Scott Varney YOU? Author Swipe

Last 10y

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models Open

Connor A. Ott, Timothy J. Purwin, Panyu Chen, Somenath Chowdhury, George L. Mellor , et al. · 2025

Targeted therapies in cancer are limited by cells exhibiting drug tolerance. We aimed to target drug tolerance in order to delay the development of acquired resistance. In melanoma, tolerance to MAPK pathway inhibitors is associated with l…

Figure S1 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open

Scott Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua , et al. · 2025

Figure S1. GSDMD cleavage fragments induced by Etomoxir.

Data from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open

Scott Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua , et al. · 2025

Few treatment options are available for patients with metastatic uveal melanoma. Although the bispecific tebentafusp is FDA approved, immunotherapy has largely failed, likely given the poorly immunogenic nature of uveal melanoma. Treatment…

Figure S2 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open

Scott Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua , et al. · 2025

Figure S2. CPT1A ‘activity-signature’ score (GSVA) K-Means clustering and association with SCNA clusters in TCGA-UVM data.

Table S1 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open

Scott Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua , et al. · 2025

Table S1. PScore and CPT1A ‘activity’ signature gene sets.

Table S2 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open

Scott Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua , et al. · 2025

Table S2. UM patient ICb treatment groups in figure 7.

Figure S3 from Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma Open

Scott Varney, Dan A. Erkes, Glenn L. Mersky, Manal U. Mustafa, Vivian Chua , et al. · 2025

Figure S3. Etomoxir-induced, pyroptotic DAMP release does not require GSDMD.

Regulation of myoepithelial differentiation Open

Renée F. Thiemann, Scott Varney, Nicholas Moskwa, John M. Lamar, Melinda Larsen , et al. · 2022

The salivary gland can be permanently impaired by radiation treatment for head and neck cancers. Efforts at tissue regeneration have focused on saliva-producing acinar cells. However, myoepithelial cells are also critical to gland function…

Loss of Integrin α9β1 on Tumor Keratinocytes Enhances the Stromal Vasculature and Growth of Cutaneous Tumors Open

Scott Varney, Lei Wu, Whitney Longmate, C. Michael DiPersio, Livingston Van De Water · 2021

Regulation of Myoepithelial Differentiation in 3-Dimensional Culture Open

Renée F. Thiemann, Scott Varney, Nicholas Moskwa, John M. Lamar, Melinda Larsen , et al. · 2021

The salivary gland can be permanently impaired by radiation treatment for head and neck cancers. Efforts at tissue regeneration have focused on saliva-producing acinar cells. However, myoepithelial cells are also critical to gland function…

Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity Open

Jennifer L. Yates, Dylan Ehrbar, Danielle Hunt, Roxie C. Girardin, Alan P. Dupuis , et al. · 2021

Integrin α4β1 is required for <span>IL</span>‐1α‐ and Nrf2‐dependent, Cox‐2 induction in fibroblasts, supporting a mechanism that suppresses <span>α‐SMA</span> expression Open

Rui Zheng, Scott Varney, Lei Wu, C. Michael DiPersio, Livingston Van De Water · 2021

Growth and repair processes, both normal and pathological, require reciprocal interactions between cells and their microenvironment. Integrins are bidirectional, cell surface receptors that transduce mechanical and chemical signals to and …

Serological Analysis Reveals an Imbalanced IgG Subclass Composition Associated with COVID-19 Disease Severity Open

Jennifer L. Yates, Dylan Ehrbar, Danielle Hunt, Roxie C. Girardin, Alan P. Dupuis , et al. · 2020

Summary COVID-19 is associated with a wide spectrum of disease severity, ranging from asymptomatic to acute respiratory distress syndrome (ARDS). Paradoxically, a direct relationship has been suggested between COVID-19 disease severity, an…

Integrin α3β1 on Tumor Keratinocytes Is Essential to Maintain Tumor Growth and Promotes a Tumor-Supportive Keratinocyte Secretome Open

Whitney Longmate, Scott Varney, Derek Power, Rakshitha Pandulal Miskin, Karl E. Anderson , et al. · 2020

Watching sitcoms together: a discursive analysis Open

Scott Varney · 2020

In this thesis I use conversation analytic (CA) and discursive psychological (DP) principles to examine the ways in which groups of people watch situation comedy shows (sitcoms) together. More specifically, this thesis addresses three aims…

Keratinocyte Integrin α3β1 Promotes Secretion of IL-1α to Effect Paracrine Regulation of Fibroblast Gene Expression and Differentiation Open

Rui Zheng, Whitney Longmate, Lori DeFreest, Scott Varney, Lei Wu , et al. · 2019

Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation Open

Scott Varney, Courtney B. Betts, Rui Zheng, Lei Wu, Boris Hinz , et al. · 2016

How mechanical cues from the extracellular environment are translated biochemically to modulate the effects of TGF-β on myofibroblast differentiation remains a critical area of investigation. We report here that the focal adhesion protein,…

Matrix compliance and the regulation of cytokinesis Open

Savitha Sambandamoorthy, Shomita S. Mathew‐Steiner, Scott Varney, Jonathan M. Zuidema, Ryan J. Gilbert , et al. · 2015

Integrin-mediated cell adhesion to the ECM regulates many physiological processes in part by controlling cell proliferation. It is well established that many normal cells require integrin-mediated adhesion to enter S phase of the cell cycl…

Fetching topic information...