG2C/CD…
The effective multiplicity of infection for HCMV depends on activity of the cellular 20S proteasome Open
Human cytomegalovirus (HCMV) is a betaherpesvirus capable of infecting numerous cell types and persisting throughout an infected individual’s life. Disease usually occurs in individuals with compromised or underdeveloped immune systems. Se…
View article: Stabilizing microtubules aids neurite structure and disrupts syncytia formation in human cytomegalovirus-infected human forebrain neurons
Stabilizing microtubules aids neurite structure and disrupts syncytia formation in human cytomegalovirus-infected human forebrain neurons Open
Human cytomegalovirus (HCMV) is a prolific human herpesvirus that infects most individuals by adulthood. While typically asymptomatic in adults, congenital infection can induce serious neurological symptoms including hearing loss, visual d…
379 Characterizing the single-cell transcriptomes of fetal natural killer cells isolated from the umbilical cord of fetuses exposed to human cytomegalovirus during gestation Open
OBJECTIVES/GOALS: Congenital cytomegalovirus (cCMV) remains to be the leading infectious cause of fetal anomalies. The role of fetal natural killer (NK) cells during cCMV remains largely unknown. The objective of this study is to define th…
Replication efficiencies of human cytomegalovirus-infected epithelial cells are dependent on source of virus production Open
Human cytomegalovirus (HCMV) is a prevalent betaherpesvirus, and infection can lead to a range of symptomatology from mononucleosis to sepsis in immunocompromised individuals. HCMV is also the leading viral cause of congenital birth defect…
View article: Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy
Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy Open
Since the FDA’s approval of chimeric antigen receptor (CAR) T cells in 2017, significant improvements have been made in the design of chimeric antigen receptor constructs and in the manufacturing of CAR T cell therapies resulting in increa…
BioModME for building and simulating dynamic computational models of complex biological systems Open
Summary Molecular mechanisms of biological functions and disease processes are exceptionally complex, and our ability to interrogate and understand relationships is becoming increasingly dependent on the use of computational modeling. We h…
View article: Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons
Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons Open
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency. However, in 10%–15% of congenital cases, this beta-herpesvirus demonstrates direct …
View article: Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus
Neutralizing antibodies with neurotropic factor treatment maintain neurodevelopmental gene expression upon exposure to human cytomegalovirus Open
Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Entry of HCMV into human cells is determined by the composition of glycoproteins in viral…
Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection Open
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defi…
Single cell transcriptomes from HCMV+ donors reveal a unique NKG2CHigh subset that represents true memory NK cells Open
Infection with human cytomegalovirus (HCMV) can result in severe morbidity and mortality to the developing fetus and immunocompromised individuals. Natural killer (NK) cells are cytotoxic lymphocytes that are required to manage and control…
267 Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection Open
OBJECTIVES/GOALS: The primary objective of this study was to define the transcriptomes and transcriptional regulatory network required for the development and function of adaptive Natural Killer (NK) cells in donors with latent human cytom…
View article: Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons
Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons Open
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency. However, in 10-15% of congenital cases, this beta-herpesvirus demonstrates direct e…
View article: Neutralizing Antibodies with Neurotropic Factor Treatment Maintain Neurodevelopmental Gene Expression Upon Exposure to Human Cytomegalovirus
Neutralizing Antibodies with Neurotropic Factor Treatment Maintain Neurodevelopmental Gene Expression Upon Exposure to Human Cytomegalovirus Open
Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Infection of cerebral organoids with HCMV causes significant downregulation of genes invo…
View article: Simulating the Evolution of Signaling Signatures during CART-Cell - Tumor Cell Interactions.
Simulating the Evolution of Signaling Signatures during CART-Cell - Tumor Cell Interactions. Open
Immunotherapies have been proven to have significant therapeutic efficacy in the treatment of cancer. The last decade has seen adoptive cell therapies, such as chimeric antigen receptor T-cell (CART-cell) therapy, gain FDA approval against…
View article: Simulating the Evolution of Signaling Signatures during CART-Cell -- Tumor Cell Interactions
Simulating the Evolution of Signaling Signatures during CART-Cell -- Tumor Cell Interactions Open
Immunotherapies have been proven to have significant therapeutic efficacy in the treatment of cancer. The last decade has seen adoptive cell therapies, such as chimeric antigen receptor T-cell (CART-cell) therapy, gain FDA approval against…
Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection Open
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defi…
View article: Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in Ori <i>Lyt</i>
Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in Ori <i>Lyt</i> Open
HCMV is an important human pathogen associated with complications in transplant patients and birth defects. The complex program of viral gene expression is regulated by both viral proteins and host factors.
Computational modeling of protracted HCMV replication using genome substrates and protein temporal profiles Open
Human cytomegalovirus (HCMV) is a major cause of illness in immunocompromised individuals. The HCMV lytic cycle contributes to the clinical manifestations of infection. The lytic cycle occurs over ∼96 h in diverse cell types and consists o…
View article: Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization
Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization Open
Human cytomegalovirus (HCMV) is the leading cause of virus-mediated congenital birth defects. Congenitally infected infants can have a variety of symptoms manifesting within the central nervous system.
Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function Open
Significance Until now, it was not known if, how, or why pathogenic human viruses might modulate the de novo production of the replication-dependent (RD) histone proteins that decorate their DNA genomes within infected cells. Our finding t…