Sean B. Rourke
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View article: Advancing HIV pre-exposure prophylaxis (PrEP) implementation in Canada: a scoping review protocol of programmes, practices and policies
Advancing HIV pre-exposure prophylaxis (PrEP) implementation in Canada: a scoping review protocol of programmes, practices and policies Open
Introduction HIV pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool, reducing infection risk by up to 99% when used as prescribed. Despite its proven efficacy, PrEP uptake remains suboptimal, particularly among high-risk p…
View article: Study characteristics on health-related quality of life in older people living with human immunodeficiency virus: A narrative review
Study characteristics on health-related quality of life in older people living with human immunodeficiency virus: A narrative review Open
BACKGROUND People living with human immunodeficiency virus (HIV) are aging as a result the benefits of combination antiretroviral therapy. AIM To provide descriptions of eligible existing studies on demographics, methodologies, and outcome…
View article: Barriers and facilitators of HIV pre-exposure prophylaxis (PrEP) uptake and use in Canada: a scoping review protocol
Barriers and facilitators of HIV pre-exposure prophylaxis (PrEP) uptake and use in Canada: a scoping review protocol Open
Introduction Despite extensive efforts in HIV prevention, significant barriers to accessing interventions such as HIV pre-exposure prophylaxis (PrEP) persist in Canada. Although PrEP has demonstrated efficacy in preventing HIV transmission…
View article: Diagnosis of Learning Disabilities but not Academic Difficulties Alone is Associated with Neurocognitive Impairment in People Living with HIV: Evidence from Clinical Research to Support and Refine the Current HAND Diagnostic Guidelines
Diagnosis of Learning Disabilities but not Academic Difficulties Alone is Associated with Neurocognitive Impairment in People Living with HIV: Evidence from Clinical Research to Support and Refine the Current HAND Diagnostic Guidelines Open
View article: Racial disparities in HIV pre-exposure prophylaxis (PrEP) awareness and uptake among white, Black, and Indigenous men in Canada: Analysis of data from the I’m Ready national HIV self-testing study
Racial disparities in HIV pre-exposure prophylaxis (PrEP) awareness and uptake among white, Black, and Indigenous men in Canada: Analysis of data from the I’m Ready national HIV self-testing study Open
Objectives Black and Indigenous men in Canada continue to experience significant and disproportionate burden of new HIV infection. The purpose of this study was to understand racial differences in PrEP awareness and use, and PrEP cascade a…
View article: Development of a checklist for cognitive assessment requirements (CARE) based on a Delphi consensus study
Development of a checklist for cognitive assessment requirements (CARE) based on a Delphi consensus study Open
View article: A prospective multi-site study to evaluate the performance and usability of an oral fluid-based HIV self-test in Canada
A prospective multi-site study to evaluate the performance and usability of an oral fluid-based HIV self-test in Canada Open
View article: A Prospective Field Study to Evaluate the Performance and Acceptance of an Oral Fluid-Based HIV Self-Test in Canada
A Prospective Field Study to Evaluate the Performance and Acceptance of an Oral Fluid-Based HIV Self-Test in Canada Open
Background: Blood and oral fluid-based HIV self-tests are important for reaching the undiagnosed especially in key populations. The study objectives were to: (1) evaluate the oral fluid-based OraQuick® HIV Self-Test (HIV-ST) per…
View article: Disparate trajectories of cognitive aging among American Indian and Alaskan Native people with and without HIV.
Disparate trajectories of cognitive aging among American Indian and Alaskan Native people with and without HIV. Open
AI/AN disparities in trajectories of cognitive aging are evident and are likely explained by the interplay of biopsychosociocultural factors, including immunosenescence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
View article: The impact of HIV-related stigma on older and younger adults living with HIV disease: does age matter?
The impact of HIV-related stigma on older and younger adults living with HIV disease: does age matter? Open
The purpose of this study was to examine the independent influence of age on levels of HIV-related stigma experienced by adults living with HIV/AIDS. To accomplish this, cross-sectional data from the Ontario HIV Treatment Network Cohort St…
View article: Gender Differences in Severity and Correlates of Depression Symptoms in People Living with HIV in Ontario, Canada
Gender Differences in Severity and Correlates of Depression Symptoms in People Living with HIV in Ontario, Canada Open
This study investigates the differences in severity and correlates of depression symptoms among 1069 men and 267 women living with HIV in Ontario, Canada, who completed the 20-item Center for Epidemiologic Studies Depression Scale (CES-D).…
View article: Burden and risk factors for gastrointestinal symptom distress in HIV patients in the modern antiretroviral era
Burden and risk factors for gastrointestinal symptom distress in HIV patients in the modern antiretroviral era Open
In the modern antiretroviral (ARV) era, there is limited knowledge about the prevalence and risk factors for HIV patient-reported gastrointestinal (GI) symptoms (diarrhoea/soft stool, nausea/vomiting, bloating/painful abdomen, loss of appe…
View article: Validation of the Episodic Disability Framework with adults living with HIV
Validation of the Episodic Disability Framework with adults living with HIV Open
Purpose: To assess the validity of dimensions of disability in the Episodic Disability Framework, a conceptual framework derived from the perspective of adults living with HIV. Methods: We conducted confir…
View article: Protective and risk factors associated with stigma in a population of older adults living with HIV in Ontario, Canada
Protective and risk factors associated with stigma in a population of older adults living with HIV in Ontario, Canada Open
Although the deleterious effects of HIV stigma are well documented, less is known about how various types of stigma impact older adults living with HIV disease and what factors exacerbate or lessen the effects of HIV stigma. Using cross-se…
View article: Evidence Informing the Intersection of HIV, Aging and Health: A Scoping Review
Evidence Informing the Intersection of HIV, Aging and Health: A Scoping Review Open
