Sean P. Curran
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View article: Form and function of actin impacts actin health and aging
Form and function of actin impacts actin health and aging Open
The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and phar…
View article: Parental age selection in <i>C. elegans</i> influences progeny stress resistance capacity
Parental age selection in <i>C. elegans</i> influences progeny stress resistance capacity Open
With parental age rising around the globe, an increased understanding of the impact on health and longevity is needed. Here, we report how the continuous selection of the last progeny during the Caenorhabditis elegans reproductive span res…
View article: Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals
Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals Open
The National Institute on Aging-funded Geroscience Education and Training Network held the “Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals” preconference workshop at the 2023 Gerontologi…
View article: Parental age selection in <i>C. elegans</i> influences progeny stress resistance capacity
Parental age selection in <i>C. elegans</i> influences progeny stress resistance capacity Open
With parental age rising around the globe, an increased understanding of the impact on health and longevity is needed. Here, we report how the continuous selection of the last progeny during the Caenorhabditis elegans reproductive span res…
View article: WormRACER: Robust Analysis by Computer-Enhanced Recording
WormRACER: Robust Analysis by Computer-Enhanced Recording Open
View article: DEFINING A NOVEL HOMEOSTAT THAT SENSES THE BARRIERS OF PARENTAL REPRODUCTIVE-SPAN AND SETS PROGENY STRESS CAPACITY
DEFINING A NOVEL HOMEOSTAT THAT SENSES THE BARRIERS OF PARENTAL REPRODUCTIVE-SPAN AND SETS PROGENY STRESS CAPACITY Open
The ability to respond to stressors quickly and adequately is a core component to survival, and dysregulation of these resistance pathways can be debilitating. The cytoprotective transcription factor SKN-1 plays a critical role in response…
View article: ACTIVATED SKN-1 ALTERS THE LONGEVITY TRAJECTORY OF LONG-LIVED C. ELEGANS MUTANTS
ACTIVATED SKN-1 ALTERS THE LONGEVITY TRAJECTORY OF LONG-LIVED C. ELEGANS MUTANTS Open
In the presence of stressful environments, the SKN-1 cytoprotective transcription factor is activated to induce the expression of gene targets that can restore homeostasis. However, constitutive activation of SKN-1 results in diminished he…
View article: SEROTONIN DEFICIENCY FROM CONSTITUTIVE SKN-1 ACTIVATION DRIVES PATHOGEN APATHY
SEROTONIN DEFICIENCY FROM CONSTITUTIVE SKN-1 ACTIVATION DRIVES PATHOGEN APATHY Open
When an organism encounters a pathogen, the host innate immune system activates to defend against pathogen colonization and toxic xenobiotics produced. In humans, nuclear factor erythroid 2-related factor (Nrf2) is a critical regulator in …
View article: SKN-1 ISOFORM-C IS ESSENTIAL FOR C. ELEGANS DEVELOPMENT
SKN-1 ISOFORM-C IS ESSENTIAL FOR C. ELEGANS DEVELOPMENT Open
The transcription factor SKN-1 in Caenorhabditis elegans is a critical regulator of various biological processes, impacting development, diet and immune responses, cellular detoxification, and lipid metabolism; thereby playing a pivotal ro…
View article: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy Open
View article: Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutants
Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutants Open
In the presence of stressful environments, the SKN-1 cytoprotective transcription factor is activated to induce the expression of gene targets that can restore homeostasis. However, chronic activation of SKN-1 results in diminished health …
View article: Distinct mechanisms of non-autonomous UPR<sup>ER</sup>mediated by GABAergic, glutamatergic, and octopaminergic neurons
Distinct mechanisms of non-autonomous UPR<sup>ER</sup>mediated by GABAergic, glutamatergic, and octopaminergic neurons Open
The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR ER ) is one such conserved mech…
View article: Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity
Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity Open
View article: SKN-1 isoform-c is essential for C. elegans development
SKN-1 isoform-c is essential for C. elegans development Open
The transcription factor SKN-1 in Caenorhabditis elegans is a critical regulator of various biological processes, impacting development, diet and immune responses, cellular detoxification, and lipid metabolism; thereby playing a piv…
View article: Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes
Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes Open
The mechanisms that govern maintenance of cellular homeostasis are crucial to the lifespan and healthspan of all living systems. As an organism ages, there is a gradual decline in cellular homeostasis that leads to senescence and death. As…
View article: Oolonghomobisflavans from<i>Camellia sinensis</i>disaggregate tau fibrils across Alzheimer’s disease models
