Sean Foxley
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View article: Efficacy Assessment of Cerebral Perfusion Augmentation through Functional Connectivity in an Acute Canine Stroke Model
Efficacy Assessment of Cerebral Perfusion Augmentation through Functional Connectivity in an Acute Canine Stroke Model Open
NEH demonstrates potential as a proof-of-concept therapy for maintaining RSN functional connectivity after ischemic stroke, emphasizing the therapeutic promise of perfusion augmentation. These insights reinforce the role of functional conn…
View article: High-resolution diffusion imaging in the unfixed post-mortem infant brain at 7 T
High-resolution diffusion imaging in the unfixed post-mortem infant brain at 7 T Open
Diffusion MRI of the infant brain allows investigation of the organizational structure of maturing fibers during brain development. Post-mortem imaging has the potential to achieve high resolution by using long scan times, enabling precise…
View article: Tensor image registration library: Deformable registration of stand‐alone histology images to whole‐brain post‐mortem MRI data
Tensor image registration library: Deformable registration of stand‐alone histology images to whole‐brain post‐mortem MRI data Open
View article: An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons
An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons Open
View article: Tensor Image Registration Library: Automated Deformable Registration of Stand-Alone Histology Images to Whole-Brain Post-Mortem MRI Data
Tensor Image Registration Library: Automated Deformable Registration of Stand-Alone Histology Images to Whole-Brain Post-Mortem MRI Data Open
Background Accurate registration between microscopy and MRI data is necessary for validating imaging biomarkers against neuropathology, and to disentangle complex signal dependencies in microstructural MRI. Existing registration methods of…
View article: Application of a novel <scp>T1</scp> retrospective quantification using internal references (<scp>T1‐REQUIRE</scp>) algorithm to derive quantitative <scp>T1</scp> relaxation maps of the brain
Application of a novel <span>T1</span> retrospective quantification using internal references (<span>T1‐REQUIRE</span>) algorithm to derive quantitative <span>T1</span> relaxation maps of the brain Open
Most MRI sequences used clinically are qualitative or weighted. While such images provide useful information for clinicians to diagnose and monitor disease progression, they lack the ability to quantify tissue damage for more objective ass…
View article: Social connections predict brain structure in a multidimensional free-ranging primate society
Social connections predict brain structure in a multidimensional free-ranging primate society Open
Reproduction and survival in most primate species reflects management of both competitive and cooperative relationships. Here, we investigated the links between neuroanatomy and sociality in free-ranging rhesus macaques. In adults, the num…
View article: Model-free analysis in the spectral domain of postmortem mouse brain EPSI reveals inconsistencies with model-based analyses of the free induction decay
Model-free analysis in the spectral domain of postmortem mouse brain EPSI reveals inconsistencies with model-based analyses of the free induction decay Open
Purpose Dysmyelinating disorders lead to abnormalities in myelin structure that produce detectable effects in an echo-planar spectroscopic imaging (EPSI) signal. To estimate the voxel-wise proportion of myelin, data are typically fit to co…
View article: An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons
An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons Open
The acquisition of MRI and histology in the same post-mortem tissue sample enables direct correlation between MRI and histologically-derived parameters. However, there still lacks a standardised automated pipeline to process histology data…
View article: Author response: The Digital Brain Bank, an open access platform for post-mortem imaging datasets
Author response: The Digital Brain Bank, an open access platform for post-mortem imaging datasets Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Appendix 3 Appendix 4 Data availability References Decision letter Author response Article and author informa…
View article: The Digital Brain Bank, an open access platform for post-mortem imaging datasets
The Digital Brain Bank, an open access platform for post-mortem imaging datasets Open
Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain…
View article: A method to remove the influence of fixative concentration on postmortem <scp> T <sub>2</sub> </scp> maps using a kinetic tensor model
A method to remove the influence of fixative concentration on postmortem <span> T <sub>2</sub> </span> maps using a kinetic tensor model Open
Formalin fixation has been shown to substantially reduce T 2 estimates, primarily driven by the presence of fixative in tissue. Prior to scanning, post‐mortem samples are often placed into a fluid that has more favourable imaging propertie…
View article: The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections
The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections Open
