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View article: Comparison of Laboratory and Field Methods for Biosand Filter Sand Characterization
Comparison of Laboratory and Field Methods for Biosand Filter Sand Characterization Open
The Centre for Affordable Water and Sanitation Technology (CAWST) (2012) recommends size standards for the effective size (ES) and uniformity coefficient (UC) of filtration media in biosand filters (BSFs) to ensure optimal effluent flow ra…
View article: Effects of chronic volume deprivation on the ventricle
Effects of chronic volume deprivation on the ventricle Open
OBJECTIVES Little is known of the haemodynamic changes following chronic ventricular volume deprivation, which impact understanding the disease course and treatment results. An animal model was created to study the effects of chronic ventr…
View article: Correlation of cardiac risk factors with carotid and radial intima–media thickness measurements
Correlation of cardiac risk factors with carotid and radial intima–media thickness measurements Open
Male gender, increased age, hypertension, diabetes, hypercholesterolaemia and smoking significantly contributed to a thickened CIMT, whereas only hypercholesterolaemia was associated with a thickened RIMT. Hypertension had the most signifi…
View article: High frequency of SARS-CoV-2 infection in children admitted to academic hospitals in central South Africa
High frequency of SARS-CoV-2 infection in children admitted to academic hospitals in central South Africa Open
Background. During the COVID‐19 pandemic, the Omicron variant was highly infectious in children, and resulted in high hospital admission rates in this population compared with other SARS‐CoV‐2 variants. Objective. To investigate the preval…
View article: How cardiac output is controlled in a Fontan circulation: an update
How cardiac output is controlled in a Fontan circulation: an update Open
Summary After creating a Fontan circuit, control of the circulation is shifted upstream from the ventricle to the newly created Fontan portal system. The goal of this review was to illustrate that the customary laws of biventricular cardia…
View article: Viruses identified in endomyocardial biopsy samples in idiopathic dilated cardiomyopathy patients in central South Africa
Viruses identified in endomyocardial biopsy samples in idiopathic dilated cardiomyopathy patients in central South Africa Open
Background: Heart failure and cardiomyopathy are problematic in South Africa. Viruses are important causes of myocarditis and cardiomyopathy. This study aimed to determine the distribution of viruses in endomyocardial heart biopsy samples …
View article: A validation of machine learning models for the identification of critically ill children presenting to the paediatric emergency room of a tertiary hospital in South Africa: A proof of concept
A validation of machine learning models for the identification of critically ill children presenting to the paediatric emergency room of a tertiary hospital in South Africa: A proof of concept Open
Background. Machine learning (ML) refers to computational algorithms designed to learn from patterns in data to provide insights or predictions related to that data. Objective. Multiple studies report the development of predictive models f…
View article: Undernutrition in young children with congenital heart disease undergoing cardiac surgery in a low-income environment
Undernutrition in young children with congenital heart disease undergoing cardiac surgery in a low-income environment Open
Background Malnutrition (undernutrition) in children with congenital disease (CHD) is a notable concern, with preoperative and persistent growth failure post-cardiac surgery contributing to poorer outcomes. Poor growth in children with CHD…
View article: CTNI-54. A COMBINED ANALYSIS OF TWO RANDOMISED STUDIES EXPLORING THE IMPACT OF EXTENDED POST-RADIATION TEMOZOLOMIDE ON SURVIVAL OUTCOMES IN NEWLY DIAGNOSED GLIOBLASTOMA
CTNI-54. A COMBINED ANALYSIS OF TWO RANDOMISED STUDIES EXPLORING THE IMPACT OF EXTENDED POST-RADIATION TEMOZOLOMIDE ON SURVIVAL OUTCOMES IN NEWLY DIAGNOSED GLIOBLASTOMA Open
BACKGROUND The optimal duration of post-radiation temozolomide in newly diagnosed glioblastoma remains unclear, with no published phase III randomised trials. Stupp protocol uses 6 months, however, in routine care, it is often extended to …
View article: Fee Fi Fo Fail: fairy stories for future failures
Fee Fi Fo Fail: fairy stories for future failures Open
Once upon a time, failure was believed to be a very bad thing. It is now seen as a means of living happily ever after. For some fail-fans, it is a magic kingdom called Acadreamia, where missteps make marketers stronger. For others, it is a…
