Scott W. Burchiel
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View article: Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults
Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults Open
There is limited evidence on the effects of environmental exposure to arsenic (As) on the immune system in adults. In a population-based study, we have found that urinary As (UAs), and its metabolites [inorganic As (InAs), monomethylated a…
View article: Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity
Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity Open
Particulate matter (PM) presents an environmental health risk for communities residing close to uranium (U) mine sites. However, the role of the particulate form of U on its cellular toxicity is still poorly understood. Here, we investigat…
View article: Arsenic exposure, Vit D, Th17 cells and IL17A cytokine Data Set
Arsenic exposure, Vit D, Th17 cells and IL17A cytokine Data Set Open
Blood and urine samples collected from men and women both smokers and non-smokers. Peripheral blood mononuclear cells were isolated and assayed for presence of Th17 cells (flow cytometry) and IL-17A cytokine production (ELISA). Urinary ars…
View article: Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women
Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women Open
There are limited data examining the consequences of environmental exposure to arsenic on the immune system in adults, particularly among smokers. Smoking has been shown to exacerbate or contribute to impaired immune function in men chroni…
View article: Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite
Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite Open
It is known in humans and mouse models, that drinking water exposures to arsenite (As+3) leads to immunotoxicity. Previously, our group showed that certain types of immune cells are extremely sensitive to arsenic induced genotoxicity. In o…
View article: Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women
Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women Open
This is a dataset of 614 men and women. Included are age (year), Smoking status (never smoker/eversmoker), BMI, proliferation in counts per minute following stimulation with mitogens: CD3CD28 or PHA or No Mito, arsenic exposure and metablo…
View article: Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women
Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women Open
This is a dataset of 614 men and women. Included are age (year), Smoking status (never smoker/eversmoker), BMI, proliferation in counts per minute following stimulation with mitogens: CD3CD28 or PHA or No Mito, arsenic exposure and metablo…
View article: Arsenic exposure, lung function, vitamin D and immune modulation in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort
Arsenic exposure, lung function, vitamin D and immune modulation in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort Open
Epidemiologic research, including our own, has demonstrated associations of arsenic (As) exposure with impaired lung function. While an overwhelming number of recent reports demonstrates a protective role of vitamin D (vit. D) on the respi…
View article: Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort
Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort Open
Exposures to environmental arsenic (As) and polycyclic aromatic hydrocarbons (PAH) have been shown to independently cause dysregulation of immune function. Little data exists on the associations between combined exposures to As and PAH wit…
View article: Assessment of arsenic and polycyclic aromatic hydrocarbon (PAH) exposures on immune function among males in Bangladesh
Assessment of arsenic and polycyclic aromatic hydrocarbon (PAH) exposures on immune function among males in Bangladesh Open
Arsenic and polycyclic aromatic hydrocarbons (PAH) are environmental pollutants to which people around the world are exposed through water, food and air. In mouse and in vitro studies of human cells, both of these chemicals have been shown…
View article: Cerium Levels in Coarse and Fine Airborne Particulate Matter in El Paso, Texas, U.S.A.
Cerium Levels in Coarse and Fine Airborne Particulate Matter in El Paso, Texas, U.S.A. Open
In Europe, ceria or cerium dioxide (CeO2), introduced into diesel road fuel as nanoparticles, has significantly reduced emissions as well as increased vehicle mileage. Concerns have been raised there about the fate and potential health ris…
View article: Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort
Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort Open
198 male study participants with urinary arsenic and PAH-adduct measurments. With cell surface marker and Th cell subset data. Also includes water arsenic exposure, age, smoking status and BMI.
View article: Arsenic PAH Immune Function.xlsx
Arsenic PAH Immune Function.xlsx Open
Data is from a male Bangladeshi cohort exposed environmental arsenic and PAHs. Immune function testing (T cell mitogenesis and cytokine production) were measured in isolated peripheral blood mononuclear cells which had been cryopreserved.
View article: Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice
Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice Open
High levels of uranium (U) exist in soil, water, and air in the Southwestern United States due, in part, to waste generated from more than 160,000 abandoned hard rock mines located in this region. As a result, many people living in this re…
View article: Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data. Following a 60-day Drinking Water Exposure to 5 and 50 ppm Uranium (uranyl acetate).
Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data. Following a 60-day Drinking Water Exposure to 5 and 50 ppm Uranium (uranyl acetate). Open
Male and Female C57BL/6J Mice, Tissue Uranium ICP/MS and Water intake data for mice exposed to uranium for 60-days (uranyl acetate).Bolt AM. et. al. Title of Manuscript: Minimal uranium accumulation in lymphoid tissues following an oral 60…
View article: Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data. Following a 60-day Drinking Water Exposure to 5 and 50 ppm Uranium (uranyl acetate).
Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data. Following a 60-day Drinking Water Exposure to 5 and 50 ppm Uranium (uranyl acetate). Open
Male and Female C57BL/6J Mice, Tissue Uranium ICP/MS and Water intake data for mice exposed to uranium for 60-days (uranyl acetate).Bolt AM. et. al. Title of Manuscript: Minimal uranium accumulation in lymphoid tissues following an oral 60…
View article: Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data
Male and Female Mice Uranium Tissue ICP/MS and Water Intake Data Open
Male and Female C57BL/6J Mice, Tissue Uranium ICP/MS and Water intake data for mice exposed to uranium for 60-days
View article: Isolation, Cryopreservation, and Immunophenotyping of Human Peripheral Blood Mononuclear Cells
Isolation, Cryopreservation, and Immunophenotyping of Human Peripheral Blood Mononuclear Cells Open
This unit describes procedures for the isolation, cryopreservation, and thawing of human peripheral blood mononuclear cells (HPBMC) and analysis of cell surface markers (CSM) for immunophenotyping using polychromatic flow cytometry. This m…
View article: Intracellular Cytokine Detection by Flow Cytometry in Surface Marker‐Defined Human Peripheral Blood Mononuclear T Cells
Intracellular Cytokine Detection by Flow Cytometry in Surface Marker‐Defined Human Peripheral Blood Mononuclear T Cells Open
In a recent unit in this series, protocols for the isolation, cryopreservation, thawing, and immunophenotyping of HPBMC isolated from peripheral whole blood using cell surface marker (CSM) staining and multi‐color flow cytometry analysis w…