The growing number of people over age 50 with HIV requires research, policy, and practice to develop a more comprehensive understanding of the health consequences of HIV in older individuals. We conducted a scoping review of peer-reviewed …
View article: Gastrointestinal Symptom Distress is Associated With Worse Mental and Physical Health-Related Quality of Life
Gastrointestinal Symptom Distress is Associated With Worse Mental and Physical Health-Related Quality of Life Open
Background: The prevalence of self-reported gastrointestinal (GI) symptoms and distress is high, but few studies have quantified their impact on health-related quality of life (HRQoL). Methods: We conducte…
View article: Gastrointestinal Symptom Distress is Associated With Worse Mental and Physical Health-Related Quality of Life
Gastrointestinal Symptom Distress is Associated With Worse Mental and Physical Health-Related Quality of Life Open
Background: The prevalence of self-reported gastrointestinal (GI) symptoms and distress is high, but few studies have quantified their impact on health-related quality of life (HRQoL). Methods: We conducte…
View article: Depressive symptoms, stress and resources among adult immigrants living with HIV
Depressive symptoms, stress and resources among adult immigrants living with HIV Open
Investigation on the mental health of HIV-positive immigrants is severely limited. We examine the independent and combined effects of HIV symptom and coping resources on depressive symptoms among HIV-positive immigrants (n = 259).…
View article: Examining the association between stress and antiretroviral therapy adherence among women living with HIV in Toronto, Ontario
Examining the association between stress and antiretroviral therapy adherence among women living with HIV in Toronto, Ontario Open
Background We aimed to identify the association between stress and antiretroviral therapy (ART) adherence among women in HIV care in Toronto, Ontario participating in the Ontario HIV Treatment Network Cohort Study (OCS) be…
View article: Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis
Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis Open
Background: We did a meta-analysis to assess factors associated with disparities in HIV infection in black men who have sex with men (MSM) in Canada, the UK, and the USA. Methods: We searched Embase, Medli…
View article: Relationships Between Dimensions of Disability Experienced by Adults Living with HIV: A Structural Equation Model Analysis
Relationships Between Dimensions of Disability Experienced by Adults Living with HIV: A Structural Equation Model Analysis Open
As individuals age with HIV it is increasingly important to consider the health-related consequences of HIV and multiple morbidities, known as disability. We assessed relationships between four dimensions of disability among adults living …
View article: Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis
Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: a meta-analysis Open
Background: We did a meta-analysis to assess factors associated with disparities in HIV infection in black men who have sex with men (MSM) in Canada, the UK, and the USA. Methods: We searched Embase, Medli…
View article: Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals
Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals Open
Purpose: Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on heal…
View article: Examining the association between stress and antiretroviral therapy adherence among women living with HIV in Toronto, Ontario
Examining the association between stress and antiretroviral therapy adherence among women living with HIV in Toronto, Ontario Open
Background We aimed to identify the association between stress and antiretroviral therapy (ART) adherence among women in HIV care in Toronto, Ontario participating in the Ontario HIV Treatment Network Cohort Study (OCS) be…
View article: Cognitive criteria in HIV: greater consensus is needed
Cognitive criteria in HIV: greater consensus is needed Open
A recently published Consensus Statement by Sam Nightingale and colleagues (Nightingale, S. et al. Cognitive impairment in people living with HIV: consensus recommendations for a new approach. Nat. Rev. Neurol. 19, 424–433; 2023)1 proposes…
View article: Mindfulness and cognitive training interventions that address intersecting cognitive and aging needs of older adults
Mindfulness and cognitive training interventions that address intersecting cognitive and aging needs of older adults Open
Summary Mindfulness and cognitive training interventions are promising models to address impacts (e.g., anxiety and stress) of cognitive impairment among older adults. Combining strategies may yield better outcomes than models offered in i…
View article: The impact of social determinants of health on the relationship between stigma and health in people living with HIV: A two-wave panel study
The impact of social determinants of health on the relationship between stigma and health in people living with HIV: A two-wave panel study Open
Background HIV stigma is still prevalent and negatively impacts the health of people living with HIV. Social determinants of health also have a significant impact on health, yet there is little work examining how these determinants play a …
View article: The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatment
The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatment Open
Depression and neurocognitive disorder continue to be the major neuropsychiatric disorders affecting persons with HIV (PWH). The prevalence of major depressive disorder is two to fourfold higher among PWH than the general population (∼6.7%…
View article: Sensitivity and specificity of two investigational Point of care tests for Syphilis and HIV (PoSH Study) for the diagnosis and treatment of infectious syphilis in Canada: a cross-sectional study
Sensitivity and specificity of two investigational Point of care tests for Syphilis and HIV (PoSH Study) for the diagnosis and treatment of infectious syphilis in Canada: a cross-sectional study Open
View article: Building capacity in quantitative research and data storytelling to enhance knowledge translation: a training curriculum for peer researchers
Building capacity in quantitative research and data storytelling to enhance knowledge translation: a training curriculum for peer researchers Open
Background Many community-based HIV research studies incorporate principles of greater involvement and meaningful engagement of people living with HIV (GIPA/MEPA) by training people with HIV as peer researchers. Unfortunately, there are st…