Sean Davin
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View article: Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis
Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis Open
Ankylosing spondylitis (AS), also known as radiographic axial spondyloarthritis (r-axSpA), is an immune-mediated inflammatory disorder frequently associated with acute anterior uveitis (AAU). Both conditions share a strong association with…
View article: Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) of peripheral blood to dissect the effect of different spondyloarthropathies
Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) of peripheral blood to dissect the effect of different spondyloarthropathies Open
Spondyloarthritis is a family of immune mediated inflammatory disorders with overlapping articular and extraarticular clinical manifestations and a strong association to human leukocyte antigen (HLA)-B27. Despite a strong association of HL…
View article: Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota Open
Axial spondyloarthritis (axSpA) is an inflammatory arthritis involving the spine and the sacroiliac joint with extra-articular manifestations in the eye, gut, and skin. The intestinal microbiota has been implicated as a central environment…
View article: Network-Based Differences in the Vaginal and Bladder Microbial Communities Between Women With and Without Urgency Urinary Incontinence
Network-Based Differences in the Vaginal and Bladder Microbial Communities Between Women With and Without Urgency Urinary Incontinence Open
Background Little is known about the relationship of proximal urogenital microbiomes in the bladder and the vagina and how this contributes to bladder health. In this study, we use a microbial ecology and network framework to understand th…
View article: Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota Open
Objective To investigate whether axial spondyloarthritis (AxSpA) patients have an altered immunoglobulin A (IgA) response in the gut and oral microbial communities. Methods We performed 16S rRNA gene (16S) sequencing on IgA positive (IgA +…
View article: The impact of genetic background and sex on the phenotype of IL-23 induced murine spondyloarthritis
The impact of genetic background and sex on the phenotype of IL-23 induced murine spondyloarthritis Open
Background Overexpression of IL-23 in adult mice by means of hydrodynamic tail vein injection of IL-23 minicircles has been reported to result in spondyloarthritis-like disease. The impact of genetic background and sex on the disease pheno…
View article: The impact of genetic background and sex on the phenotype of IL-23 induced murine arthritis
The impact of genetic background and sex on the phenotype of IL-23 induced murine arthritis Open
Background Overexpression of IL-23 in adult mice by means of hydrodynamic tail vein injection of IL-23 minicircles has been reported to result in spondyloarthritis-like disease. The impact of genetic background and sex on the disease pheno…
View article: Controlling for Contaminants in Low-Biomass 16S rRNA Gene Sequencing Experiments
Controlling for Contaminants in Low-Biomass 16S rRNA Gene Sequencing Experiments Open
The relative scarcity of microbes in low-microbial-biomass environments makes accurate determination of community composition challenging. Identifying and controlling for contaminant bacterial DNA are critical steps in understanding microb…
View article: Controlling for contaminants in low biomass 16S rRNA gene sequencing experiments
Controlling for contaminants in low biomass 16S rRNA gene sequencing experiments Open
Background Microbial communities are commonly studied using culture-independent methods such as 16S rRNA gene sequencing. However, one challenge in accurately characterizing microbial communities is exogenous bacterial DNA contamination. T…
View article: Intestinal Metabolites Are Profoundly Altered in the Context of HLA–B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis
Intestinal Metabolites Are Profoundly Altered in the Context of HLA–B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis Open
Objective HLA–B27–associated spondyloarthritides are associated with an altered intestinal microbiota and bowel inflammation. We undertook this study to identify HLA–B27–dependent changes in both host and microbial metabolites in the HLA–B…
View article: Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity?
Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity? Open
Our study provides further characterization of the urinary microbiome in both healthy controls and extensively phenotyped women with UUI. Our results also suggest that the urinary microbiome may play an important role in the pathophysiolog…
View article: Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis
Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis Open
Objective The HLA–B27/β 2 ‐microglobulin (β 2 m)–transgenic (Tg) rat is a leading model of B27‐associated spondyloarthritis (SpA), and the disease is dependent on the presence of intestinal bacteria. Previous studies have shown that adult …