Scott Waddell
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View article: Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite
Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite Open
Nutrient state shapes not only what animals eat, but how they eat it. We lack circuit-level mechanisms explaining how gustatory and internal state information regulates feeding at the motor control level. In Drosophila , protein deprivatio…
View article: A modulatory attentional gate promotes recent memory expression in Drosophila
A modulatory attentional gate promotes recent memory expression in Drosophila Open
Using short-term memory (STM) requires that animals can distinguish memories of recent experience from those learned previously. In Drosophila the neuromodulator octopamine (OA) specifically affects STM through adrenergic-like receptors wi…
View article: Twists to Classical Conditioning of Adult<i>Drosophila</i>
Twists to Classical Conditioning of Adult<i>Drosophila</i> Open
Memory has been extensively studied in Drosophila since the early 1970s. Straightforward aversive and appetitive conditioning paradigms train populations of flies to associate the pairing of one of two odors with either punishment or rewar…
View article: Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila
Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila Open
Hungry animals need compensatory mechanisms to maintain flexible brain function, while modulation reconfigures circuits to prioritize resource seeking. In Drosophila, hunger inhibits aversively reinforcing dopaminergic neurons (DANs) to pe…
View article: Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration Open
Summary Parkinson’s disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and Drosophil…
View article: Multisensory learning binds neurons into a cross-modal memory engram
Multisensory learning binds neurons into a cross-modal memory engram Open
Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory …
View article: Multisensory learning binds modality-specific neurons into a cross-modal memory engram
Multisensory learning binds modality-specific neurons into a cross-modal memory engram Open
Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory …
View article: Thirst increases astrocytic release and synthesis of D-serine to promote water procurement
Thirst increases astrocytic release and synthesis of D-serine to promote water procurement Open
Thirst increases astrocytic release and synthesis of D-serine to promote water procurement SCCMI uses single-cell sequencing to gain a whole-brain understanding of memory and motivational states. Study of thirst revealed the primary transc…
View article: Gliotransmission of D-serine promotes thirst-directed behaviors in<i>Drosophila</i>
Gliotransmission of D-serine promotes thirst-directed behaviors in<i>Drosophila</i> Open
Thirst emerges from a range of cellular changes that ultimately motivate an animal to consume water. Although thirst-responsive neuronal signals have been reported, the full complement of brain responses is unclear. Here we identify molecu…
View article: Different dopaminergic neurons signal absolute and relative aversive value in the <i>Drosophila</i> mushroom body
Different dopaminergic neurons signal absolute and relative aversive value in the <i>Drosophila</i> mushroom body Open
Animals use prior experience to assign absolute (good or bad) and also relative (better or worse) value to new experience. These learned values guide appropriate later decision-making. While our understanding of how the dopaminergic system…
View article: CMTr cap-adjacent 2’-<i>O</i>-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses
CMTr cap-adjacent 2’-<i>O</i>-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses Open
Cap-adjacent nucleotides of animal, protist and viral mRNAs can be dynamically O -methylated at the 2’ position of the ribose (cOMe). The functions of cOMe in animals, however, remain unknown. Here we show that the two cap methyltransferas…
View article: Prior experience conditionally inhibits the expression of new learning in Drosophila
Prior experience conditionally inhibits the expression of new learning in Drosophila Open
Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. H…
View article: Selective dendritic localization of mRNA in Drosophila mushroom body output neurons
Selective dendritic localization of mRNA in Drosophila mushroom body output neurons Open
Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments. Here, we used single-…
View article: An opposing self-reinforced odor pre-exposure memory produces latent inhibition in<i>Drosophila</i>
An opposing self-reinforced odor pre-exposure memory produces latent inhibition in<i>Drosophila</i> Open
Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. H…
View article: Data points figures of Selective dendritic localization of mRNA in Drosophila Mushroom Body Output Neurons
Data points figures of Selective dendritic localization of mRNA in Drosophila Mushroom Body Output Neurons Open
raw data points for the figures
View article: Selective dendritic localization of mRNA in Drosophila Mushroom Body Output Neurons
Selective dendritic localization of mRNA in Drosophila Mushroom Body Output Neurons Open
Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments. Here we used single-m…
View article: The connectome of the adult Drosophila mushroom body provides insights into function
The connectome of the adult Drosophila mushroom body provides insights into function Open
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach …
View article: Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory
Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory Open
Dietary magnesium (Mg 2+ ) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type …
View article: Author response: Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory
Author response: Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Dietary magnesium (Mg2+) supp…
View article: Transposon expression in the <i>Drosophila</i> brain is driven by neighboring genes and diversifies the neural transcriptome
Transposon expression in the <i>Drosophila</i> brain is driven by neighboring genes and diversifies the neural transcriptome Open
Somatic transposon expression in neural tissue is commonly considered as a measure of mobilization and has therefore been linked to neuropathology and organismal individuality. We combined genome sequencing data with single-cell mRNA seque…