Scott M. Williams
YOU?
Author Swipe
View article: Local genetic correlation analysis of Alzheimer’s disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry
Local genetic correlation analysis of Alzheimer’s disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry Open
Background Neuropathological studies indicate a strong association between Alzheimer’s disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear. Methods Local genetic correlation analysis was conduct…
View article: Geographic dimensions of gastric cancer risk in western Honduras: A spatial ecological analysis
Geographic dimensions of gastric cancer risk in western Honduras: A spatial ecological analysis Open
Gastric cancer is fifth most common cancer globally, with a complex and multifactorial etiology, including human and bacterial genetics, health behaviors, and environmental exposures. Honduras has among the highest rates of gastric cancer …
Alzheimer's disease plasma biomarkers in a global cohort: experience from the DAWN study Open
Background The DAWN study aims to investigate Alzheimer's disease (AD) genetics and underlying biological markers in a global population including African Americans (AA: 4,000) and Hispanic/Latinos (HI: 4,000) ascertained in the US and ind…
Characterizing the roles of race and ethnicity in late‐onset Alzheimer's disease Open
Background Race and ethnicity (R/E) are common descriptors used to stratify participants in genetic studies of late‐onset Alzheimer's disease (LOAD). These categories allow researchers to identify risk alleles, document effect size variati…
Dissecting Alzheimer Disease Heritability Across Multiple Populations Open
Background Late‐onset Alzheimer disease (LOAD) is highly heritable. Twin studies estimated up to 80% heritability in European populations. However, the range of narrow sense LOAD heritability estimates across multiple populations remains p…
View article: Genetic covariance analysis of Alzheimer's disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry
Genetic covariance analysis of Alzheimer's disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry Open
Background Neuropathological and neuroimaging studies indicate that cerebrovascular disease (CVD) is a major risk factor for Alzheimer's disease (AD), yet the molecular mechanisms underlying the association between the two traits remain un…
Evidence of recent natural selection at Alzheimer Disease risk loci and implications for precision medicine Open
Background Many of the over 70 single nucleotide polymorphisms (SNPs) that associate with late‐onset Alzheimer (LOAD) are common. LOAD risk alleles may achieve high frequency by providing beneficial effects earlier in life for other, as ye…
View article: Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage
Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage Open
Several studies examined host and pathogen genetic influences on tuberculosis (TB) susceptibility separately, but relatively few studied their combined effects. However, host-pathogen interactions or co-evolution may explain the inability …
View article: Disrupted Lipid Homeostasis as a Pathogenic Mechanism in <i>ABCA7</i> -Associated Alzheimer’s Disease Risk
Disrupted Lipid Homeostasis as a Pathogenic Mechanism in <i>ABCA7</i> -Associated Alzheimer’s Disease Risk Open
INTRODUCTION ABCA7 ( ATP-binding cassette sub-family A member 7 ) encodes a lipid transporter linked to Alzheimer’s disease (AD). While common variants confer modest risk in Europeans, a 44-base pair deletion (rs142076058; p.Arg578Alafs) i…
Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review Open
Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer’s disease (LOAD) and provides a rationale for identifying genetic factors associated with disease suscep…
Defining knowledge gaps in preterm birth research: Can biomarkers fill the gaps? Open
Preterm birth (PTB) is a syndrome arising from multiple etiologies that manifest as a final common phenotype, delivery before full term. Current knowledge gaps in epidemiologic, basic science, and clinical fields have limited our understan…
Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption Open
Background Clinical and genetic studies have implicated lipid dysfunction in Alzheimer Disease (AD) pathogenesis. While the etiologic impact of lipid intake on individuals is receiving attention, the role of food systems in shaping communi…
Institutional Characteristics Associated with Accessing and Sharing EHR Data with the National COVID Cohort Collaborative (N3C) Open
Purpose The National COVID Cohort Collaborative (N3C) is one of the largest centralized, individual-level clinical data repositories for COVID-19 research in the US. Some institutions do not share data with N3C. We sought to define factors…
Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review Open
Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer’s disease (LOAD), and provides a rationale for identifying genetic factors associated with disease susce…
Characterization of the gut microbiome in Alzheimer disease and mild cognitive impairment among older adults in Uganda: A case–control study Open
Alzheimer disease (AD) is associated with significant shifts in the gut microbiome and is characterized by reduced microbial diversity and changes in the abundance of specific taxa. These alterations can disrupt the gut-brain axis, leading…
Alzheimer disease incidence increases with country‐level intake of Omega‐6 Polyunsaturated Fatty Acids Open
Background Evidence from diverse fields implicates lipid dysfunction in Alzheimer Disease (AD) pathogenesis. However, lipid consumption at the individual level does not vary greatly within most study cohorts, and multiple lipids are rarely…
Evidence of recent evolutionary selection at eQTLs for APOE Open
Background Late‐onset Alzheimer Disease (LOAD) risk and prevalence differ by ancestral group. Furthermore, the frequency of APOE‐4 and its effect size on LOAD risk also differ by ancestry group. If these patterns are a function of evolutio…
Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption Open
INTRODUCTION Clinical and genetic studies have implicated lipid dysfunction in Alzheimer Disease (AD) pathogenesis. However, lipid consumption at the individual-level does not vary greatly within most cohorts, and multiple lipids are rarel…
Transcriptome- and DNA methylation-based cell-type deconvolutions produce similar estimates of differential gene expression and differential methylation Open
Background Changing cell-type proportions can confound studies of differential gene expression or DNA methylation (DNAm) from peripheral blood mononuclear cells (PBMCs). We examined how cell-type proportions derived from the transcriptome …
Application of Genomic Medicine in Africa: 14th Conference of the African Society of Human Genetics and the 2nd International Congress of the Moroccan Society of Genomics and Human Genetics, Rabat, Morocco 2022 Open
The 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 2…
Transcriptome- and DNA methylation-based cell-type deconvolutions produce similar estimates of differential gene expression and differential methylation Open
Background Changing cell-type proportions can confound studies of differential gene expression or DNA methylation (DNAm) from peripheral blood mononuclear cells (PBMCs). We examined how cell-type proportions derived from the transcriptome …
View article: A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma Open
Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, disproportionately affects individuals of African ancestry. We conducted a genome-wide association study (GWAS) for POAG in 11,275 individuals of Af…
Human genetics and genomics as a unifying factor for harmony and progress in Africa: a report from the 12<sup>th</sup> African Society of Human Genetics meeting in Bamako, Mali Open
Since its inception in 2003, the African Society of Human Genetics (AfSHG) has been central to the promotion of genetics research on the continent, and facilitated the networking of African researchers within Africa and abroad, thereby sig…