Sean Byars
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View article: RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts
RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts Open
To our knowledge, this is the first large-scale gene expression study focusing on these secondary cataracts. This dataset will assist in forming a broader knowledge base of secondary cataract pathogenesis and inform future research in this…
View article: Antibody responses against bacterial glycans affinity mature and diversify in germinal centers
Antibody responses against bacterial glycans affinity mature and diversify in germinal centers Open
Summary Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. By studying responses to Streptococcus pyogenes in humans, we reveal that the glycan-targeted response shift…
View article: Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy
Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy Open
Our study reports on a novel Kcnq2 DEE mouse model recapitulating aspects of the disease phenotype with the electrophysiological and transcriptome analysis providing insights into KCNQ2 DEE mechanisms that can be leveraged for future thera…
View article: First description of ventilation strategy-specific phenotypes involved in initiating preterm lung injury
First description of ventilation strategy-specific phenotypes involved in initiating preterm lung injury Open
The associated publication reports proteomic analysis of preterm lung tissue, where we identified protein subtypes associated with different aeration strategies applied at birth in the preterm lung with acute RDS. This protocol describes t…
View article: Emerging neurodevelopmental mechanisms in patient induced pluripotent stem cells-derived spheroids modelling<i>SCN1A</i>Dravet Syndrome
Emerging neurodevelopmental mechanisms in patient induced pluripotent stem cells-derived spheroids modelling<i>SCN1A</i>Dravet Syndrome Open
SCN1A encodes Naᵥ1.1, a voltage-gated sodium channel preferentially expressed in GABAergic interneurons, and it is the major cause of Dravet Syndrome (DS), a rare condition of developmental and epileptic encephalopathy (DEE). Among over 10…
View article: Four-week inhibition of the renin–angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks
Four-week inhibition of the renin–angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks Open
Aims Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin–angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously …
View article: Distinctive<i>in vitro</i>phenotypes in iPSC-derived neurons from patients with gain- and loss-of-function<i>SCN2A</i>developmental and epileptic encephalopathy
Distinctive<i>in vitro</i>phenotypes in iPSC-derived neurons from patients with gain- and loss-of-function<i>SCN2A</i>developmental and epileptic encephalopathy Open
SCN2A encodes Na V 1.2, an excitatory neuron voltage-gated sodium channel and a major monogenic cause of neurodevelopmental disorders, including developmental and epileptic encephalopathies (DEE) and autism. Clinical presentation and pharm…
View article: Vaccine Take of RV3-BB Rotavirus Vaccine Observed in Indonesian Infants Regardless of HBGA Status
Vaccine Take of RV3-BB Rotavirus Vaccine Observed in Indonesian Infants Regardless of HBGA Status Open
Background Histo-blood group antigen (HBGA) status may affect vaccine efficacy due to rotavirus strains binding to HBGAs in a P genotype–dependent manner. This study aimed to determine if HBGA status affected vaccine take of the G3P[6] neo…
View article: Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressure
Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressure Open
BACKGROUND Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontane…
View article: Distinctive<i>in vitro</i>phenotypes in iPSC-derived neurons from patients with gain- and loss-of-function<i>SCN2A</i>developmental and epileptic encephalopathy
Distinctive<i>in vitro</i>phenotypes in iPSC-derived neurons from patients with gain- and loss-of-function<i>SCN2A</i>developmental and epileptic encephalopathy Open
SCN2A encodes Na V 1.2, an excitatory neuron voltage-gated sodium channel and major monogenic cause of neurodevelopmental disorders, including developmental and epileptic encephalopathies (DEE) and autism. Clinical presentation and pharmoc…
View article: Respiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung
Respiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung Open
Bronchopulmonary disease is the chronic manifestation of the acute injury that may accompany ventilation following preterm birth. A lack of clear trial evidence often hampers clinical decision-making during support of the preterm lung at b…
View article: Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney Open
Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 (COVID-19). However, the effect of renin-angiotensin system (RAS)-…
View article: Breadwinners and Losers: Does the Mental Health of Mothers, Fathers, and Children Vary by Household Employment Arrangements? Evidence From 7 Waves of Data From the Longitudinal Study of Australian Children
