Scott W. McPherson
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View article: Serum zinc level independently predicts need for inpatient intubation among patients hospitalized with COVID‐19: A prospective observational study
Serum zinc level independently predicts need for inpatient intubation among patients hospitalized with COVID‐19: A prospective observational study Open
Background The coronavirus disease 2019 (COVID‐19) pandemic caused significant morbidity and mortality. Further study of modifiable factors influencing COVID‐19 severity and outcomes continues to be necessary. Serum zinc levels may play a …
View article: C1q limits cystoid edema by maintaining basal β-catenin–dependent signaling and blood-retina barrier function
C1q limits cystoid edema by maintaining basal β-catenin–dependent signaling and blood-retina barrier function Open
Macular edema (ME) can cause profound vision impairment and occurs in several prevalent retinal diseases, including diabetic retinopathy, choroidal neovascularization, retinal vein occlusion, and uveitis. Retinal edema typically results fr…
View article: The Role of Retinal Antigen-Presenting Cells in Spontaneous Retinal Autoimmunity
The Role of Retinal Antigen-Presenting Cells in Spontaneous Retinal Autoimmunity Open
Our observations that local depletion of retinal APCs failed to inhibit SAU progression and that depletion of circulating APCs not only limited SAU progression but also, under defined circumstances, reduced clinical SAU support the idea th…
View article: Rescue of the Stargardt Disease Phenotype in <scp> <i>Abca4</i> </scp> Knockout Mice Through Dietary Modulation of the Vitamin A Receptor <scp>RBPR2</scp>
Rescue of the Stargardt Disease Phenotype in <span> <i>Abca4</i> </span> Knockout Mice Through Dietary Modulation of the Vitamin A Receptor <span>RBPR2</span> Open
Mutations in the ABCA4 gene in Stargardt disease (STGD1) cause enhanced accumulation of cytotoxic lipofuscin, manifesting in RPE atrophy and photoreceptor dysfunction. One component of lipofuscin is the all‐ trans ‐retinal derivative, pyri…
View article: C1q limits cystoid edema by maintaining basal beta-catenin-dependent signaling and blood-retina barrier function
C1q limits cystoid edema by maintaining basal beta-catenin-dependent signaling and blood-retina barrier function Open
Macular edema (ME) causes significant vision impairment and occurs in several prevalent retinal diseases including diabetic retinopathy (DR), choroidal neovascularization (CNV), retinal vein occlusion, and uveitis. Retinal edema typically …
View article: Rescue of the Stargardt Disease phenotype in <i>Abca4</i> knockout mice through dietary modulation of the vitamin A receptor RBPR2
Rescue of the Stargardt Disease phenotype in <i>Abca4</i> knockout mice through dietary modulation of the vitamin A receptor RBPR2 Open
Mutations in the ABCA4 gene in Stargardt disease (STGD1) causes accumulation of cytotoxic lipofuscin, resulting in RPE atrophy and photoreceptor dysfunction. One component of lipofuscin is the all- trans -retinal derivative, bisretinoid N-…
View article: Safety of integrated mass drug administration of azithromycin, albendazole and ivermectin versus standard treatment regimens: a cluster-randomised trial in Ethiopia
Safety of integrated mass drug administration of azithromycin, albendazole and ivermectin versus standard treatment regimens: a cluster-randomised trial in Ethiopia Open
View article: Improving the distribution and uptake of medicines: lessons from the global trachoma programme.
Improving the distribution and uptake of medicines: lessons from the global trachoma programme. Open
View article: Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis
Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis Open
Background Characterizing immune cells and conditions that govern their recruitment and function in autoimmune diseases of the nervous system or in neurodegenerative processes is an area of active investigation. We sought to analyze the or…
View article: Recruitment of circulating antigen presenting cells to the retina is necessary for induction of autoimmune retinitis
Recruitment of circulating antigen presenting cells to the retina is necessary for induction of autoimmune retinitis Open
Background Characterizing immune cells and conditions that govern their recruitment and function in autoimmune diseases of the nervous system or in neurodegenerative processes is an area of active investigation. We sought to analyze the or…
View article: Innovative tools to advance trachoma elimination in the context of COVID-19.
Innovative tools to advance trachoma elimination in the context of COVID-19. Open
View article: Investigate Oral Zinc as a Prophylactic Treatment for Those at Risk for COVID-19
Investigate Oral Zinc as a Prophylactic Treatment for Those at Risk for COVID-19 Open
View article: Parabiosis Shows That Interplay of Donor Effector and Regulatory T cells Influences the Outcome of Disease Induction in the Partner Mouse.
Parabiosis Shows That Interplay of Donor Effector and Regulatory T cells Influences the Outcome of Disease Induction in the Partner Mouse. Open
View article: The retinal environment induces microglia-like properties in recruited myeloid cells
The retinal environment induces microglia-like properties in recruited myeloid cells Open
View article: Additional file 1: of The retinal environment induces microglia-like properties in recruited myeloid cells
Additional file 1: of The retinal environment induces microglia-like properties in recruited myeloid cells Open
Figure S1 Confocal microscopy of GFP and YFP expression in retinas from CD11c and/or CX3CR1 promoters in transgenic mice. (A) GFPhi cells present in the outer plexiform layer of naïve CD11cDTR/GFP retina. (B) Detection of YFPhi cells in th…
View article: Additional file 2: of The retinal environment induces microglia-like properties in recruited myeloid cells
Additional file 2: of The retinal environment induces microglia-like properties in recruited myeloid cells Open
Figure S2 Analysis of retinas for local progenitors following ONC. (A) Transient appearance of CD34+ cells in the retinas of non-ablated, non-chimeric CD11cDTR/GFP mice after ONC. CD34+ cell numbers (mean ± SD, n = 4) were determined by di…
View article: Optic nerve as a source of activated retinal microglia post-injury
Optic nerve as a source of activated retinal microglia post-injury Open
Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter we found that a controlled optic nerve crush (ONC) injury attracted GFPhi retinal myeloid cells to the dying retinal ganglion cells and their…
View article: Replacement of retinal microglia with donor bone marrow-derived macrophages yields microglia-like cells
Replacement of retinal microglia with donor bone marrow-derived macrophages yields microglia-like cells Open
View article: Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue with New Zinc Detecting Probes
Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue with New Zinc Detecting Probes Open
View article: Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis).
Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis). Open
Detection of sub-RPE deposits by ZPP1 was greatly enhanced compared to Zinpyr-1. This enhanced sensitivity will allow for more insightful analysis of zinc in AMD using human specimens and mouse models. This could result in the development …
View article: Analysis of Factors Necessary for Recruitment and Retention of Mononuclear Cells in the Retina
Analysis of Factors Necessary for Recruitment and Retention of Mononuclear Cells in the Retina Open
View article: Optic Nerve as a Source of Retinal Mononuclear Cells Post-Injury
Optic Nerve as a Source of Retinal Mononuclear Cells Post-Injury Open
View article: Recruited mononuclear cells can occupy the retinal microglia niche
Recruited mononuclear cells can occupy the retinal microglia niche Open
View article: The Retinal Environment Controls the Transcription Pattern of Resident and Recruited Mononuclear Cells
The Retinal Environment Controls the Transcription Pattern of Resident and Recruited Mononuclear Cells Open