Sean A. Gray
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View article: Temporal modulation of gene expression in a controlled Schistosoma mansoni human infection model
Temporal modulation of gene expression in a controlled Schistosoma mansoni human infection model Open
Background Schistosomiasis is caused by parasitic blood flukes of the genus Schistosoma . Despite ongoing mass drug administration efforts, the disease remains a major public health burden in endemic regions. A better understanding of earl…
View article: Safety and immunogenicity of the Sm-p80 GLA-SE schistosomiasis vaccine
Safety and immunogenicity of the Sm-p80 GLA-SE schistosomiasis vaccine Open
Schistosomiasis is a neglected tropical disease with the greatest burden in sub-Saharan Africa. An efficacious and safe vaccine would have a major global public health impact. The investigational SchistoShield® (Sm-p80 [antigen] + GLA-SE […
View article: Adjuvanted Protein Vaccines Boost RNA-Based Vaccines for Broader and More Potent Immune Responses
Adjuvanted Protein Vaccines Boost RNA-Based Vaccines for Broader and More Potent Immune Responses Open
Background/Objectives: mRNA vaccines introduced during the COVID-19 pandemic were a significant step forward in the rapid development and deployment of vaccines in a global pandemic context. These vaccines showed good protective efficacy, …
View article: Potential biomarker and composite efficacy readout for human clinical trials of schistosomiasis vaccine in Africa
Potential biomarker and composite efficacy readout for human clinical trials of schistosomiasis vaccine in Africa Open
Schistosomiasis is a chronic disease that inflicts high morbidity and significant mortality with an estimated 90% of cases occurring in sub-Saharan Africa. Development of a vaccine against schistosomiasis is a major global health goal. The…
View article: A Next-Generation Human Lymphatic Filariasis Vaccine Candidate, rBmHAXT, for Clinical Development
A Next-Generation Human Lymphatic Filariasis Vaccine Candidate, rBmHAXT, for Clinical Development Open
This study was conducted to yield a robust and scalable manufacturing process for a candidate vaccine for human lymphatic filariasis (LF) - a tropical parasitic infection transmitted by mosquitoes. In previous studies, we demonstrated that…
View article: Characterizing TLR4 agonist EmT4™ as an anti-<i>Mycobacterium tuberculosis</i> vaccine adjuvant
Characterizing TLR4 agonist EmT4™ as an anti-<i>Mycobacterium tuberculosis</i> vaccine adjuvant Open
Tuberculosis (TB) is again the deadliest infectious disease globally, and more efficacious vaccines are needed to reduce this mortality. Successful subunit TB vaccines need antigens and adjuvants that are immunogenic, inexpensive, and acce…
View article: An assessment of a GMP schistosomiasis vaccine (SchistoShield®)
An assessment of a GMP schistosomiasis vaccine (SchistoShield®) Open
Introduction Schistosomiasis is a neglected tropical disease that puts over 200 million people at risk, and prevention options are sparse with no approved vaccine. Our vaccine candidate, SchistoShield ® , is based on an approximately 87 kD…
View article: Transanal minimally invasive surgery (TAMIS) for local excision of benign and malignant rectal neoplasia: a 7-year experience
Transanal minimally invasive surgery (TAMIS) for local excision of benign and malignant rectal neoplasia: a 7-year experience Open
Purpose Transanal minimally invasive surgery (TAMIS) is an advanced transanal platform that can be utilised to perform high-quality local excision (LE) of rectal neoplasia. This study describes clinical and midterm oncological outcomes fro…
View article: Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates
Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates Open
Onchocerciasis remains a debilitating neglected tropical disease. Due to the many challenges of current control methods, an effective vaccine against the causative agent Onchocerca volvulus is urgently needed. Mice and cynomolgus macaque n…
View article: Pre-clinical development of a vaccine for human lymphatic filariasis
Pre-clinical development of a vaccine for human lymphatic filariasis Open
This study was conducted to optimize a fusion protein vaccine for translational development as a vaccine against the human tropical parasitic infection, lymphatic filariasis (LF). The vaccine candidate, His-tagged r Bm HAXT was developed p…
View article: Process Development of Sj-p80: A Low-Cost Transmission-Blocking Veterinary Vaccine for Asiatic Schistosomiasis
Process Development of Sj-p80: A Low-Cost Transmission-Blocking Veterinary Vaccine for Asiatic Schistosomiasis Open
Asiatic schistosomiasis caused by Schistosoma japonicum is a neglected tropical disease resulting in significant morbidity to both humans and animals - particularly bovines - in endemic areas. Infection with this parasite leads to less hea…
View article: Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates: Antibodies From Vaccinated Baboons Confer Protection in vivo and in vitro From Schistosoma mansoni and Identification of Putative Correlative Markers of Protection
Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates: Antibodies From Vaccinated Baboons Confer Protection in vivo and in vitro From Schistosoma mansoni and Identification of Putative Correlative Markers of Protection Open
Recent advances in systems biology have shifted vaccine development from a largely trial-and-error approach to an approach that promote rational design through the search for immune signatures and predictive correlates of protection. These…
View article: Authors of Independence: Comparing Thomas Paine and Camilo Henríquez as Revolutionary Writers
Authors of Independence: Comparing Thomas Paine and Camilo Henríquez as Revolutionary Writers Open
An nineteenth-century Chilean writer, Fr. Camilo Henriquez was a fascinating figure—a Catholic priest whose religious beliefs more closely aligned with Deism, a prolific proponent of Chilean independence, and, for a short while, the presid…
View article: A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen
A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen Open
Members of the Flaviviridae family are the leading causes of mosquito-borne viral disease worldwide. While dengue virus is the most prevalent, the recent Zika virus outbreak in the Americas triggered a WHO public health emergency, and yell…
View article: Bootstrapping the Three-dimensional Ising Model
Bootstrapping the Three-dimensional Ising Model Open
This thesis begins with the fundamentals of conformal field theory in three dimensions. The general properties of the conformal bootstrap are then reviewed. The three-dimensional Ising model is presented from the perspective of the renorma…