View article: Vocalisation rates of the North Atlantic right whale (Eubalaena glacialis)
Vocalisation rates of the North Atlantic right whale (Eubalaena glacialis) Open
Vocalisation rates were measured from North Atlantic right whales (Eubalaena glacialis) in spring 1999-2000 in the Great South Channel and off Cape Cod, USA, and in summer 1999-2000 in the Bay of Fundy, Canada. Vocalisations were classed a…
View article: Elicitation of domain knowledge for a machine learning model for paediatric critical illness in South Africa
Elicitation of domain knowledge for a machine learning model for paediatric critical illness in South Africa Open
Objectives Delays in identification, resuscitation and referral have been identified as a preventable cause of avoidable severity of illness and mortality in South African children. To address this problem, a machine learning model to pred…
View article: Time to change the reference ranges of children's physiological observations in emergency care? A prospective study
Time to change the reference ranges of children's physiological observations in emergency care? A prospective study Open
Aim High heart and respiratory rates are key indicators in many published guidelines to identify and treat serious bacterial infection and sepsis in children, but the credibility of evidence underpinning what is considered abnormal is ques…
View article: Telehealth in cancer care during the COVID-19 pandemic
Telehealth in cancer care during the COVID-19 pandemic Open
Introduction The Victorian COVID-19 Cancer Network (VCCN) Telehealth Expert Working Group aimed to evaluate the telehealth (TH) experience for cancer patients, carers and clinicians with the rapid uptake of TH in early 2020 during the COVI…
View article: Development of artificial neural network models for paediatric critical illness in South Africa
Development of artificial neural network models for paediatric critical illness in South Africa Open
Objectives Failures in identification, resuscitation and appropriate referral have been identified as significant contributors to avoidable severity of illness and mortality in South African children. In this study, artificial neural netwo…
View article: The association between temperature, heart rate, and respiratory rate in children aged under 16 years attending urgent and emergency care settings
The association between temperature, heart rate, and respiratory rate in children aged under 16 years attending urgent and emergency care settings Open
Background and importance Body temperature is considered an independent determinant of respiratory rate and heart rate; however, there is limited scientific evidence regarding the association. This study aimed to assess the association bet…
View article: Pre-operative neurodevelopmental assessment in young children undergoing cardiac surgery in central South Africa: feasibility and clinical value
Pre-operative neurodevelopmental assessment in young children undergoing cardiac surgery in central South Africa: feasibility and clinical value Open
Pre-operative neurodevelopmental assessment may be of high importance in South Africa to identify children at developmental risk, facilitating early referral to rehabilitation therapies.
View article: Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism
Sunitinib-Induced Adrenal Crisis in a Patient with Pre-Existing Immunotherapy-Related Hypopituitarism Open
Sunitinib is a tyrosine kinase inhibitor that is frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As a multikinase inhibitor, numerous off-target side effects of this medication are widely recognized. More recent…
View article: ds01.xlsx
ds01.xlsx Open
A research group from Jilin Univeristy, MIT and BU carried out a long Co-propagating longitudinal acoustic wave (CPLAW) experiment to understand the influence of water vapor and temperature on the nonlinear elastic properties (NEP) of rock…
View article: Association between Handwashing Behavior and Infectious Diseases among Low-Income Community Children in Urban New Delhi, India: A Cross-Sectional Study
Association between Handwashing Behavior and Infectious Diseases among Low-Income Community Children in Urban New Delhi, India: A Cross-Sectional Study Open
Diarrheal diseases and respiratory infections (RI) are two leading causes of childhood mortality in low and middle-income countries. Effective handwashing at critical time-points may mitigate these diseases. However, there is a lack of pub…
View article: Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of <i>Clostridioides difficile</i> Infection
Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of <i>Clostridioides difficile</i> Infection Open
Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/mono…