Oolonghomobisflavans from<i>Camellia sinensis</i>disaggregate tau fibrils across Alzheimer’s disease models Open
Alzheimer’s disease (AD) is a common debilitating neurodegenerative disease with limited treatment options. Amyloid-β (Aβ) and tau fibrils are well-established hallmarks of AD, which can induce oxidative stress, neuronal cell death, and ar…
View article: <i>C. elegans</i>display antipathy behavior towards food after contemporaneous integration of nutritional needs and dietary lipid availability
<i>C. elegans</i>display antipathy behavior towards food after contemporaneous integration of nutritional needs and dietary lipid availability Open
SUMMARY Organisms utilize sophisticated neurocircuitry to select optimal food sources within their environment. Methylobacterium is a lifespan-promoting bacterial diet for C. elegans that drives faster development and longevity, however af…
View article: Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy
Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy Open
When an organism encounters a pathogen, the host innate immune system activates to defend against pathogen colonization and toxic xenobiotics produced. C. elegans employ multiple defense systems to ensure survival when exposed to Pseudomon…
View article: WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus Open
View article: Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain
Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain Open
View article: Closing the gap: improving the percentage of Annual Wellness Visits among Medicare patients
Closing the gap: improving the percentage of Annual Wellness Visits among Medicare patients Open
Background The Medicare Annual Wellness Visit (AWV) allows providers to acquire critical information about patients’ health through a review of vitals, environmental risks, and medical and family history. These visits are free to those enr…
View article: A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons
A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons Open
Coordination of cellular responses to stress is essential for health across the lifespan. The transcription factor SKN-1 is an essential homeostat that mediates survival in stress-inducing environments and cellular dysfunction, but constit…
View article: PATHOGEN APATHY RESULTING FROM SKN-1 ACTIVATION: A MARK OF RESILIENCE OR A RATTLED GUT FEELING?
PATHOGEN APATHY RESULTING FROM SKN-1 ACTIVATION: A MARK OF RESILIENCE OR A RATTLED GUT FEELING? Open
Innate immunity is a key driver in promoting survival against xenobiotic stressors and hostile environments and an appropriate immune response is essential to organismal health across lifespan. Caenorhabditis elegans encounter pathogens in…
View article: WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus Open
Pathogenic brain aging and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are characterized by chronic neuroinflammation and the accumulation of dysfunctional or misfolded proteins that lead to progressive n…
View article: A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons
A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons Open
Coordination of cellular responses to stress are essential for health across the lifespan. The transcription factor SKN-1 is an essential homeostat that mediates survival in stress-inducing environments and cellular dysfunction, but consti…
View article: Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation
Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation Open
Molecular homeostats play essential roles across all levels of biological organization to ensure a return to normal function after responding to abnormal internal and environmental events. SKN-1 is an evolutionarily conserved cytoprotectiv…
View article: Loss of Wdr23 drives neuronal mitochondrial biogenesis
Loss of Wdr23 drives neuronal mitochondrial biogenesis Open
Mitochondrial adaptation is important for stress resistance throughout life. Here we show that WDR23 loss results in an enrichment for genes regulated by nuclear respiratory factor 1 (NRF1), which coordinates mitochondrial biogenesis and r…
View article: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans
Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans Open
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favora…
View article: Different methods of killing bacteria diets differentially influence Caenorhabditis elegans physiology
Different methods of killing bacteria diets differentially influence Caenorhabditis elegans physiology Open
Across species, diet plays a critical role in most, if not all life history traits. Caenorhabditis elegans is an important and facile organism for research across modalities, but the use of live bacteria as sources of nutrition can …
View article: Author response: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans
Author response: Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans Open
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