Gregory S. Schultz
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View article: Assessment of the quality and safety of fast food sold on the streets of the Benfica Urban District, Angola
Assessment of the quality and safety of fast food sold on the streets of the Benfica Urban District, Angola Open
Food is a fundamental necessity for any society, as it directly influences the population's quality of life and is associated with the maintenance, prevention, and recovery of health. This study aims to assess the microbiological quality a…
View article: Association of biofilm and microbial metrics with healing rate in older adults with chronic venous leg ulcers
Association of biofilm and microbial metrics with healing rate in older adults with chronic venous leg ulcers Open
The presence of microbial biofilms in many human chronic wounds led to the hypothesis that biofilms delay healing of these wounds. We tested this hypothesis in a population of 117 older individuals with venous leg ulcers who were receiving…
View article: What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing
What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing Open
Slough is a well‐known feature of non‐healing wounds. This pilot study aims to determine the proteomic and microbiologic components of slough as well as interrogate the associations between wound slough components and wound healing. Ten su…
View article: What is Slough? A pilot study to define the proteomic and microbial composition of wound slough and its implications for wound healing
What is Slough? A pilot study to define the proteomic and microbial composition of wound slough and its implications for wound healing Open
Slough is a well-known feature of non-healing wounds. This study aims to determine the proteomic and microbiologic components of slough as well as interrogate the associations between wound slough components and wound healing. Twenty-three…
View article: Chronic wounds: Treatment consensus
Chronic wounds: Treatment consensus Open
The Wound Healing Foundation (WHF) recognised a need for an unbiased consensus on the best treatment of chronic wounds. A panel of 13 experts were invited to a virtual meeting which took place on 27 March 2021. The proceedings were organis…
View article: Accrual and retention of diverse patients in psychosocial cancer clinical trials
Accrual and retention of diverse patients in psychosocial cancer clinical trials Open
Background: Minority and older adult patients remain underrepresented in cancer clinical trials (CCTs). The current study sought to examine sociodemographic inequities in CCT interest, eligibility, enrollment, decline motivation, and attri…
View article: Are Semi-Quantitative Clinical Cultures Inadequate? Comparison to Quantitative Analysis of 1053 Bacterial Isolates from 350 Wounds
Are Semi-Quantitative Clinical Cultures Inadequate? Comparison to Quantitative Analysis of 1053 Bacterial Isolates from 350 Wounds Open
Early awareness and management of bacterial burden and biofilm is essential to wound healing. Semi-quantitative analysis of swab or biopsy samples is a relatively simple method for measuring wound microbial load. The accuracy of semi-quant…
View article: Impacts of Cognitive Behavioral Therapy for Insomnia and Pain on Sleep in Women with Gynecologic Malignancies: A Randomized Controlled Trial
Impacts of Cognitive Behavioral Therapy for Insomnia and Pain on Sleep in Women with Gynecologic Malignancies: A Randomized Controlled Trial Open
Insomnia is an adverse cancer outcome impacting mood, pain, quality of life, and mortality in cancer patients. Cognitive Behavioral Therapy (CBT) is an evidence-based treatment for diverse psychophysiological disorders, including pain and …
View article: Topical doxycycline monohydrate hydrogel 1% targeting proteases/PAR2 pathway is a novel therapeutic for atopic dermatitis
Topical doxycycline monohydrate hydrogel 1% targeting proteases/PAR2 pathway is a novel therapeutic for atopic dermatitis Open
Atopic Dermatitis (AD) is characterized by skin barrier disruption and an aberrant immune response. Doxycycline is tetracycline antibiotics broadly used systemically to treat inflammatory dermatologic conditions. Several studies have shown…
View article: Diagnosis and Management of Diabetic Foot Infections
Diagnosis and Management of Diabetic Foot Infections Open
The first sections herein cover the impact of infection on healing of experimental wounds (p. 2), the importance of biofilms (p. 4), and a general overview of the microbiology of DFIs (p. 6). Although debridement of DFUs was covered in the…
View article: Rapid detection of biofilm by wound blotting following sharp debridement of chronic pressure ulcers predicts wound healing: A preliminary study
Rapid detection of biofilm by wound blotting following sharp debridement of chronic pressure ulcers predicts wound healing: A preliminary study Open
For optimal wound bed preparation, wound debridement is essential to eliminate bacterial biofilms. However, it is challenging for clinicians to determine whether the biofilm is completely removed. A newly developed biofilm detection method…
View article: Interleukin-6 and body mass index, tobacco use, and sleep in gynecologic cancers.
