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View article: Analyses of vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens
Analyses of vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens Open
We have previously reported primary endpoints of a clinical trial testing two vaccine platforms for delivery of Plasmodium vivax malaria DBPRII: viral vectors (ChAd63, MVA) and protein/adjuvant (PvDBPII with 50µg Matrix-M™ adjuvant). Delay…
View article: Delayed booster dosing improves human antigen-specific Ig and B cell responses to the RH5.1/AS01<sub>B</sub> malaria vaccine
Delayed booster dosing improves human antigen-specific Ig and B cell responses to the RH5.1/AS01<sub>B</sub> malaria vaccine Open
Background Antibodies are crucial for vaccine-mediated protection against many pathogens. Modifications to vaccine delivery that increase antibody magnitude, longevity, and/or quality are therefore of great interest for maximising efficacy…