Breadwinners and Losers: Does the Mental Health of Mothers, Fathers, and Children Vary by Household Employment Arrangements? Evidence From 7 Waves of Data From the Longitudinal Study of Australian Children Open
In Australia, as in many industrialized countries, the past 50 years have been marked by increasing female labor-force participation. It is popularly speculated that this might impose a mental-health burden on women and their children. Thi…
View article: Hypertension and renin-angiotensin system blockers are not associated with expression of Angiotensin Converting Enzyme 2 (ACE2) in the kidney
Hypertension and renin-angiotensin system blockers are not associated with expression of Angiotensin Converting Enzyme 2 (ACE2) in the kidney Open
Angiotensin converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2) - the cause of COVID-19 disease. It has been hypothesized that use of renin-angiotensin system (RAS) inhibiti…
View article: ‘I’m proud of how far I’ve come. I’m just ready to work’: mental health recovery narratives within the context of Australia’s Disability Employment Services
‘I’m proud of how far I’ve come. I’m just ready to work’: mental health recovery narratives within the context of Australia’s Disability Employment Services Open
Background Employment is recognised as facilitating the personal and clinical recovery of people with psychosocial disability. Yet this group continue to experience considerable barriers to work, and, constitute a significant proportion of…
View article: THE AUSTRALIAN DISABILITY AND VIOLENCE DATA COMPENDIUM
THE AUSTRALIAN DISABILITY AND VIOLENCE DATA COMPENDIUM Open
The Royal Commission into Violence, Abuse, Neglect and Exploitation of People with Disability was established in April 2019 in response to years of calls for action and mounting evidence that people with disability experience high and sust…
View article: Do gender and psychosocial job stressors modify the relationship between disability and sickness absence: An investigation using 12 waves of a longitudinal cohort
Do gender and psychosocial job stressors modify the relationship between disability and sickness absence: An investigation using 12 waves of a longitudinal cohort Open
Objectives A considerable proportion of the working population reports a disability. These workers may be at risk of adverse outcomes, including longer periods of sickness absence. This study examined the causal effect of disability on sic…
View article: P29 Is workforce participation detrimental to the mental health of women andchildren? Evidence from six waves of data from the longitudinal study of australian children
P29 Is workforce participation detrimental to the mental health of women andchildren? Evidence from six waves of data from the longitudinal study of australian children Open
Background The past 50 years has been marked by the increasing participation of women in the workforce. There is some evidence that this expansion of women into the workforce may impose a mental health burden on women, and it is popularly …
View article: Human Neonatal Rotavirus Vaccine (RV3-BB) Produces Vaccine Take Irrespective of Histo-Blood Group Antigen Status
Human Neonatal Rotavirus Vaccine (RV3-BB) Produces Vaccine Take Irrespective of Histo-Blood Group Antigen Status Open
Background VP4 [P] genotype binding specificities of rotaviruses and differential expression of histo-blood group antigens (HBGAs) between populations may contribute to reduced efficacy against severe rotavirus disease. P[6]-based rotaviru…
View article: Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury
Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury Open
Objectives: To characterize time-dependent and regionally-specific injury patterns associated with early ventilation of the preterm lung using a mass-spectrometry based proteomic approach. Methods: Preterm lambs delivered at gestational ag…
View article: Misspelled Surname in Byline and Author Contributions
Misspelled Surname in Byline and Author Contributions Open
Maisie Shindo, MD; James Lim, MD; Enrique Leon; Lauren Moneta, MD; Ryan Li, MD; Lourdes Quintanilla-Dieck, MD
View article: Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Removal of Adenoids and Tonsils in Childhood
Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Removal of Adenoids and Tonsils in Childhood Open
In this study of almost 1.2 million children, of whom 17 460 had adenoidectomy, 11 830 tonsillectomy, and 31 377 adenotonsillectomy, surgeries were associated with increased long-term risks of respiratory, infectious, and allergic diseases…
View article: Increased risk of many early-life diseases after surgical removal of adenoids and tonsils in childhood
Increased risk of many early-life diseases after surgical removal of adenoids and tonsils in childhood Open
BACKGROUND Surgical removal of the adenoids and tonsils are common pediatric procedures, with conventional wisdom suggesting their absence has little impact on health or disease. However, little is known about long-term health consequences…
View article: Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy
Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy Open
Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their …