View article: The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain
The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain Open
Diffusion MRI of the neonatal brain allows investigation of the organisational structure of maturing fibres during brain development. Post-mortem imaging has the potential to achieve high resolution by using long scan times, enabling preci…
View article: The Digital Brain Bank, an open access platform for post-mortem datasets
The Digital Brain Bank, an open access platform for post-mortem datasets Open
Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank ( open.win.ox.ac.uk/Di…
View article: Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution
Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution Open
View article: Synchrotron X‐ray micro‐CT as a validation dataset for diffusion MRI in whole mouse brain
Synchrotron X‐ray micro‐CT as a validation dataset for diffusion MRI in whole mouse brain Open
Purpose To introduce synchrotron X‐ray microcomputed tomography (microCT) and demonstrate its use as a natively isotropic, nondestructive, 3D validation modality for diffusion MRI in whole, fixed mouse brain. Methods Postmortem diffusion M…
View article: Structural Imaging-Based Biomarkers for Detecting Craving and Predicting Relapse in Subjects With Methamphetamine Dependence
Structural Imaging-Based Biomarkers for Detecting Craving and Predicting Relapse in Subjects With Methamphetamine Dependence Open
Background: Craving is the predictor of relapse, and insula cortex (IC) is a critical neural substrate for craving and drug seeking. This study investigated whether IC abnormalities among MA users can detect craving state and predict relap…
View article: Acute effects of alcohol on resting-state functional connectivity in healthy young men
Acute effects of alcohol on resting-state functional connectivity in healthy young men Open
View article: Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution
Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution Open
Mammalian neurons operate at length scales spanning five orders of magnitude; micron-scale-diameter myelinated axons project millimeters across brain regions, ultimately forming nanometer scale synapses on individual post-synaptic neurons.…
View article: A method to remove the influence of fixative concentration on post-mortem T<sub>2</sub>maps using a Kinetic Tensor model
A method to remove the influence of fixative concentration on post-mortem T<sub>2</sub>maps using a Kinetic Tensor model Open
Formalin fixation has been shown to substantially reduce T 2 estimates when performing post-mortem imaging, primarily driven by the presence of bulk fixative in tissue. Prior to scanning, post-mortem tissue samples are often placed into a …
View article: Longitudinal connections and the organization of the temporal cortex in macaques, great apes, and humans
Longitudinal connections and the organization of the temporal cortex in macaques, great apes, and humans Open
The temporal association cortex is considered a primate specialization and is involved in complex behaviors, with some, such as language, particularly characteristic of humans. The emergence of these behaviors has been linked to major diff…
View article: Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis
Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis Open
View article: Post-mortem QSM and R2* maps
Post-mortem QSM and R2* maps Open
This repository contains data associated with the following publication: Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis Authors: Chaoyue Wang, Sean Foxley,…
View article: Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP
Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP Open
Diffusion-weighted steady-state free precession (DW-SSFP) is an SNR-efficient diffusion imaging method. The improved SNR and resolution available at ultra-high field has motivated its use at 7T. However, these data tend to have severe B
View article: Post-mortem QSM and R2* maps
Post-mortem QSM and R2* maps Open
This repository contains data associated with the following publication: Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis Authors: Chaoyue Wang, Sean Foxley,…
View article: Gorilla and Chimpanzee Brains
Gorilla and Chimpanzee Brains Open
This repository contains data associated with the following publication: Longitudinal connections and the organization of the temporal cortex in macaques, great apes, and humans Authors: Roumazeilles L, Eichert N, Bryant KL, Folloni D, Sal…
View article: Gorilla and Chimpanzee Brains
Gorilla and Chimpanzee Brains Open
This repository contains data associated with the following publication: Longitudinal connections and the organization of the temporal cortex in macaques, great apes, and humans Authors: Roumazeilles L, Eichert N, Bryant KL, Folloni D, Sal…
View article: Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T
Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T Open
Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixe…
View article: White matter structure and myelin-related gene expression alterations with experience in adult rats
White matter structure and myelin-related gene expression alterations with experience in adult rats Open