Interleukin-6 and body mass index, tobacco use, and sleep in gynecologic cancers. Open
Higher BMI and any history of tobacco use predicted higher IL-6 among women undergoing surgery for suspected gynecologic cancers. Cognitive-behavioral interventions targeting primary and secondary obesity and tobacco use prevention may red…
View article: Biobehavioral Mechanisms Associated With Nonhealing Wounds and Psychoneurologic Symptoms (Pain, Cognitive Dysfunction, Fatigue, Depression, and Anxiety) in Older Individuals With Chronic Venous Leg Ulcers
Biobehavioral Mechanisms Associated With Nonhealing Wounds and Psychoneurologic Symptoms (Pain, Cognitive Dysfunction, Fatigue, Depression, and Anxiety) in Older Individuals With Chronic Venous Leg Ulcers Open
The prevalence and incidence of chronic venous leg ulcers (CVLUs) are increasing worldwide, as are the associated financial costs. Although it has long been known that their underlying etiology is venous insufficiency, the molecular aspect…
View article: Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo
Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo Open
Biofilms are prevalent in non‐healing chronic wounds and implicated in delayed healing. Tolerance to antimicrobial treatments and the host's immune system leave clinicians with limited interventions against biofilm populations. It is there…
View article: Implementing TIMERS: the race against hard-to-heal wounds
Implementing TIMERS: the race against hard-to-heal wounds Open
Analizar los costos y la efectividad del uso de sistemas de presión negativa comparado con sistemas de oxigenoterapia tópica y nepidermina en el tratamiento de las úlceras de pie diabético en Colombia
View article: Modulating Ocular Scarring in Glaucoma Filtration Surgery Using the Epigenetic Adjunct Suberoylanilide Hydroxamic Acid
Modulating Ocular Scarring in Glaucoma Filtration Surgery Using the Epigenetic Adjunct Suberoylanilide Hydroxamic Acid Open
Rodgers CD, Lukowski ZL, et al. Modulating Ocular Scarring in Glaucoma Filtration Surgery Using the Epigenetic Adjunct Suberoylanilide Hydroxamic Acid. J Curr Glaucoma Pract 2019;13(1):37-41.
View article: Capillary alginate gel (Capgel™) for the treatment of full-thickness dermal wounds in a hypoxic mouse model
Capillary alginate gel (Capgel™) for the treatment of full-thickness dermal wounds in a hypoxic mouse model Open
In this study, capillary alginate gel (Capgel™), a collagen and alginate based self-assembling biomaterial, was used as a cellular scaffold for the treatment of ischemic, full-thickness dermal wounds in mice. Capgel™ was synthesized using …
View article: Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (<scp>SHSA</scp>) 2017
Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (<span>SHSA</span>) 2017 Open
The 2nd Annual Symposium on Hidradenitis Suppurativa Advances ( SHSA ) took place on 03‐05 November 2017 in Detroit, Michigan, USA . This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation ( HSF Inc.) founded in the U…
View article: Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model
Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model Open
Stromal-wounded ex vivo canine corneas exhibited greater optical clarity when treated with SAHA and pirfenidone than when placebo treated at 21 days. There was no significant difference in epithelialization rate between groups. Corneal con…
View article: Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature
Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature Open
Hidradenitis suppurativa (HS) is a chronic skin disease of the pilo-sebaceous apocrine unit characterized by significant inflammation and an impaired quality of life. The pathogenesis of HS remains unclear. To determine the HS skin and blo…
View article: <i>In Vivo</i> Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
<i>In Vivo</i> Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency Open
Herpes simplex virus (HSV) establishes a lifelong infection and remains dormant (latent) in our nerve cells. Occasionally HSV reactivates to cause disease, with HSV-1 typically causing cold sores whereas HSV-2 is the most common cause of g…
View article: Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers
Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers Open
Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi‐factorial nature of the disease, which may include…
View article: Oxidized Regenerated Cellulose/Collagen Dressings: Review of Evidence and Recommendations
Oxidized Regenerated Cellulose/Collagen Dressings: Review of Evidence and Recommendations Open
OBJECTIVE: Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose…
View article: Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo
Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo Open
Short durations of exposure to topical antimicrobial wound solutions commonly utilized by clinicians are ineffective against microbial biofilms, particularly when used in vivo. Wound solutions should not be used as a sole therapy and clini…
View article: Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds Open
Background: Despite a growing consensus that biofilms contribute to a delay in the healing of chronic wounds, conflicting evidence pertaining to their identification and management can lead to uncertainty regarding treatment. This, in part…